• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045991
UUCD1 version UUC-HoS-00166
Ensembl Protein ID ENSP00000354361.4
UniProt Accession Q6PCD5; A8K585; B2RE35; D3DUJ8; Q5XKR3; Q9H9Q3; Q9NVT4; RFWD3_HUMAN
Genbank Protein ID BAA91662.1; BAB14169.1; BAF83889.1; BAG38132.1; EAW95680.1; EAW95681.1; AAH02574.2; AAH59371.2
Protein Name E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3
Genbank Nucleotide ID AK001382; AK022673; AK291200; AK315786; AC109599; CH471114; BC002574; BC059371
Gene Name RFWD3; RNF201
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168411.13 ENST00000361070.8 ENSP00000354361.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20173098
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0055 18.9 287 331
E3 adaptor/Cullin RING/DCX/DWD 2.60e-08 35.5 496 534
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle      ++ +  l+CgH+f   C+  w     ++ +  +CP C+
   Q: 287  CTICLEQWtnagDHRLSALRCGHLFGYRCISTW-----LKGQVRKCPQCN 331
           9*****99777633388899*************.....5566668***96 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtgvllk 37
           H   +++laf s   +ll+s+s D+tik+ +l t+++++
   Q: 496  HGKQIRGLAFsSYlrGLLLSASLDNTIKLTSLETNTVVQ 534
           8889******8445599***********98888877766 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
 E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
Protein Sequence
(Fasta)
MAHEAMEYDV QVQLNHAEQQ PAPAGMASSQ GGPALLQPVP ADVVSSQGVP SILQPAPAEV 60
ISSQATPPLL QPAPQLSVDL TEVEVLGEDT VENINPRTSE QHRQGSDGNH TIPASSLHSM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045991|E3,RING;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGTGGCAGT TGGCGTAGGT GCATTCGGAG TGCGGCCGAG GTAACTACCG AGTCTTCGGC 60
GGGCTCGCGA GCCCGGCCGC GGCCTGCTGG TTTCAGGTGA GGAGGGGTGT TGCTTCTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045991|E3,RING;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0097371--F:MDM2/MDM4 family protein binding
GO:0002039--F:p53 binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0016567--P:protein ubiquitination
GO:2000001--P:regulation of DNA damage checkpoint
GO:0010212--P:response to ionizing radiation
KEGG hsa:55159
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000929 Aegilops tauschii 23.22 2.00e-15 77.40
IUUC-Aml-001188 Ailuropoda melanoleuca 78.85 0.00e+00 1139.00
IUUC-Atr-003034 Amborella trichopoda 26.86 7.00e-17 81.30
IUUC-Apl-003182 Anas platyrhynchos 61.58 0.00e+00 719.00
IUUC-Aca-004619 Anolis carolinensis 69.23 0.00e+00 737.00
IUUC-Aly-006391 Arabidopsis lyrata 28.98 5.00e-30 126.00
IUUC-Ath-007300 Arabidopsis thaliana 28.75 2.00e-29 124.00
IUUC-Ame-010890 Astyanax mexicanus 59.72 0.00e+00 633.00
IUUC-Bta-013051 Bos taurus 73.16 0.00e+00 1046.00
IUUC-Bdi-014519 Brachypodium distachyon 27.16 2.00e-20 94.00
IUUC-Bol-015271 Brassica oleracea 29.81 4.00e-30 126.00
IUUC-Bra-017931 Brassica rapa 30.12 2.00e-29 124.00
IUUC-Cja-019240 Callithrix jacchus 87.73 0.00e+00 1264.00
IUUC-Cfa-021010 Canis familiaris 76.71 0.00e+00 1125.00
IUUC-Cpo-022308 Cavia porcellus 72.40 0.00e+00 966.00
IUUC-Csa-023501 Chlorocebus sabaeus 95.99 0.00e+00 1472.00
IUUC-Cho-024900 Choloepus hoffmanni 67.95 0.00e+00 997.00
IUUC-Cin-025403 Ciona intestinalis 36.80 1.00e-94 340.00
IUUC-Csv-025819 Ciona savignyi 37.11 2.00e-44 172.00
IUUC-Cme-027123 Cyanidioschyzon merolae 25.47 1.00e-19 91.70
IUUC-Dre-028354 Danio rerio 57.23 2.00e-166 578.00
IUUC-Dno-029400 Dasypus novemcinctus 76.91 0.00e+00 1053.00
IUUC-Dor-030320 Dipodomys ordii 73.38 0.00e+00 838.00
IUUC-Dme-031949 Drosophila melanogaster 27.19 1.00e-44 174.00
IUUC-Ete-032691 Echinops telfairi 56.78 1.00e-140 494.00
IUUC-Eca-034320 Equus caballus 80.18 0.00e+00 1219.00
IUUC-Fca-035732 Felis catus 77.79 0.00e+00 1084.00
IUUC-Fal-036648 Ficedula albicollis 69.90 0.00e+00 728.00
IUUC-Gmo-038609 Gadus morhua 56.67 4.00e-140 491.00
IUUC-Gga-040522 Gallus gallus 70.00 1.00e-106 380.00
IUUC-Gac-042318 Gasterosteus aculeatus 55.77 1.00e-134 473.00
IUUC-Gma-043184 Glycine max 26.58 1.00e-25 111.00
IUUC-Ggo-044464 Gorilla gorilla 98.71 0.00e+00 1491.00
IUUC-Hvu-047705 Hordeum vulgare 23.93 6.00e-27 115.00
IUUC-Itr-047977 Ictidomys tridecemlineatus 79.38 0.00e+00 1161.00
IUUC-Lch-050112 Latimeria chalumnae 64.47 0.00e+00 668.00
IUUC-Lpe-051605 Leersia perrieri 26.96 3.00e-17 83.60
IUUC-Loc-052241 Lepisosteus oculatus 63.89 0.00e+00 648.00
IUUC-Laf-054559 Loxodonta africana 74.71 0.00e+00 952.00
IUUC-Mcc-055093 Macaca mulatta 95.35 0.00e+00 1442.00
IUUC-Meu-056417 Macropus eugenii 65.42 0.00e+00 684.00
IUUC-Mtr-058533 Medicago truncatula 26.61 7.00e-31 129.00
IUUC-Mga-059498 Meleagris gallopavo 60.94 0.00e+00 712.00
IUUC-Mmr-061782 Microcebus murinus 75.80 0.00e+00 1128.00
IUUC-Mdo-062053 Monodelphis domestica 71.92 0.00e+00 759.00
IUUC-Mmu-063352 Mus musculus 66.32 0.00e+00 985.00
IUUC-Mac-064582 Musa acuminata 26.09 1.00e-20 94.70
IUUC-Mpu-066087 Mustela putorius furo 76.48 0.00e+00 1132.00
IUUC-Mlu-068147 Myotis lucifugus 74.87 0.00e+00 1033.00
IUUC-Nle-069503 Nomascus leucogenys 93.93 0.00e+00 1404.00
IUUC-Opr-070479 Ochotona princeps 67.91 0.00e+00 986.00
IUUC-Ont-071700 Oreochromis niloticus 58.85 2.00e-173 602.00
IUUC-Oan-073702 Ornithorhynchus anatinus 74.19 0.00e+00 778.00
IUUC-Ocu-074886 Oryctolagus cuniculus 74.52 0.00e+00 1109.00
IUUC-Oba-075729 Oryza barthii 28.48 3.00e-24 106.00
IUUC-Obr-076562 Oryza brachyantha 26.52 4.00e-20 93.20
IUUC-Ogl-077615 Oryza glaberrima 28.48 3.00e-24 106.00
IUUC-Ogu-078921 Oryza glumaepatula 28.16 6.00e-24 105.00
IUUC-Oin-079250 Oryza indica 26.98 3.00e-17 83.60
IUUC-Olo-080758 Oryza longistaminata 26.38 3.00e-22 100.00
IUUC-Ome-081707 Oryza meridionalis 27.62 5.00e-19 89.40
IUUC-Oni-083006 Oryza nivara 28.16 1.00e-23 105.00
IUUC-Opu-083650 Oryza punctata 28.21 1.00e-23 104.00
IUUC-Oru-084924 Oryza rufipogon 27.96 4.00e-24 106.00
IUUC-Osa-085820 Oryza sativa 28.16 1.00e-23 105.00
IUUC-Ola-087229 Oryzias latipes 58.10 2.00e-139 488.00
IUUC-Oga-088243 Otolemur garnettii 73.11 0.00e+00 1038.00
IUUC-Oar-089461 Ovis aries 75.29 0.00e+00 1130.00
IUUC-Ptr-090527 Pan troglodytes 99.10 0.00e+00 1485.00
IUUC-Pan-092431 Papio anubis 95.60 0.00e+00 1375.00
IUUC-Psi-093156 Pelodiscus sinensis 55.08 0.00e+00 768.00
IUUC-Pno-094897 Phaeosphaeria nodorum 24.58 4.00e-08 52.40
IUUC-Ppa-095305 Physcomitrella patens 40.71 2.00e-19 92.00
IUUC-Pfo-097065 Poecilia formosa 57.49 3.00e-166 578.00
IUUC-Pab-098272 Pongo abelii 97.80 0.00e+00 1503.00
IUUC-Pop-099827 Populus trichocarpa 29.64 3.00e-33 137.00
IUUC-Pca-100713 Procavia capensis 63.71 0.00e+00 913.00
IUUC-Ppe-102103 Prunus persica 24.53 7.00e-32 132.00
IUUC-Pva-103133 Pteropus vampyrus 83.37 0.00e+00 728.00
IUUC-Ptt-103972 Puccinia triticina 27.41 8.00e-06 45.40
IUUC-Sha-107628 Sarcophilus harrisii 56.85 0.00e+00 805.00
IUUC-Sit-109781 Setaria italica 29.90 9.00e-25 108.00
IUUC-Sly-111779 Solanum lycopersicum 31.73 1.00e-32 135.00
IUUC-Stu-112817 Solanum tuberosum 42.61 1.00e-18 87.00
IUUC-Sar-113124 Sorex araneus 63.09 0.00e+00 687.00
IUUC-Sbi-114107 Sorghum bicolor 24.28 6.00e-27 115.00
IUUC-Sre-115057 Sporisorium reilianum 33.33 5.00e-06 46.60
IUUC-Ssc-115850 Sus scrofa 76.43 0.00e+00 1112.00
IUUC-Tgu-117295 Taeniopygia guttata 69.55 0.00e+00 740.00
IUUC-Tru-117539 Takifugu rubripes 56.07 3.00e-169 588.00
IUUC-Tsy-118805 Tarsius syrichta 71.62 2.00e-113 403.00
IUUC-Tni-120274 Tetraodon nigroviridis 58.70 1.00e-169 589.00
IUUC-Tca-121162 Theobroma cacao 30.96 1.00e-29 124.00
IUUC-Tae-124822 Triticum aestivum 24.39 9.00e-28 118.00
IUUC-Tur-126162 Triticum urartu 25.00 2.00e-16 81.30
IUUC-Tbe-127884 Tupaia belangeri 72.69 1.00e-83 304.00
IUUC-Ttr-128665 Tursiops truncatus 71.84 0.00e+00 986.00
IUUC-Uma-129349 Ustilago maydis 33.33 2.00e-06 47.80
IUUC-Vpa-130385 Vicugna pacos 79.54 0.00e+00 1129.00
IUUC-Vvi-131464 Vitis vinifera 29.41 3.00e-25 110.00
IUUC-Xtr-132015 Xenopus tropicalis 61.12 0.00e+00 711.00
IUUC-Xma-133109 Xiphophorus maculatus 57.92 3.00e-166 578.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved