iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036253

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02099963

Gene Name

SOCS6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000009195.2	ENSFCAT00000009197.2	ENSFCAP00000008521.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.30e-17	62.1	479	526

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 479  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 526
           5788999********************888...***************997 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MKKISLKTFR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKE DEKGGKSRSK 60
SESLMGTLKR RLSAKQKQKG KGSAPSGSSA DEDTFSSSSA PLVFKDVRAQ RPIRSTSLRN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAAAA TTAGTCTTAA AACCTTCCGA AAATCTTTCA ACTTGAATAA AAGTAAAGAA 60
GAAACGGATT TCATGGTAGT GCAGCAACCG TCACTGGCCA GTGATTTCGG AAAAGATGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	96.26	0.00e+00	924.00
IUUC-Atr-002940	Amborella trichopoda	33.96	1.70e+00	26.90
IUUC-Apl-004035	Anas platyrhynchos	89.91	0.00e+00	862.00
IUUC-Aca-004782	Anolis carolinensis	86.57	0.00e+00	816.00
IUUC-Ame-011790	Astyanax mexicanus	70.34	4.00e-180	624.00
IUUC-Bta-012579	Bos taurus	95.65	5.00e-109	387.00
IUUC-Bol-015843	Brassica oleracea	28.77	2.60e-02	33.10
IUUC-Cel-018643	Caenorhabditis elegans	33.59	1.00e-11	62.80
IUUC-Cja-019528	Callithrix jacchus	94.21	0.00e+00	962.00
IUUC-Cfa-020678	Canis familiaris	95.70	0.00e+00	945.00
IUUC-Cpo-021947	Cavia porcellus	94.21	0.00e+00	965.00
IUUC-Csa-023935	Chlorocebus sabaeus	94.02	0.00e+00	931.00
IUUC-Cho-024477	Choloepus hoffmanni	90.28	0.00e+00	919.00
IUUC-Cin-025413	Ciona intestinalis	68.24	3.00e-66	245.00
IUUC-Csv-026247	Ciona savignyi	67.47	6.00e-65	241.00
IUUC-Dre-027636	Danio rerio	68.66	3.00e-178	617.00
IUUC-Dno-029048	Dasypus novemcinctus	93.08	0.00e+00	920.00
IUUC-Dor-030401	Dipodomys ordii	90.28	0.00e+00	888.00
IUUC-Ete-033116	Echinops telfairi	50.18	9.00e-60	223.00
IUUC-Eca-033825	Equus caballus	95.51	0.00e+00	913.00
IUUC-Fal-037614	Ficedula albicollis	90.09	0.00e+00	864.00
IUUC-Fox-037898	Fusarium oxysporum	28.33	2.90e-01	28.90
IUUC-Gmo-038928	Gadus morhua	68.08	0.00e+00	641.00
IUUC-Gga-040177	Gallus gallus	89.35	0.00e+00	855.00
IUUC-Gac-042263	Gasterosteus aculeatus	70.11	0.00e+00	674.00
IUUC-Ggo-045288	Gorilla gorilla	93.64	0.00e+00	932.00
IUUC-Hsa-046409	Homo sapiens	94.02	0.00e+00	934.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	93.27	0.00e+00	901.00
IUUC-Lch-050354	Latimeria chalumnae	84.14	0.00e+00	842.00
IUUC-Loc-052319	Lepisosteus oculatus	81.53	0.00e+00	790.00
IUUC-Laf-054070	Loxodonta africana	90.65	0.00e+00	870.00
IUUC-Mcc-055045	Macaca mulatta	93.64	0.00e+00	927.00
IUUC-Meu-055917	Macropus eugenii	89.72	0.00e+00	924.00
IUUC-Mga-059273	Meleagris gallopavo	89.53	0.00e+00	856.00
IUUC-Mmr-061597	Microcebus murinus	94.77	0.00e+00	940.00
IUUC-Mdo-062492	Monodelphis domestica	66.17	3.00e-105	374.00
IUUC-Mmu-063374	Mus musculus	82.16	0.00e+00	805.00
IUUC-Mpu-065967	Mustela putorius furo	91.78	0.00e+00	887.00
IUUC-Mlu-067532	Myotis lucifugus	93.64	0.00e+00	898.00
IUUC-Nle-069373	Nomascus leucogenys	94.39	0.00e+00	936.00
IUUC-Opr-070873	Ochotona princeps	90.28	0.00e+00	920.00
IUUC-Ont-072498	Oreochromis niloticus	71.27	0.00e+00	698.00
IUUC-Oan-072943	Ornithorhynchus anatinus	71.59	2.00e-91	329.00
IUUC-Ocu-073870	Oryctolagus cuniculus	93.27	0.00e+00	922.00
IUUC-Ola-086866	Oryzias latipes	89.77	1.00e-104	372.00
IUUC-Oga-089057	Otolemur garnettii	91.21	0.00e+00	882.00
IUUC-Oar-089841	Ovis aries	60.56	2.00e-160	558.00
IUUC-Ptr-091054	Pan troglodytes	94.02	0.00e+00	932.00
IUUC-Pma-094253	Petromyzon marinus	43.56	5.00e-98	351.00
IUUC-Pfo-097179	Poecilia formosa	65.62	7.00e-171	593.00
IUUC-Pab-097702	Pongo abelii	94.39	0.00e+00	936.00
IUUC-Pca-100671	Procavia capensis	84.59	2.00e-117	415.00
IUUC-Rno-106044	Rattus norvegicus	79.35	0.00e+00	793.00
IUUC-Sha-107139	Sarcophilus harrisii	88.96	0.00e+00	846.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	3.50e-02	32.00
IUUC-Ssc-115343	Sus scrofa	91.96	0.00e+00	914.00
IUUC-Tgu-117061	Taeniopygia guttata	89.72	0.00e+00	862.00
IUUC-Tni-119829	Tetraodon nigroviridis	68.08	2.00e-178	619.00
IUUC-Tae-123723	Triticum aestivum	27.50	9.00e-03	35.80
IUUC-Ttr-129148	Tursiops truncatus	91.59	0.00e+00	862.00
IUUC-Vpa-130780	Vicugna pacos	90.09	0.00e+00	840.00
IUUC-Vvi-130966	Vitis vinifera	32.69	5.90e-02	31.20
IUUC-Xtr-132513	Xenopus tropicalis	82.80	0.00e+00	823.00
IUUC-Xma-133904	Xiphophorus maculatus	69.56	0.00e+00	642.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence