iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089490

Ensembl Protein ID

ENSOARP00000008928.1

UniProt Accession

W5PER4; W5PER4_SHEEP

Genbank Protein ID

ENSOARP00000008928

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01074712

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000008319.1	ENSOART00000009058.1	ENSOARP00000008928.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-111	373.0	145	671

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..eknkpkeeeeeedkselsde.............................................. 129
           qqD+qEfl++l+dql+eelk+   ++++++e++e d+s ++de                                              
   Q: 229  QQDTQEFLRCLMDQLHEELKEpvVATSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrsgggsqaeaellladeagraisekermk 317
           *******************9988788888888888888888889********************************************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  drkfswgqqrtnseqvdedadvdtamaaleqqppetqppsprstspcrtpepdneahmrstsrpcspvhhheghtklassphraspvrm 406
           ***************************************************************************************** PP
   S: 130  .............aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.................... 185
                        ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+                    
   Q: 407  gpqdavppaqvpsSRRRKEQSYRSVISDIFDGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqnvpakpgacgdsya 495
           *************99*************************************************99888******************** PP
   S: 186  .............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqks 245
                                        +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf  ++e + 
   Q: 496  aqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF--RHEVMY 582
           *********************************************************************************..9999** PP
   S: 246  rekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYv 332
           + ki+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++   ++aYv
   Q: 583  SFKISSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN---AEAYV 666
           *************************999..9**************************78999*******************...***** PP
   S: 333  lfYkr 337
           lfY++
   Q: 667  LFYRK 671
           ***98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MGDSRDLCPH LDSIGEVTKE DLLLKSKSTC QSCGVSGPNL WACLQVSCSY VGCGESFADH 60
STLHAQAKKH NLTVNLTTLR VWCYACEKEV LLQPRLATHP PGPAPKFSEQ DSPPPSPPLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGACT CCAGGGACCT TTGTCCTCAT CTTGACTCGA TAGGGGAGGT GACCAAAGAG 60
GACTTGCTGC TCAAATCCAA GGTAAAGGGT CAGACCTTCC GGGGCGGAGG CCCACACCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	88.42	0.00e+00	1550.00
IUUC-Apl-003351	Anas platyrhynchos	81.93	0.00e+00	1467.00
IUUC-Aca-005077	Anolis carolinensis	73.01	0.00e+00	1016.00
IUUC-Ame-011777	Astyanax mexicanus	71.95	0.00e+00	1231.00
IUUC-Bta-013063	Bos taurus	93.32	0.00e+00	1600.00
IUUC-Cja-019868	Callithrix jacchus	87.76	0.00e+00	1571.00
IUUC-Cfa-020761	Canis familiaris	88.63	0.00e+00	1566.00
IUUC-Cpo-022267	Cavia porcellus	82.10	0.00e+00	1422.00
IUUC-Csa-024251	Chlorocebus sabaeus	88.62	0.00e+00	1582.00
IUUC-Cho-024483	Choloepus hoffmanni	92.93	1.00e-108	387.00
IUUC-Dre-028061	Danio rerio	70.58	0.00e+00	1109.00
IUUC-Dno-029423	Dasypus novemcinctus	89.17	0.00e+00	1564.00
IUUC-Dor-030877	Dipodomys ordii	86.67	0.00e+00	979.00
IUUC-Ete-032802	Echinops telfairi	77.30	6.00e-133	468.00
IUUC-Eca-034283	Equus caballus	87.32	0.00e+00	1547.00
IUUC-Eeu-034620	Erinaceus europaeus	87.87	0.00e+00	1149.00
IUUC-Fca-036357	Felis catus	89.51	0.00e+00	1540.00
IUUC-Fal-037411	Ficedula albicollis	81.91	0.00e+00	1462.00
IUUC-Gga-041101	Gallus gallus	81.17	0.00e+00	1440.00
IUUC-Gac-041315	Gasterosteus aculeatus	70.95	0.00e+00	1220.00
IUUC-Ggo-045600	Gorilla gorilla	87.92	0.00e+00	1518.00
IUUC-Hsa-045825	Homo sapiens	88.51	0.00e+00	1533.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	75.35	0.00e+00	1261.00
IUUC-Lch-050002	Latimeria chalumnae	73.93	0.00e+00	1268.00
IUUC-Loc-052574	Lepisosteus oculatus	74.92	0.00e+00	1310.00
IUUC-Laf-054428	Loxodonta africana	87.13	0.00e+00	1538.00
IUUC-Mcc-055736	Macaca mulatta	88.40	0.00e+00	1576.00
IUUC-Mga-059781	Meleagris gallopavo	80.77	0.00e+00	1442.00
IUUC-Mdo-063048	Monodelphis domestica	81.78	0.00e+00	1414.00
IUUC-Mmu-064079	Mus musculus	87.01	0.00e+00	1536.00
IUUC-Mpu-066616	Mustela putorius furo	87.35	0.00e+00	1580.00
IUUC-Mlu-067294	Myotis lucifugus	87.43	0.00e+00	1478.00
IUUC-Nle-070015	Nomascus leucogenys	88.40	0.00e+00	1507.00
IUUC-Opr-070328	Ochotona princeps	87.65	0.00e+00	1555.00
IUUC-Ont-071464	Oreochromis niloticus	72.52	0.00e+00	1220.00
IUUC-Oan-073259	Ornithorhynchus anatinus	74.08	0.00e+00	1208.00
IUUC-Ocu-074630	Oryctolagus cuniculus	85.61	0.00e+00	1472.00
IUUC-Ola-087240	Oryzias latipes	71.80	0.00e+00	1202.00
IUUC-Oga-088761	Otolemur garnettii	87.20	0.00e+00	1546.00
IUUC-Ptr-091662	Pan troglodytes	88.62	0.00e+00	1534.00
IUUC-Pan-092199	Papio anubis	88.21	0.00e+00	1570.00
IUUC-Psi-093726	Pelodiscus sinensis	82.31	0.00e+00	1466.00
IUUC-Pma-094389	Petromyzon marinus	63.30	5.00e-99	353.00
IUUC-Pfo-096522	Poecilia formosa	70.88	0.00e+00	913.00
IUUC-Pab-098632	Pongo abelii	88.18	0.00e+00	1521.00
IUUC-Pca-100614	Procavia capensis	81.29	0.00e+00	1192.00
IUUC-Pva-102922	Pteropus vampyrus	88.30	0.00e+00	945.00
IUUC-Rno-105215	Rattus norvegicus	86.99	0.00e+00	1541.00
IUUC-Sha-106601	Sarcophilus harrisii	81.18	0.00e+00	1390.00
IUUC-Ssc-115533	Sus scrofa	87.88	0.00e+00	1532.00
IUUC-Tgu-117364	Taeniopygia guttata	81.85	0.00e+00	1427.00
IUUC-Tru-117770	Takifugu rubripes	70.33	0.00e+00	1207.00
IUUC-Tni-120001	Tetraodon nigroviridis	71.46	0.00e+00	1186.00
IUUC-Ttr-128732	Tursiops truncatus	90.49	0.00e+00	1564.00
IUUC-Xtr-132157	Xenopus tropicalis	72.80	0.00e+00	1258.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence