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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046079
UUCD1 version UUC-HoS-01151
Ensembl Protein ID ENSP00000258499.3
UniProt Accession Q9H0E7; B2RDW3; UBP44_HUMAN
Genbank Protein ID CAB66759.1; BAG38060.1; AAH30704.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44
Genbank Nucleotide ID AL136825; AK315697; AC018475
Gene Name USP44
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136014.11 ENST00000258499.7 ENSP00000258499.3
ENSG00000136014.11 ENST00000552440.5 ENSP00000448670.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 20402667; 20195072; 17443180; 14715245
Classification
Family E-value Score Start End
DUB/USP 2.10e-97 328.0 273 677
Active Site
Position(s) Description Evidence
282 Nucleophile
636 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp...................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+            +k++      +                                      
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlamtasEKTR------Sckhppvtdtvvyqmnecqekdtgfvcsrqsslssglsg 358
           7******************************8887766665543334......044455799999999999999999999999999999999 PP
   S: 43   ................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeee 118
                           +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         e+
   Q: 359  gaskgrkmeliqpkepTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQREL---------ET 441
           999888888888877666777************************************************************.........78 PP
   S: 119  eeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesftkeeelege 203
           ++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L++ft++e leg+
   Q: 442  TGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqpcLVTEMLAKFTETEALEGK 533
           89999999999************************************************9998877788888889***************96 PP
   S: 204  nkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLia 282
             y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ k+ +  + +Y+L+a
   Q: 534  I-YVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRETLKSLRpeCFIYDLSA 623
           5.*******999999999999999***********************998.7778********************9988876779******* PP
   S: 283  vvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           vv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 624  VVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 677
           ********************9999********************...********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
 Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Protein Sequence
(Fasta)
MLAMDTCKHV GQLQLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN TTGDLKLLRR TLSAIKSQNY HCTTRSGRFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046079|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTTCAGGA AAGCAGTTTC CAGGAGGTGA GAGTTTAAGC CAAACCTGAA AGAGGTTGAT 60
TTGTAATGAT TTGCAGGGGG GCACTGGAGG CAGCCGCCAG GACTTTTCAC TTAGGAGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046079|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0090266--P:regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090231--P:regulation of spindle checkpoint
KEGG hsa:84101
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001220 Ailuropoda melanoleuca 91.16 0.00e+00 1304.00
IUUC-Apl-003673 Anas platyrhynchos 74.79 0.00e+00 1041.00
IUUC-Aca-004434 Anolis carolinensis 73.62 0.00e+00 1002.00
IUUC-Ame-010986 Astyanax mexicanus 64.86 0.00e+00 874.00
IUUC-Bta-012774 Bos taurus 88.64 0.00e+00 1266.00
IUUC-Cja-019619 Callithrix jacchus 93.68 0.00e+00 1324.00
IUUC-Cfa-020957 Canis familiaris 90.04 0.00e+00 1307.00
IUUC-Csa-023177 Chlorocebus sabaeus 94.67 0.00e+00 1335.00
IUUC-Cho-024877 Choloepus hoffmanni 87.18 0.00e+00 828.00
IUUC-Csv-025814 Ciona savignyi 44.16 8.00e-152 530.00
IUUC-Dre-027878 Danio rerio 64.28 0.00e+00 841.00
IUUC-Dno-029832 Dasypus novemcinctus 91.15 0.00e+00 1314.00
IUUC-Ete-032627 Echinops telfairi 86.12 0.00e+00 1247.00
IUUC-Eca-033863 Equus caballus 86.34 0.00e+00 1201.00
IUUC-Eeu-035225 Erinaceus europaeus 85.83 0.00e+00 1189.00
IUUC-Fca-036288 Felis catus 90.88 0.00e+00 1304.00
IUUC-Fal-037207 Ficedula albicollis 74.68 0.00e+00 1000.00
IUUC-Gga-040457 Gallus gallus 73.94 0.00e+00 1011.00
IUUC-Ggo-044926 Gorilla gorilla 98.60 0.00e+00 1390.00
IUUC-Itr-048737 Ictidomys tridecemlineatus 90.45 0.00e+00 1290.00
IUUC-Lch-050260 Latimeria chalumnae 66.57 0.00e+00 913.00
IUUC-Laf-054491 Loxodonta africana 88.41 0.00e+00 1216.00
IUUC-Mcc-055694 Macaca mulatta 94.95 0.00e+00 1334.00
IUUC-Mga-059523 Meleagris gallopavo 73.63 0.00e+00 1023.00
IUUC-Mmr-060885 Microcebus murinus 93.55 0.00e+00 1340.00
IUUC-Mdo-063018 Monodelphis domestica 79.07 0.00e+00 1108.00
IUUC-Mmu-064012 Mus musculus 80.06 0.00e+00 1098.00
IUUC-Mpu-066207 Mustela putorius furo 89.20 0.00e+00 1305.00
IUUC-Mlu-066929 Myotis lucifugus 86.34 0.00e+00 1174.00
IUUC-Nle-069313 Nomascus leucogenys 87.10 0.00e+00 1186.00
IUUC-Opr-070375 Ochotona princeps 81.49 0.00e+00 1116.00
IUUC-Ont-071637 Oreochromis niloticus 63.52 0.00e+00 860.00
IUUC-Oan-073030 Ornithorhynchus anatinus 77.84 0.00e+00 842.00
IUUC-Ocu-074836 Oryctolagus cuniculus 87.59 0.00e+00 1253.00
IUUC-Oga-088367 Otolemur garnettii 92.15 0.00e+00 1299.00
IUUC-Oar-089953 Ovis aries 89.50 0.00e+00 1292.00
IUUC-Ptr-090980 Pan troglodytes 99.02 0.00e+00 1392.00
IUUC-Pan-092748 Papio anubis 95.37 0.00e+00 1338.00
IUUC-Pfo-096860 Poecilia formosa 70.57 5.00e-170 591.00
IUUC-Pab-098514 Pongo abelii 97.34 0.00e+00 1367.00
IUUC-Pva-102984 Pteropus vampyrus 87.94 0.00e+00 1228.00
IUUC-Rno-106019 Rattus norvegicus 80.42 0.00e+00 1134.00
IUUC-Sha-106965 Sarcophilus harrisii 77.70 0.00e+00 1097.00
IUUC-Ssc-115299 Sus scrofa 90.46 0.00e+00 1311.00
IUUC-Tgu-117160 Taeniopygia guttata 73.72 0.00e+00 1001.00
IUUC-Tru-118156 Takifugu rubripes 60.82 0.00e+00 825.00
IUUC-Tni-119733 Tetraodon nigroviridis 61.64 0.00e+00 848.00
IUUC-Tbe-128084 Tupaia belangeri 85.81 0.00e+00 1212.00
IUUC-Ttr-128928 Tursiops truncatus 91.30 0.00e+00 1322.00
IUUC-Vpa-130706 Vicugna pacos 90.88 0.00e+00 1303.00
IUUC-Xtr-132061 Xenopus tropicalis 71.54 0.00e+00 926.00
Created Date 25-Jun-2017

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