iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000017879.2	ENSXETT00000038759.2	ENSXETP00000038759.2
ENSXETG00000017879.2	ENSXETT00000050030.3	ENSXETP00000050030.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-128	429.6	396	729

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 396  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 483
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l dle++dpe+    +   +  ++++ee++l+l f ++ eilge+++++Lk+gGeni+Vt+eNkee+++l+++
   Q: 484  GFTLPFYKRMLNKKPTLRDLESIDPEFTTLFNLYYR--DNNLEECELELYFVQDMEILGEVTSHKLKEGGENIRVTEENKEEFISLLTD 570
           ***************************998666553..46************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gf+ev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s+++qwFw+v++e+++e+r ++LqFv
   Q: 571  WRFTRGVEEQTNAFLDGFKEVVPLEWLRYFDEKELELMLCGMQEIDIADWQKNTIYRH-YTKNSKQVQWFWQVVKEMDNEKRIRLLQFV 658
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i + ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 659  TGTCRLPVGGFVELIgsngPQKFCIDRVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 729
           *********************************************************************96 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MASSGSNQTS DGFTQEKLQL SVKENSVPLQ INLQAAHKAS GDDLTIALDE HMEAVEDADS 60
EMVFENGHYA LEKISSPPQS ASSDSSQPIK NQDNTSNITV LVNGESSHAT SSELDVPAQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCTGAAGG CGGAAGTGAA GAAGAGAGTG GTGTAGCAGG TAAATACAAA TAAAAGAATT 60
TGGCGGAACA GCATAGGGTC GGCGACAGTA AAACAGATTT GATTTGGAAG AGTGGGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	89.21	0.00e+00	1116.00
IUUC-Apl-003912	Anas platyrhynchos	86.06	0.00e+00	1052.00
IUUC-Aca-004291	Anolis carolinensis	88.44	0.00e+00	1137.00
IUUC-Bta-013231	Bos taurus	91.02	0.00e+00	1118.00
IUUC-Cel-018299	Caenorhabditis elegans	65.86	0.00e+00	801.00
IUUC-Cja-019455	Callithrix jacchus	90.49	0.00e+00	1106.00
IUUC-Cfa-021017	Canis familiaris	91.20	0.00e+00	1116.00
IUUC-Cpo-021988	Cavia porcellus	82.75	0.00e+00	1130.00
IUUC-Csa-023549	Chlorocebus sabaeus	80.24	0.00e+00	1113.00
IUUC-Cin-025212	Ciona intestinalis	69.43	0.00e+00	837.00
IUUC-Csv-026256	Ciona savignyi	68.74	0.00e+00	831.00
IUUC-Dre-028513	Danio rerio	88.46	0.00e+00	1097.00
IUUC-Dno-028976	Dasypus novemcinctus	80.87	0.00e+00	1115.00
IUUC-Dor-030176	Dipodomys ordii	91.02	0.00e+00	1107.00
IUUC-Dme-032041	Drosophila melanogaster	67.16	0.00e+00	834.00
IUUC-Eca-033949	Equus caballus	90.85	0.00e+00	1116.00
IUUC-Eeu-034529	Erinaceus europaeus	78.86	0.00e+00	946.00
IUUC-Fca-036236	Felis catus	81.69	0.00e+00	1132.00
IUUC-Fal-036948	Ficedula albicollis	90.40	0.00e+00	1113.00
IUUC-Gmo-038842	Gadus morhua	87.15	0.00e+00	1040.00
IUUC-Gga-040617	Gallus gallus	87.35	0.00e+00	1126.00
IUUC-Gac-041338	Gasterosteus aculeatus	83.39	0.00e+00	1053.00
IUUC-Ggo-045278	Gorilla gorilla	91.02	0.00e+00	1117.00
IUUC-Hsa-046148	Homo sapiens	91.02	0.00e+00	1117.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	90.69	0.00e+00	1040.00
IUUC-Lch-050663	Latimeria chalumnae	89.00	0.00e+00	1121.00
IUUC-Loc-052604	Lepisosteus oculatus	81.75	0.00e+00	1085.00
IUUC-Laf-053944	Loxodonta africana	81.34	0.00e+00	1121.00
IUUC-Mcc-055655	Macaca mulatta	90.49	0.00e+00	1113.00
IUUC-Meu-055953	Macropus eugenii	78.69	0.00e+00	966.00
IUUC-Mga-060190	Meleagris gallopavo	86.82	0.00e+00	1130.00
IUUC-Mmr-060896	Microcebus murinus	81.58	0.00e+00	1119.00
IUUC-Mdo-062536	Monodelphis domestica	82.72	0.00e+00	1135.00
IUUC-Mmu-064017	Mus musculus	91.20	0.00e+00	1119.00
IUUC-Mpu-066608	Mustela putorius furo	79.97	0.00e+00	1089.00
IUUC-Mlu-067623	Myotis lucifugus	80.55	0.00e+00	1093.00
IUUC-Nle-069496	Nomascus leucogenys	70.66	0.00e+00	1076.00
IUUC-Opr-071054	Ochotona princeps	89.79	0.00e+00	1095.00
IUUC-Ont-071279	Oreochromis niloticus	85.33	0.00e+00	1064.00
IUUC-Oan-073512	Ornithorhynchus anatinus	78.43	0.00e+00	1088.00
IUUC-Ocu-074271	Oryctolagus cuniculus	81.87	0.00e+00	1109.00
IUUC-Ola-087237	Oryzias latipes	84.01	0.00e+00	1015.00
IUUC-Oga-088164	Otolemur garnettii	82.70	0.00e+00	1129.00
IUUC-Oar-089698	Ovis aries	91.02	0.00e+00	1117.00
IUUC-Ptr-091306	Pan troglodytes	89.61	0.00e+00	1092.00
IUUC-Pan-092814	Papio anubis	89.08	0.00e+00	1090.00
IUUC-Pma-094279	Petromyzon marinus	64.98	0.00e+00	773.00
IUUC-Pfo-096709	Poecilia formosa	88.00	0.00e+00	1058.00
IUUC-Pab-098494	Pongo abelii	90.65	0.00e+00	1110.00
IUUC-Pca-100596	Procavia capensis	80.03	0.00e+00	975.00
IUUC-Pva-103154	Pteropus vampyrus	81.49	0.00e+00	1070.00
IUUC-Rno-104954	Rattus norvegicus	90.85	0.00e+00	1110.00
IUUC-Sha-106781	Sarcophilus harrisii	82.15	0.00e+00	1150.00
IUUC-Ssc-116307	Sus scrofa	77.33	0.00e+00	1071.00
IUUC-Tgu-116530	Taeniopygia guttata	84.68	0.00e+00	1008.00
IUUC-Tru-118287	Takifugu rubripes	87.19	0.00e+00	1037.00
IUUC-Tni-120801	Tetraodon nigroviridis	87.80	0.00e+00	1047.00
IUUC-Tbe-127793	Tupaia belangeri	73.30	0.00e+00	962.00
IUUC-Ttr-128275	Tursiops truncatus	91.02	0.00e+00	1115.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence