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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046276
UUCD1 version UUC-HoS-00317
Ensembl Protein ID ENSP00000487399.1
UniProt Accession Q96Q27; B2RDP9; B4E166; Q9NSU5; Q9Y567; ASB2_HUMAN
Genbank Protein ID BAB64532.1; CAC17765.1; BAI77868.1; BAG64678.1; BAG37996.1; EAW81540.1; EAW81542.1; AAH32354.1; CAB70899.1; AAD45345.1
Protein Name Ankyrin repeat and SOCS box protein 2
Genbank Nucleotide ID AB056723; AJ251238; AB488462; AK303686; AK315628; AL079302; CH471061; BC032354; AL137735; AF159164
Gene Name ASB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000278693.3 ENST00000612647.3 ENSP00000480388.1
ENSG00000278693.3 ENST00000629617.2 ENSP00000487399.1
ENSG00000278693.3 ENST00000626296.2 ENSP00000486398.1
ENSG00000278693.3 ENST00000626017.2 ENSP00000487497.1
ENSG00000278693.3 ENST00000625949.1 ENSP00000487105.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
TCGAICGCCOSMICHPM
DNA & RNA Element
UTRdbCircNetRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16325183; 19376791; 21119685; 24052262
UBD/Alpha-Helix/UIM UIM 22382022
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.30e-17 65.0 535 586
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++ +++  + pr+L hLCRl++r+++g++r+k++d+LPLP +L++YL+ye++
   Q: 535  WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENT 586
           567899999*****************************************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.
 Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.
Protein Sequence
(Fasta)
MTRFSYAEYF SLFHSCSAPS RSTAPPESSP ARAPMGLFQG VMQKYSSSLF KTSQLAPADP 60
LIKAIKDGDE EALKTMIKEG KNLAEPNKEG WLPLHEAAYY GQVGCLKVLQ RAYPGTIDQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046276|E3,SOCS;UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAAATGATG ACATCACGTG AGGGCCAAAG CTCCGGGATC CTCTCTGAAG TGAGAGTCTG 60
TATTCGATGC ACCCGGAGGA ACGGAAGGCA GGATTGCAGC TTCCTCAGTG CAACCTCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046276|E3,SOCS;UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF13606--Ank_3
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0035556--P:intracellular signal transduction
GO:0045445--P:myoblast differentiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0035914--P:skeletal muscle cell differentiation
KEGG hsa:51676
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002426 Ailuropoda melanoleuca 88.77 0.00e+00 1048.00
IUUC-Apl-003289 Anas platyrhynchos 72.84 0.00e+00 875.00
IUUC-Aca-004685 Anolis carolinensis 72.21 0.00e+00 851.00
IUUC-Ame-011522 Astyanax mexicanus 58.06 0.00e+00 659.00
IUUC-Bta-012533 Bos taurus 89.79 0.00e+00 1046.00
IUUC-Cja-018887 Callithrix jacchus 96.75 0.00e+00 1120.00
IUUC-Cfa-020241 Canis familiaris 87.50 0.00e+00 983.00
IUUC-Cpo-021586 Cavia porcellus 89.26 0.00e+00 1022.00
IUUC-Csa-024206 Chlorocebus sabaeus 97.36 0.00e+00 1130.00
IUUC-Csv-025944 Ciona savignyi 37.70 6.00e-91 328.00
IUUC-Dre-028150 Danio rerio 55.99 0.00e+00 646.00
IUUC-Dno-029859 Dasypus novemcinctus 87.89 0.00e+00 1007.00
IUUC-Dor-030375 Dipodomys ordii 81.26 0.00e+00 891.00
IUUC-Dme-031775 Drosophila melanogaster 28.72 6.00e-37 150.00
IUUC-Ete-032832 Echinops telfairi 89.50 0.00e+00 947.00
IUUC-Eca-033752 Equus caballus 90.49 0.00e+00 1051.00
IUUC-Eeu-034810 Erinaceus europaeus 81.73 2.00e-141 496.00
IUUC-Fca-036306 Felis catus 87.06 0.00e+00 1018.00
IUUC-Fal-037401 Ficedula albicollis 72.82 0.00e+00 867.00
IUUC-Gga-040683 Gallus gallus 74.28 0.00e+00 873.00
IUUC-Gac-041891 Gasterosteus aculeatus 47.32 1.00e-156 546.00
IUUC-Ggo-044676 Gorilla gorilla 99.47 0.00e+00 1174.00
IUUC-Itr-048291 Ictidomys tridecemlineatus 88.42 0.00e+00 1049.00
IUUC-Lch-050470 Latimeria chalumnae 68.45 0.00e+00 783.00
IUUC-Loc-052826 Lepisosteus oculatus 61.25 0.00e+00 709.00
IUUC-Laf-053868 Loxodonta africana 88.56 0.00e+00 1058.00
IUUC-Mcc-054926 Macaca mulatta 97.18 0.00e+00 1129.00
IUUC-Meu-056671 Macropus eugenii 77.17 0.00e+00 957.00
IUUC-Mga-059782 Meleagris gallopavo 73.73 0.00e+00 866.00
IUUC-Mmr-061793 Microcebus murinus 92.03 0.00e+00 1061.00
IUUC-Mdo-062521 Monodelphis domestica 80.11 0.00e+00 977.00
IUUC-Mmu-063801 Mus musculus 91.20 0.00e+00 1082.00
IUUC-Mpu-066868 Mustela putorius furo 87.68 0.00e+00 1023.00
IUUC-Mlu-067101 Myotis lucifugus 87.37 0.00e+00 971.00
IUUC-Nle-069551 Nomascus leucogenys 98.59 0.00e+00 1165.00
IUUC-Opr-071102 Ochotona princeps 91.14 0.00e+00 1092.00
IUUC-Ont-071648 Oreochromis niloticus 53.39 3.00e-170 592.00
IUUC-Oan-073719 Ornithorhynchus anatinus 77.29 0.00e+00 945.00
IUUC-Ocu-074019 Oryctolagus cuniculus 89.23 0.00e+00 1016.00
IUUC-Oga-088029 Otolemur garnettii 92.97 0.00e+00 1055.00
IUUC-Oar-090209 Ovis aries 70.84 0.00e+00 752.00
IUUC-Ptr-090635 Pan troglodytes 99.30 0.00e+00 1170.00
IUUC-Pan-092406 Papio anubis 97.18 0.00e+00 1129.00
IUUC-Psi-093322 Pelodiscus sinensis 74.82 0.00e+00 891.00
IUUC-Pma-094270 Petromyzon marinus 47.04 9.00e-142 497.00
IUUC-Pfo-096482 Poecilia formosa 46.90 7.00e-132 464.00
IUUC-Pab-097967 Pongo abelii 99.10 0.00e+00 1137.00
IUUC-Pca-100765 Procavia capensis 86.49 0.00e+00 1041.00
IUUC-Pva-102807 Pteropus vampyrus 88.76 0.00e+00 1035.00
IUUC-Rno-104953 Rattus norvegicus 92.64 0.00e+00 1080.00
IUUC-Sha-107217 Sarcophilus harrisii 80.63 0.00e+00 986.00
IUUC-Smo-109436 Selaginella moellendorffii 25.33 2.00e-13 70.50
IUUC-Ssc-116227 Sus scrofa 86.95 0.00e+00 1011.00
IUUC-Tgu-116733 Taeniopygia guttata 74.20 0.00e+00 884.00
IUUC-Tru-117954 Takifugu rubripes 55.47 7.00e-168 584.00
IUUC-Tbe-127564 Tupaia belangeri 89.00 0.00e+00 1048.00
IUUC-Ttr-128996 Tursiops truncatus 88.25 0.00e+00 1083.00
IUUC-Xtr-132772 Xenopus tropicalis 65.59 0.00e+00 770.00
Created Date 25-Jun-2017

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