iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062173

UUCD1 version

UUC-MoD-00570

Ensembl Protein ID

ENSMODP00000025569.3

UniProt Accession

F7AR59; F7AR59_MONDO

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000020439.3	ENSMODT00000026021.3	ENSMODP00000025569.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-135	451.1	660	991

Active Site

Position(s)	Description	Evidence
961	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 660  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 748
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 749  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 832
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d+++++ yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 833  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHAIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 921
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 922  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 991
           *********************************************************************8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGACCG GGCTGGGGGA GCCAGTCTAT GGACTTTCGG AAGATGAAGT AAGTGATTTA 60
CTCCCCCATA CCTCCCGTGA ATTGGTATGC TTACCCTAAG CCCATCTGTC ACCCTCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	92.72	0.00e+00	1672.00
IUUC-Apl-003893	Anas platyrhynchos	92.61	0.00e+00	1704.00
IUUC-Aca-004744	Anolis carolinensis	89.75	0.00e+00	1663.00
IUUC-Acl-008273	Aspergillus clavatus	46.97	2.00e-159	556.00
IUUC-Afl-008713	Aspergillus flavus	45.08	2.00e-157	549.00
IUUC-Afu-009103	Aspergillus fumigatus	47.38	9.00e-160	557.00
IUUC-Ani-009259	Aspergillus nidulans	46.91	9.00e-158	550.00
IUUC-Ang-009738	Aspergillus niger	47.65	8.00e-158	550.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	45.86	3.00e-160	558.00
IUUC-Ame-010810	Astyanax mexicanus	70.74	0.00e+00	1244.00
IUUC-Bta-012679	Bos taurus	93.98	0.00e+00	1579.00
IUUC-Bci-013785	Botrytis cinerea	46.37	2.00e-152	532.00
IUUC-Cel-018564	Caenorhabditis elegans	50.81	8.00e-178	617.00
IUUC-Cja-018732	Callithrix jacchus	95.58	0.00e+00	1823.00
IUUC-Cfa-021226	Canis familiaris	94.79	0.00e+00	1773.00
IUUC-Cpo-021671	Cavia porcellus	92.95	0.00e+00	1729.00
IUUC-Csa-023344	Chlorocebus sabaeus	97.28	0.00e+00	1860.00
IUUC-Cho-024832	Choloepus hoffmanni	99.72	0.00e+00	743.00
IUUC-Cin-025157	Ciona intestinalis	61.87	0.00e+00	777.00
IUUC-Dre-027770	Danio rerio	76.98	0.00e+00	1437.00
IUUC-Dno-029466	Dasypus novemcinctus	95.27	0.00e+00	1821.00
IUUC-Dor-030138	Dipodomys ordii	89.93	0.00e+00	1639.00
IUUC-Dse-031241	Dothistroma septosporum	46.82	2.00e-155	543.00
IUUC-Ete-033145	Echinops telfairi	86.18	0.00e+00	1270.00
IUUC-Eca-033445	Equus caballus	95.08	0.00e+00	1571.00
IUUC-Eeu-035247	Erinaceus europaeus	86.61	0.00e+00	1476.00
IUUC-Fca-035489	Felis catus	91.81	0.00e+00	1523.00
IUUC-Fal-037604	Ficedula albicollis	93.20	0.00e+00	1769.00
IUUC-Fox-037774	Fusarium oxysporum	46.96	1.00e-154	540.00
IUUC-Gmo-039674	Gadus morhua	75.02	0.00e+00	1387.00
IUUC-Gga-040703	Gallus gallus	91.75	0.00e+00	1753.00
IUUC-Gac-042020	Gasterosteus aculeatus	78.72	0.00e+00	1435.00
IUUC-Ggo-045332	Gorilla gorilla	93.51	0.00e+00	1715.00
IUUC-Hsa-045968	Homo sapiens	95.67	0.00e+00	1819.00
IUUC-Lch-050443	Latimeria chalumnae	85.21	0.00e+00	1438.00
IUUC-Loc-052662	Lepisosteus oculatus	79.12	0.00e+00	1449.00
IUUC-Laf-053850	Loxodonta africana	93.87	0.00e+00	1764.00
IUUC-Mcc-055821	Macaca mulatta	95.39	0.00e+00	1779.00
IUUC-Meu-056712	Macropus eugenii	82.00	0.00e+00	790.00
IUUC-Mla-058996	Melampsora laricipopulina	45.25	2.00e-151	529.00
IUUC-Mga-059362	Meleagris gallopavo	62.03	0.00e+00	1133.00
IUUC-Mmr-060798	Microcebus murinus	91.34	0.00e+00	1659.00
IUUC-Mmu-064136	Mus musculus	94.57	0.00e+00	1783.00
IUUC-Mpu-066765	Mustela putorius furo	95.09	0.00e+00	1759.00
IUUC-Mlu-067565	Myotis lucifugus	92.87	0.00e+00	1558.00
IUUC-Nfi-068427	Neosartorya fischeri	47.38	8.00e-160	557.00
IUUC-Ncr-068918	Neurospora crassa	46.10	3.00e-152	532.00
IUUC-Nle-069070	Nomascus leucogenys	92.36	0.00e+00	1727.00
IUUC-Opr-071044	Ochotona princeps	92.92	0.00e+00	1183.00
IUUC-Ont-072044	Oreochromis niloticus	76.92	0.00e+00	1476.00
IUUC-Oan-073032	Ornithorhynchus anatinus	91.87	0.00e+00	1443.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.94	0.00e+00	1709.00
IUUC-Ola-087467	Oryzias latipes	78.61	0.00e+00	1464.00
IUUC-Oga-088460	Otolemur garnettii	90.62	0.00e+00	1555.00
IUUC-Oar-090198	Ovis aries	94.08	0.00e+00	1743.00
IUUC-Ptr-090939	Pan troglodytes	95.67	0.00e+00	1819.00
IUUC-Pan-092284	Papio anubis	95.57	0.00e+00	1816.00
IUUC-Psi-093645	Pelodiscus sinensis	93.16	0.00e+00	1766.00
IUUC-Pma-094364	Petromyzon marinus	79.27	0.00e+00	848.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.36	6.00e-160	558.00
IUUC-Pfo-096768	Poecilia formosa	87.54	0.00e+00	949.00
IUUC-Pab-098088	Pongo abelii	95.22	0.00e+00	1788.00
IUUC-Pca-100714	Procavia capensis	73.57	0.00e+00	1292.00
IUUC-Pva-102354	Pteropus vampyrus	92.86	0.00e+00	1667.00
IUUC-Ptt-103806	Puccinia triticina	50.81	8.00e-119	421.00
IUUC-Pte-104016	Pyrenophora teres	47.02	4.00e-158	551.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	47.02	4.00e-158	551.00
IUUC-Rno-105318	Rattus norvegicus	93.78	0.00e+00	1736.00
IUUC-Sha-107482	Sarcophilus harrisii	96.56	0.00e+00	1672.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.85	5.00e-154	538.00
IUUC-Ssc-115950	Sus scrofa	69.37	0.00e+00	1166.00
IUUC-Tgu-117130	Taeniopygia guttata	92.63	0.00e+00	1736.00
IUUC-Tru-118610	Takifugu rubripes	78.78	0.00e+00	1484.00
IUUC-Tsy-119492	Tarsius syrichta	89.50	0.00e+00	1625.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.86	0.00e+00	1360.00
IUUC-Tvi-122595	Trichoderma virens	45.57	9.00e-150	524.00
IUUC-Tbe-127441	Tupaia belangeri	85.37	0.00e+00	768.00
IUUC-Ttr-128235	Tursiops truncatus	85.33	0.00e+00	1490.00
IUUC-Vpa-130544	Vicugna pacos	71.43	0.00e+00	848.00
IUUC-Xtr-132859	Xenopus tropicalis	88.09	0.00e+00	1652.00
IUUC-Xma-133797	Xiphophorus maculatus	79.48	0.00e+00	1476.00
IUUC-Yli-134668	Yarrowia lipolytica	44.75	2.00e-157	550.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence