iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115343

UUCD1 version

UUC-SuS-00018

Ensembl Protein ID

ENSSSCP00000005249.1

UniProt Accession

C9DRN1; C9DRN1_PIG

Genbank Protein ID

ACV65522.1; ADR66820.1

Protein Name

Suppressor of cytokine signaling 6

Genbank Nucleotide ID

CU062492; HM135392

Gene Name

SOCS6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000004878.1	ENSSSCT00000005384.1	ENSSSCP00000005249.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.90e-17	62.1	488	535

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 488  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 535
           5788999********************888...***************997 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MKKISLKTFR KSFNLSKSKE ETDFMVVQQP SLAGDFGKED SLFGSCYGKD MASCDINSED 60
EKGGKNRSKS ESLMGTLKRR LSAKQKQKGK GGGPSGGSAD EDTFSSASAP LVFKDVRAQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAAAA TCAGTCTTAA AACCTTCCGG AAATCTTTCA ACCTGAGTAA AAGTAAAGAA 60
GAAACGGATT TCATGGTAGT ACAACAGCCA TCTCTAGCCG GTGACTTCGG AAAAGAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

ssc:100155619

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	93.08	0.00e+00	927.00
IUUC-Atr-002940	Amborella trichopoda	29.73	4.20e-02	32.00
IUUC-Apl-004035	Anas platyrhynchos	87.66	0.00e+00	853.00
IUUC-Aca-004782	Anolis carolinensis	86.19	0.00e+00	838.00
IUUC-Ame-011790	Astyanax mexicanus	68.50	0.00e+00	634.00
IUUC-Bta-012579	Bos taurus	96.14	3.00e-109	388.00
IUUC-Bol-015843	Brassica oleracea	28.77	2.50e-02	33.10
IUUC-Cel-018643	Caenorhabditis elegans	33.59	1.00e-11	62.80
IUUC-Cja-019528	Callithrix jacchus	92.34	0.00e+00	956.00
IUUC-Cfa-020678	Canis familiaris	93.27	0.00e+00	934.00
IUUC-Cpo-021947	Cavia porcellus	91.96	0.00e+00	946.00
IUUC-Csa-023935	Chlorocebus sabaeus	92.90	0.00e+00	931.00
IUUC-Cho-024477	Choloepus hoffmanni	89.53	0.00e+00	919.00
IUUC-Cin-025413	Ciona intestinalis	68.24	3.00e-66	245.00
IUUC-Csv-026247	Ciona savignyi	67.47	7.00e-65	240.00
IUUC-Cne-026906	Cryptococcus neoformans	23.96	2.40e-01	30.40
IUUC-Dre-027636	Danio rerio	68.89	0.00e+00	630.00
IUUC-Dno-029048	Dasypus novemcinctus	91.21	0.00e+00	913.00
IUUC-Dor-030401	Dipodomys ordii	89.18	0.00e+00	895.00
IUUC-Ete-033116	Echinops telfairi	52.65	1.00e-59	223.00
IUUC-Eca-033825	Equus caballus	93.27	0.00e+00	906.00
IUUC-Fca-036253	Felis catus	91.59	0.00e+00	850.00
IUUC-Fal-037614	Ficedula albicollis	87.66	0.00e+00	852.00
IUUC-Fox-037898	Fusarium oxysporum	27.16	1.10e-02	33.50
IUUC-Gmo-038928	Gadus morhua	69.74	0.00e+00	654.00
IUUC-Gga-040177	Gallus gallus	87.48	0.00e+00	848.00
IUUC-Gac-042263	Gasterosteus aculeatus	69.00	0.00e+00	671.00
IUUC-Ggo-045288	Gorilla gorilla	91.96	0.00e+00	926.00
IUUC-Hsa-046409	Homo sapiens	92.34	0.00e+00	927.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	91.96	0.00e+00	908.00
IUUC-Lch-050354	Latimeria chalumnae	82.28	0.00e+00	836.00
IUUC-Loc-052319	Lepisosteus oculatus	81.16	0.00e+00	796.00
IUUC-Laf-054070	Loxodonta africana	91.03	0.00e+00	874.00
IUUC-Mcc-055045	Macaca mulatta	92.71	0.00e+00	930.00
IUUC-Meu-055917	Macropus eugenii	88.22	0.00e+00	911.00
IUUC-Mga-059273	Meleagris gallopavo	87.48	0.00e+00	846.00
IUUC-Mmr-061597	Microcebus murinus	92.52	0.00e+00	930.00
IUUC-Mdo-062492	Monodelphis domestica	62.39	1.00e-106	379.00
IUUC-Mmu-063374	Mus musculus	84.39	0.00e+00	833.00
IUUC-Mpu-065967	Mustela putorius furo	90.09	0.00e+00	899.00
IUUC-Mlu-067532	Myotis lucifugus	93.46	0.00e+00	934.00
IUUC-Nle-069373	Nomascus leucogenys	92.71	0.00e+00	929.00
IUUC-Opr-070873	Ochotona princeps	88.60	0.00e+00	936.00
IUUC-Ont-072498	Oreochromis niloticus	69.37	0.00e+00	702.00
IUUC-Oan-072943	Ornithorhynchus anatinus	73.06	2.00e-97	348.00
IUUC-Ocu-073870	Oryctolagus cuniculus	92.52	0.00e+00	919.00
IUUC-Ola-086866	Oryzias latipes	90.23	5.00e-105	372.00
IUUC-Oga-089057	Otolemur garnettii	91.96	0.00e+00	917.00
IUUC-Oar-089841	Ovis aries	61.94	5.00e-164	570.00
IUUC-Ptr-091054	Pan troglodytes	92.71	0.00e+00	931.00
IUUC-Pma-094253	Petromyzon marinus	82.11	4.00e-92	331.00
IUUC-Pfo-097179	Poecilia formosa	65.01	5.00e-174	603.00
IUUC-Pab-097702	Pongo abelii	92.71	0.00e+00	929.00
IUUC-Pca-100671	Procavia capensis	83.22	2.00e-117	415.00
IUUC-Rno-106044	Rattus norvegicus	81.88	0.00e+00	825.00
IUUC-Sha-107139	Sarcophilus harrisii	87.55	0.00e+00	832.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	3.00e-02	32.00
IUUC-Sly-111748	Solanum lycopersicum	44.44	3.50e-01	29.30
IUUC-Tgu-117061	Taeniopygia guttata	87.48	0.00e+00	852.00
IUUC-Tni-119829	Tetraodon nigroviridis	67.22	0.00e+00	638.00
IUUC-Tae-123723	Triticum aestivum	28.75	3.10e-02	33.90
IUUC-Ttr-129148	Tursiops truncatus	95.33	0.00e+00	926.00
IUUC-Vpa-130780	Vicugna pacos	93.46	0.00e+00	892.00
IUUC-Vvi-130966	Vitis vinifera	32.69	5.40e-02	31.20
IUUC-Xtr-132513	Xenopus tropicalis	80.75	0.00e+00	835.00
IUUC-Xma-133904	Xiphophorus maculatus	68.69	0.00e+00	660.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence