iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17205079

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	29.30	2.00e-65	248.00	IUUC-Hsa-045769

Organism

Drosophila melanogaster

Functional Description
(View)

Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria (PubMed:16894030, PubMed:17068333). Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides (PubMed:17068333, PubMed:24374974). Binds, polyubiquitinates and activates Dredd which is required for Rel-mediated induction of antimicrobial peptides (PubMed:22549468). Anti-apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice (PubMed:18166655). Suppresses rpr and hid-dependent cell death in the eye (PubMed:8548811). However, has also been shown to have little, if any, role in the regulation of the canonical caspase-dependent apoptosis pathway (PubMed:17068333). Plays a role in regulating the expression of ion channels (PubMed:24374974).

Protein Sequence
(Fasta)

MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH VRIDRWEYGD 60
QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDNEGNSVVD SPESCSCPDL LLEANRLVTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTAGGTTTG GATATACCGA ATAGCAAGGT AAACTGCTTG ACCTTGTTTT TGTAAGCAGT 60
GCCCATTAAG TTGGTATTTC ATCGATGAAA CATTGACGAT GTATCGAAAA ACATCGATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50089--ZF_RING_2

Pfam

PF00653--BIR

SMART

SM00238--BIR
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0089720--F:caspase binding
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087--P:innate immune response
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0061057--P:peptidoglycan recognition protein signaling pathway
GO:0006964--P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043281--P:regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009966--P:regulation of signal transduction
GO:0007423--P:sensory organ development

KEGG

dme:Dmel_CG8293

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000162	Aegilops tauschii	30.26	7.00e-08	51.20
IUUC-Aml-001990	Ailuropoda melanoleuca	30.74	5.00e-63	234.00
IUUC-Atr-002499	Amborella trichopoda	43.10	4.00e-10	57.80
IUUC-Apl-003549	Anas platyrhynchos	29.61	4.00e-51	195.00
IUUC-Aca-004515	Anolis carolinensis	29.38	9.00e-65	240.00
IUUC-Aly-005858	Arabidopsis lyrata	32.94	2.00e-09	55.80
IUUC-Acl-008330	Aspergillus clavatus	25.00	1.00e-12	67.80
IUUC-Afl-008648	Aspergillus flavus	28.04	1.00e-14	74.70
IUUC-Afu-008813	Aspergillus fumigatus	26.04	3.00e-13	70.10
IUUC-Ani-009424	Aspergillus nidulans	28.88	2.00e-15	77.00
IUUC-Ang-009667	Aspergillus niger	24.12	5.00e-11	62.40
IUUC-Ate-010501	Aspergillus terreus	28.49	1.00e-14	74.30
IUUC-Ame-011877	Astyanax mexicanus	34.53	8.00e-45	174.00
IUUC-Bgr-012051	Blumeria graminis	30.67	8.00e-10	58.50
IUUC-Bta-013246	Bos taurus	30.94	1.00e-62	233.00
IUUC-Bci-013905	Botrytis cinerea	29.82	4.00e-14	72.00
IUUC-Bol-015478	Brassica oleracea	40.35	6.00e-08	54.70
IUUC-Bra-017001	Brassica rapa	29.10	2.00e-08	57.00
IUUC-Cel-018418	Caenorhabditis elegans	38.78	3.00e-06	45.80
IUUC-Cja-018895	Callithrix jacchus	29.24	1.00e-47	183.00
IUUC-Cfa-021117	Canis familiaris	29.79	9.00e-62	230.00
IUUC-Cpo-022048	Cavia porcellus	30.32	6.00e-65	241.00
IUUC-Csa-024159	Chlorocebus sabaeus	29.67	3.00e-67	248.00
IUUC-Cho-024277	Choloepus hoffmanni	27.32	9.00e-45	174.00
IUUC-Cin-025738	Ciona intestinalis	28.99	6.00e-54	205.00
IUUC-Csv-025863	Ciona savignyi	25.06	2.00e-37	148.00
IUUC-Cgl-026472	Colletotrichum gloeosporioides	31.98	2.00e-16	80.90
IUUC-Cne-027029	Cryptococcus neoformans	29.50	6.00e-15	75.10
IUUC-Dre-028647	Danio rerio	29.72	6.00e-49	187.00
IUUC-Dno-029509	Dasypus novemcinctus	28.12	5.00e-49	187.00
IUUC-Dor-030449	Dipodomys ordii	26.24	6.00e-42	164.00
IUUC-Dse-031353	Dothistroma septosporum	29.07	2.00e-12	67.40
IUUC-Ete-032768	Echinops telfairi	28.54	2.00e-45	176.00
IUUC-Eca-033853	Equus caballus	30.15	6.00e-62	230.00
IUUC-Eeu-035114	Erinaceus europaeus	30.54	1.00e-49	190.00
IUUC-Fca-036034	Felis catus	30.00	1.00e-50	193.00
IUUC-Fal-036884	Ficedula albicollis	30.48	3.00e-59	221.00
IUUC-Fox-037889	Fusarium oxysporum	29.24	1.00e-12	68.20
IUUC-Fso-038452	Fusarium solani	29.41	3.00e-11	63.50
IUUC-Gmo-038477	Gadus morhua	30.00	2.00e-48	186.00
IUUC-Ggr-039891	Gaeumannomyces graminis	30.41	6.00e-12	65.90
IUUC-Gga-040601	Gallus gallus	30.55	3.00e-52	199.00
IUUC-Gac-041467	Gasterosteus aculeatus	30.46	2.00e-62	233.00
IUUC-Ggo-044857	Gorilla gorilla	29.42	3.00e-64	238.00
IUUC-Hsa-045769	Homo sapiens	29.59	2.00e-64	239.00
IUUC-Itr-048379	Ictidomys tridecemlineatus	28.89	2.00e-67	249.00
IUUC-Lch-050259	Latimeria chalumnae	30.60	1.00e-65	243.00
IUUC-Loc-052169	Lepisosteus oculatus	34.66	2.00e-44	173.00
IUUC-Laf-053628	Loxodonta africana	30.57	1.00e-62	233.00
IUUC-Mcc-055282	Macaca mulatta	29.67	4.00e-67	248.00
IUUC-Meu-056895	Macropus eugenii	29.85	6.00e-42	164.00
IUUC-Mor-057252	Magnaporthe oryzae	32.14	3.00e-14	73.20
IUUC-Mpo-057489	Magnaporthe poae	31.25	7.00e-13	68.60
IUUC-Mga-059947	Meleagris gallopavo	31.19	3.00e-52	199.00
IUUC-Mvi-060388	Microbotryum violaceum	25.60	2.00e-05	43.90
IUUC-Mmr-060719	Microcebus murinus	27.12	6.00e-66	244.00
IUUC-Mdo-062352	Monodelphis domestica	27.94	4.00e-47	182.00
IUUC-Mmu-064340	Mus musculus	30.92	6.00e-51	194.00
IUUC-Mac-065489	Musa acuminata	39.58	1.00e-06	46.20
IUUC-Mpu-065890	Mustela putorius furo	29.85	8.00e-48	184.00
IUUC-Mlu-068077	Myotis lucifugus	30.41	8.00e-68	250.00
IUUC-Nfi-068591	Neosartorya fischeri	25.51	2.00e-13	70.50
IUUC-Ncr-068787	Neurospora crassa	29.41	6.00e-14	72.00
IUUC-Nle-070081	Nomascus leucogenys	28.15	2.00e-48	186.00
IUUC-Opr-070561	Ochotona princeps	31.46	3.00e-40	159.00
IUUC-Ont-071776	Oreochromis niloticus	29.77	2.00e-64	239.00
IUUC-Oan-073604	Ornithorhynchus anatinus	33.33	2.00e-41	162.00
IUUC-Ocu-074261	Oryctolagus cuniculus	28.27	1.00e-57	216.00
IUUC-Ola-086446	Oryzias latipes	32.76	8.00e-41	160.00
IUUC-Oga-087976	Otolemur garnettii	29.41	6.00e-51	194.00
IUUC-Oar-089496	Ovis aries	30.38	1.00e-51	196.00
IUUC-Ptr-091561	Pan troglodytes	29.74	1.00e-62	233.00
IUUC-Pan-092673	Papio anubis	29.06	3.00e-49	189.00
IUUC-Psi-093862	Pelodiscus sinensis	26.88	1.00e-47	183.00
IUUC-Pma-094277	Petromyzon marinus	29.25	3.00e-48	185.00
IUUC-Ppa-095167	Physcomitrella patens	37.93	3.00e-09	55.50
IUUC-Pfo-096790	Poecilia formosa	35.38	2.00e-44	173.00
IUUC-Pab-098734	Pongo abelii	29.42	2.00e-64	239.00
IUUC-Pca-100708	Procavia capensis	28.46	8.00e-28	117.00
IUUC-Pva-102788	Pteropus vampyrus	32.96	1.00e-41	163.00
IUUC-Pte-104098	Pyrenophora teres	28.40	7.00e-10	57.80
IUUC-Pyt-104561	Pyrenophora triticirepentis	29.59	1.00e-10	60.10
IUUC-Rno-105026	Rattus norvegicus	30.15	3.00e-51	195.00
IUUC-Sha-107229	Sarcophilus harrisii	27.39	4.00e-48	185.00
IUUC-Sja-107720	Schizosaccharomyces japonicus	30.29	4.00e-12	66.60
IUUC-Spo-108317	Schizosaccharomyces pombe	29.73	2.00e-16	80.50
IUUC-Sar-113501	Sorex araneus	29.53	4.00e-59	221.00
IUUC-Ssc-115804	Sus scrofa	28.96	1.00e-65	243.00
IUUC-Tgu-116900	Taeniopygia guttata	30.87	3.00e-47	181.00
IUUC-Tru-117620	Takifugu rubripes	34.29	9.00e-43	167.00
IUUC-Tsy-118923	Tarsius syrichta	33.33	3.00e-46	178.00
IUUC-Tni-119683	Tetraodon nigroviridis	33.45	2.00e-41	163.00
IUUC-Tre-121884	Trichoderma reesei	29.82	4.00e-14	72.80
IUUC-Tvi-122552	Trichoderma virens	28.07	6.00e-13	68.90
IUUC-Tbe-127523	Tupaia belangeri	29.18	3.00e-48	186.00
IUUC-Ttr-128766	Tursiops truncatus	30.47	5.00e-53	201.00
IUUC-Vpa-130436	Vicugna pacos	30.74	4.00e-63	234.00
IUUC-Xtr-132031	Xenopus tropicalis	30.35	3.00e-50	192.00
IUUC-Xma-132984	Xiphophorus maculatus	34.74	3.00e-43	169.00
IUUC-Yli-134629	Yarrowia lipolytica	30.72	4.00e-13	68.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence