iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	31.9	226	276

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C + +          ++ ++ l+C+Hvfh+ C+  w    +   k+++CP+C+
   Q: 226  CAVCGQQIfvdvneegiiEN-TYRLSCNHVFHEFCIRGW----CIVGKKQTCPYCK 276
           9***9988888887777655.777***************....889999******7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAVVEVEVG GGAVAEREID EVDMSDLSPE EQWRVEHARM HAKHRGHEAM HAEMVLILIA 60
TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH WWRFLVIWIF FSAVTAFVTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAACACAC CTAGAATTCC GGCACCCAGG AGGCTGAAGC AGGATGATTT GAGAGTTGGA 60
GGTCAACCTA GGATACACGG TTGAGTTAAA GGTCAGCCTG GGCTACAGGG CAAGACCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

rno:308871

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002350	Ailuropoda melanoleuca	97.73	9.00e-174	602.00
IUUC-Apl-003882	Anas platyrhynchos	86.82	1.00e-140	492.00
IUUC-Aca-004343	Anolis carolinensis	91.30	3.00e-23	99.00
IUUC-Aly-005550	Arabidopsis lyrata	37.10	2.00e-06	47.40
IUUC-Ame-010680	Astyanax mexicanus	83.73	1.00e-160	558.00
IUUC-Bta-013045	Bos taurus	98.64	2.00e-165	574.00
IUUC-Bci-013624	Botrytis cinerea	36.21	2.00e-07	51.20
IUUC-Cel-018296	Caenorhabditis elegans	51.27	1.00e-98	353.00
IUUC-Cja-019866	Callithrix jacchus	98.06	2.00e-174	604.00
IUUC-Cfa-021176	Canis familiaris	97.46	1.00e-174	605.00
IUUC-Cpo-022268	Cavia porcellus	97.41	4.00e-172	597.00
IUUC-Cre-022649	Chlamydomonas reinhardtii	41.31	2.00e-54	205.00
IUUC-Csa-023727	Chlorocebus sabaeus	98.71	6.00e-175	606.00
IUUC-Cho-025016	Choloepus hoffmanni	98.39	1.00e-175	608.00
IUUC-Cin-025281	Ciona intestinalis	64.24	7.00e-125	439.00
IUUC-Csv-026338	Ciona savignyi	63.64	7.00e-113	399.00
IUUC-Dre-027836	Danio rerio	82.41	3.00e-143	500.00
IUUC-Dno-029737	Dasypus novemcinctus	96.81	2.00e-172	598.00
IUUC-Dor-031070	Dipodomys ordii	91.15	5.00e-155	540.00
IUUC-Dme-031867	Drosophila melanogaster	59.67	1.00e-112	399.00
IUUC-Ete-032964	Echinops telfairi	88.75	9.00e-165	572.00
IUUC-Eca-034398	Equus caballus	98.38	2.00e-174	604.00
IUUC-Eeu-035318	Erinaceus europaeus	63.06	2.00e-115	409.00
IUUC-Fca-035807	Felis catus	98.38	3.00e-172	597.00
IUUC-Fal-036721	Ficedula albicollis	95.83	1.00e-158	551.00
IUUC-Gmo-039699	Gadus morhua	87.66	5.00e-149	520.00
IUUC-Gga-040840	Gallus gallus	96.25	2.00e-161	560.00
IUUC-Gac-042639	Gasterosteus aculeatus	82.53	4.00e-149	520.00
IUUC-Ggo-045576	Gorilla gorilla	98.69	2.00e-172	598.00
IUUC-Hsa-046468	Homo sapiens	98.38	1.00e-174	605.00
IUUC-Itr-048638	Ictidomys tridecemlineatus	98.37	6.00e-146	509.00
IUUC-Lch-050207	Latimeria chalumnae	82.14	2.00e-143	501.00
IUUC-Loc-052172	Lepisosteus oculatus	88.93	1.00e-159	555.00
IUUC-Laf-053879	Loxodonta africana	97.44	2.00e-175	607.00
IUUC-Mcc-055492	Macaca mulatta	98.71	6.00e-175	606.00
IUUC-Meu-055976	Macropus eugenii	82.03	3.00e-137	481.00
IUUC-Mga-059989	Meleagris gallopavo	94.55	2.00e-168	584.00
IUUC-Mmr-060894	Microcebus murinus	98.71	6.00e-175	606.00
IUUC-Mdo-061826	Monodelphis domestica	95.41	6.00e-166	576.00
IUUC-Mmu-063717	Mus musculus	100.00	3.00e-176	610.00
IUUC-Mac-064444	Musa acuminata	47.22	3.00e-05	43.50
IUUC-Mpu-066826	Mustela putorius furo	98.38	9.00e-175	605.00
IUUC-Mlu-068081	Myotis lucifugus	94.19	1.00e-173	602.00
IUUC-Nle-069734	Nomascus leucogenys	98.71	6.00e-175	606.00
IUUC-Opr-070379	Ochotona princeps	95.50	5.00e-168	583.00
IUUC-Ont-071855	Oreochromis niloticus	82.53	2.00e-149	521.00
IUUC-Ocu-074363	Oryctolagus cuniculus	98.71	4.00e-176	610.00
IUUC-Ola-086489	Oryzias latipes	81.02	1.00e-147	515.00
IUUC-Oga-088323	Otolemur garnettii	98.70	6.00e-172	596.00
IUUC-Oar-090243	Ovis aries	97.43	1.00e-174	605.00
IUUC-Ptr-091374	Pan troglodytes	98.38	1.00e-174	605.00
IUUC-Pan-092115	Papio anubis	98.71	6.00e-175	606.00
IUUC-Psi-093658	Pelodiscus sinensis	96.35	2.00e-154	538.00
IUUC-Pfo-097261	Poecilia formosa	81.63	5.00e-148	516.00
IUUC-Pab-098579	Pongo abelii	98.38	1.00e-174	605.00
IUUC-Pop-099603	Populus trichocarpa	33.85	3.00e-06	46.60
IUUC-Pca-100119	Procavia capensis	92.93	8.00e-160	555.00
IUUC-Pva-102111	Pteropus vampyrus	98.37	5.00e-172	596.00
IUUC-Sha-107005	Sarcophilus harrisii	95.18	3.00e-172	597.00
IUUC-Stu-112248	Solanum tuberosum	39.66	1.00e-06	47.80
IUUC-Sar-113163	Sorex araneus	98.38	9.00e-175	605.00
IUUC-Ssc-115633	Sus scrofa	94.65	2.00e-171	594.00
IUUC-Tgu-116869	Taeniopygia guttata	97.28	8.00e-164	568.00
IUUC-Tru-118217	Takifugu rubripes	80.95	3.00e-155	540.00
IUUC-Tsy-119308	Tarsius syrichta	98.71	3.00e-175	607.00
IUUC-Tni-119882	Tetraodon nigroviridis	82.58	4.00e-157	546.00
IUUC-Tbe-127912	Tupaia belangeri	71.14	6.00e-108	383.00
IUUC-Ttr-129087	Tursiops truncatus	98.69	3.00e-173	600.00
IUUC-Vpa-130785	Vicugna pacos	91.96	1.00e-161	561.00
IUUC-Xtr-132801	Xenopus tropicalis	91.13	1.00e-156	545.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence