iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000002310.3	ENSOCUT00000002309.3	ENSOCUP00000001990.2
ENSOCUG00000002310.3	ENSOCUT00000027469.2	ENSOCUP00000019336.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.10e-38	132.9	93	262
UBD/ZnF/ZnF_A20	2.40e-25	88.2	754	787

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+ q+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++         de++ + k+++++   
   Q: 93   VALKTNGDGNCLMHAACQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwDDEWDDLVKMASTDtpv 181
           789**********************************************9*******************9999***********99777 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+g       eeihif+L++iL+rpi+v+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  ARGglqyhslEEIHIFVLCNILRRPIVVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 262
           774699999**********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k++C++ +C+++Gn+++ngyC++C++++++++
   Q: 754  PPKQRCRApACDHFGNAKCNGYCNECFQFKQMYG 787
           9*******************************96 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF 60
REIIHRALID RNIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAACQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAGGGTAG AAAGGAAACT GCGCAGTCTG CAGCCCTCGC AGCCGAGCGC CAGGACTTTG 60
GAGTGCGCGG GGGCGGACCG GCGGGGGCGG CCGCCAGAAG ACATCACACA CACCCCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

ocu:100350259

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	89.63	0.00e+00	1461.00
IUUC-Apl-003501	Anas platyrhynchos	66.08	0.00e+00	1045.00
IUUC-Aca-004245	Anolis carolinensis	64.55	0.00e+00	1066.00
IUUC-Ame-011789	Astyanax mexicanus	46.80	0.00e+00	697.00
IUUC-Bta-012664	Bos taurus	85.71	0.00e+00	1380.00
IUUC-Cja-019895	Callithrix jacchus	90.14	0.00e+00	1461.00
IUUC-Cfa-020754	Canis familiaris	90.01	0.00e+00	1470.00
IUUC-Cpo-021780	Cavia porcellus	88.40	0.00e+00	1436.00
IUUC-Csa-023568	Chlorocebus sabaeus	91.02	0.00e+00	1488.00
IUUC-Cho-024300	Choloepus hoffmanni	88.92	0.00e+00	650.00
IUUC-Dre-028577	Danio rerio	48.56	0.00e+00	683.00
IUUC-Dno-029382	Dasypus novemcinctus	82.28	0.00e+00	1337.00
IUUC-Dor-030874	Dipodomys ordii	85.08	0.00e+00	1374.00
IUUC-Ete-032721	Echinops telfairi	92.34	0.00e+00	811.00
IUUC-Eca-033596	Equus caballus	86.09	0.00e+00	1400.00
IUUC-Eeu-035159	Erinaceus europaeus	85.67	0.00e+00	1095.00
IUUC-Fca-035847	Felis catus	90.14	0.00e+00	1463.00
IUUC-Fal-036681	Ficedula albicollis	65.38	0.00e+00	1051.00
IUUC-Gmo-038521	Gadus morhua	58.82	7.00e-146	511.00
IUUC-Gga-040975	Gallus gallus	64.65	0.00e+00	1065.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.53	2.00e-151	530.00
IUUC-Ggo-045258	Gorilla gorilla	90.39	0.00e+00	1478.00
IUUC-Hsa-046071	Homo sapiens	90.52	0.00e+00	1479.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	91.02	0.00e+00	1475.00
IUUC-Lch-050326	Latimeria chalumnae	58.82	0.00e+00	929.00
IUUC-Loc-051945	Lepisosteus oculatus	45.92	4.00e-174	604.00
IUUC-Laf-053722	Loxodonta africana	87.61	0.00e+00	1434.00
IUUC-Mcc-055503	Macaca mulatta	90.64	0.00e+00	1481.00
IUUC-Meu-056481	Macropus eugenii	73.68	0.00e+00	1154.00
IUUC-Mga-059690	Meleagris gallopavo	63.46	0.00e+00	995.00
IUUC-Mmr-061233	Microcebus murinus	89.16	0.00e+00	1441.00
IUUC-Mdo-062446	Monodelphis domestica	79.57	0.00e+00	1283.00
IUUC-Mmu-063436	Mus musculus	87.04	0.00e+00	1398.00
IUUC-Mpu-066808	Mustela putorius furo	89.25	0.00e+00	1456.00
IUUC-Mlu-067339	Myotis lucifugus	88.31	0.00e+00	1436.00
IUUC-Nle-069888	Nomascus leucogenys	90.52	0.00e+00	1481.00
IUUC-Opr-070303	Ochotona princeps	92.44	0.00e+00	1513.00
IUUC-Ont-072283	Oreochromis niloticus	58.94	7.00e-147	514.00
IUUC-Oan-072925	Ornithorhynchus anatinus	76.10	0.00e+00	1224.00
IUUC-Ola-087417	Oryzias latipes	59.66	2.00e-147	516.00
IUUC-Oga-088708	Otolemur garnettii	86.22	0.00e+00	1358.00
IUUC-Oar-089271	Ovis aries	85.64	0.00e+00	1395.00
IUUC-Ptr-091296	Pan troglodytes	90.52	0.00e+00	1477.00
IUUC-Pan-092474	Papio anubis	90.77	0.00e+00	1484.00
IUUC-Psi-093447	Pelodiscus sinensis	69.52	0.00e+00	1114.00
IUUC-Pfo-096511	Poecilia formosa	59.90	8.00e-149	521.00
IUUC-Pab-098700	Pongo abelii	90.64	0.00e+00	1480.00
IUUC-Pca-100246	Procavia capensis	75.47	0.00e+00	1191.00
IUUC-Pva-102606	Pteropus vampyrus	77.66	2.00e-178	619.00
IUUC-Rno-105818	Rattus norvegicus	87.50	0.00e+00	1424.00
IUUC-Sha-106559	Sarcophilus harrisii	77.94	0.00e+00	1260.00
IUUC-Sar-113454	Sorex araneus	93.29	0.00e+00	648.00
IUUC-Ssc-116064	Sus scrofa	87.23	0.00e+00	1411.00
IUUC-Tgu-117212	Taeniopygia guttata	64.68	0.00e+00	1045.00
IUUC-Tru-118230	Takifugu rubripes	59.42	4.00e-150	525.00
IUUC-Tsy-119066	Tarsius syrichta	86.85	0.00e+00	1420.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.92	0.00e+00	672.00
IUUC-Tbe-127601	Tupaia belangeri	96.65	0.00e+00	674.00
IUUC-Ttr-128930	Tursiops truncatus	86.98	0.00e+00	1405.00
IUUC-Vpa-130450	Vicugna pacos	94.51	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence