iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-049070

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01022764

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000009323.2	ENSSTOT00000009327.2	ENSSTOP00000008370.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.80e-10	39.8	13	54
E3 activity/RING/U-box	6.80e-07	29.3	9	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle fk+ p+++pCgH f+++Cl + w     ++ k  rCP Cr
   Q: 13   CSICLELFKE-PVTTPCGHNFCRSCLdETW----AVQGKPYRCPQCR 54
           ********99.*******************....99**********8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawceen 72
           ee+ C+I lel+++Pv++p+G+ + rs++ e w  +g+   cP +r+   +  +l  n++l ++++++++++
   Q: 9    EELSCSICLELFKEPVTTPCGHNFCRSCLdETWAVQGKPyRCPQCRAVSpSLPELRKNTVLCAVVDQYLQAE 80
           799**************************44566555559******98856778899999999999998875 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAELFLLAEE LSCSICLELF KEPVTTPCGH NFCRSCLDET WAVQGKPYRC PQCRAVSPSL 60
PELRKNTVLC AVVDQYLQAE LEQAPVADWT PPSPPEVPSP ATQVFCDHCL KAEAVKTCLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGTTCCTGCT GGCGGAGGAG CTGTCGTGCT CCATCTGCCT GGAGCTCTTC 60
AAGGAGCCGG TCACCACCCC GTGTGGCCAC AACTTTTGCC GATCGTGCCT GGACGAGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	62.04	0.00e+00	763.00
IUUC-Apl-004101	Anas platyrhynchos	46.19	2.00e-152	532.00
IUUC-Aca-005025	Anolis carolinensis	45.12	2.00e-78	286.00
IUUC-Bta-012735	Bos taurus	58.27	0.00e+00	699.00
IUUC-Cja-019996	Callithrix jacchus	70.30	2.00e-131	462.00
IUUC-Cfa-020466	Canis familiaris	66.16	5.00e-127	447.00
IUUC-Cpo-021737	Cavia porcellus	53.10	7.00e-179	620.00
IUUC-Csa-023217	Chlorocebus sabaeus	72.34	1.00e-136	479.00
IUUC-Cho-024346	Choloepus hoffmanni	48.99	1.00e-66	246.00
IUUC-Dre-028336	Danio rerio	32.73	4.00e-72	265.00
IUUC-Dno-030082	Dasypus novemcinctus	63.92	3.00e-138	485.00
IUUC-Dor-030335	Dipodomys ordii	49.38	8.00e-69	254.00
IUUC-Ete-032923	Echinops telfairi	59.06	0.00e+00	652.00
IUUC-Eca-033411	Equus caballus	64.49	0.00e+00	800.00
IUUC-Eeu-034656	Erinaceus europaeus	62.69	1.00e-131	463.00
IUUC-Fca-035371	Felis catus	66.48	8.00e-133	467.00
IUUC-Fal-037008	Ficedula albicollis	43.41	3.00e-144	504.00
IUUC-Gmo-038668	Gadus morhua	35.11	1.00e-100	360.00
IUUC-Gga-040608	Gallus gallus	55.80	4.00e-76	278.00
IUUC-Ggo-044518	Gorilla gorilla	72.56	7.00e-136	477.00
IUUC-Hsa-045828	Homo sapiens	65.56	0.00e+00	814.00
IUUC-Lch-050478	Latimeria chalumnae	43.13	4.00e-65	242.00
IUUC-Laf-054325	Loxodonta africana	67.99	5.00e-137	480.00
IUUC-Mcc-054920	Macaca mulatta	72.34	1.00e-136	480.00
IUUC-Meu-056367	Macropus eugenii	71.18	1.00e-73	270.00
IUUC-Mga-059975	Meleagris gallopavo	42.00	1.00e-122	433.00
IUUC-Mmr-060748	Microcebus murinus	58.45	0.00e+00	693.00
IUUC-Mdo-062904	Monodelphis domestica	48.75	4.00e-165	574.00
IUUC-Mmu-063891	Mus musculus	62.48	0.00e+00	783.00
IUUC-Mpu-066473	Mustela putorius furo	70.69	5.00e-135	474.00
IUUC-Mlu-068185	Myotis lucifugus	70.82	1.00e-135	476.00
IUUC-Nle-070177	Nomascus leucogenys	71.73	2.00e-135	476.00
IUUC-Opr-070558	Ochotona princeps	61.45	3.00e-120	424.00
IUUC-Ont-072066	Oreochromis niloticus	29.33	2.00e-67	249.00
IUUC-Ocu-074461	Oryctolagus cuniculus	59.75	2.00e-128	452.00
IUUC-Ola-086736	Oryzias latipes	36.51	5.00e-87	314.00
IUUC-Oga-088937	Otolemur garnettii	63.54	0.00e+00	775.00
IUUC-Oar-089781	Ovis aries	82.51	2.00e-96	345.00
IUUC-Ptr-090771	Pan troglodytes	67.67	7.00e-138	484.00
IUUC-Pan-092830	Papio anubis	72.64	3.00e-137	481.00
IUUC-Psi-093664	Pelodiscus sinensis	50.31	2.00e-82	299.00
IUUC-Pfo-096730	Poecilia formosa	29.48	1.00e-67	250.00
IUUC-Pab-097588	Pongo abelii	65.77	2.00e-135	476.00
IUUC-Pca-100890	Procavia capensis	69.60	1.00e-126	446.00
IUUC-Pva-102314	Pteropus vampyrus	59.08	0.00e+00	687.00
IUUC-Rno-105234	Rattus norvegicus	72.56	5.00e-140	491.00
IUUC-Sce-106362	Saccharomyces cerevisiae	42.86	4.00e-10	58.90
IUUC-Sha-106807	Sarcophilus harrisii	49.23	3.00e-89	322.00
IUUC-Sar-113283	Sorex araneus	60.18	8.00e-104	370.00
IUUC-Ssc-115878	Sus scrofa	74.68	3.00e-95	340.00
IUUC-Tgu-117026	Taeniopygia guttata	40.35	7.00e-95	340.00
IUUC-Tni-120557	Tetraodon nigroviridis	28.94	5.00e-61	228.00
IUUC-Tbe-127580	Tupaia belangeri	62.57	3.00e-120	424.00
IUUC-Ttr-128648	Tursiops truncatus	82.51	3.00e-95	342.00
IUUC-Vpa-130254	Vicugna pacos	83.82	5.00e-90	324.00
IUUC-Xtr-132892	Xenopus tropicalis	42.41	9.00e-66	243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence