iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066339

Ensembl Protein ID

ENSMPUP00000001030.1

UniProt Accession

M3XPN0; M3XPN0_MUSPF

Genbank Protein ID

ENSMPUP00000001030

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AEYP01043027

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000001038.1	ENSMPUT00000001051.1	ENSMPUP00000001030.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-91	307.4	194	822

Active Site

Position(s)	Description	Evidence
203	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
758	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 273
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 274  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEQQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 362
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 363  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkeseeekdndsyikersdipsgtskhlqkkakkqakkqakn 451
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  qrrqqkiqgkvlhlndictidhpednecevemslqgevdvksnhiseeeiihkeycvnqkdvngqekmvesvtdnqksteevdmnsvhm 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  dndldvlasspgdctrnvngayltegsgdvdissgfknlnlntvlqpdeinieilneshspgtkvyevvnedpetafctlanreafhtd 629
           ***************************************************************************************** PP
   S: 186  ..slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
             s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+v+f
   Q: 630  ecSIQHCLYQFTRNEKLRDANKLLCEVCTRRQFsgpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHVKF 716
           *****************************666677777777777777777*********************..9999************ PP
   S: 256  pleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtev 317
           p+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++v
   Q: 717  PEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKAraanshlsnlvlhgdipqdfemqsTKGQWFHISDTHVQAV 805
           ************9999887777999************************9999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 806  PTTKVLN---SQAYLLFYER 822
           *******...********98 PP

Organism

Mustela putorius furo

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPMCRHIRKG LEQGNLKRAL LNVEWNICQD CKTDNKIKDK 60
SEEETEENPS VWLCLKCGHQ GCGRDSQEQH ALKHYMTPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGTTATTT TGTGTCAGTA AGTAATCCAT AAAGTGCCAA CATGGGAAAG AAACGGACAA 60
AGGGAAAAAC TGTTCCAATT GATGATTCTT CTGAATCTTT AGGTATATTT TACCAATTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	36.28	8.00e-29	122.00
IUUC-Aml-001931	Ailuropoda melanoleuca	96.61	0.00e+00	1492.00
IUUC-Atr-003015	Amborella trichopoda	32.45	2.00e-36	148.00
IUUC-Apl-004145	Anas platyrhynchos	60.92	0.00e+00	897.00
IUUC-Aca-004314	Anolis carolinensis	59.06	0.00e+00	889.00
IUUC-Aly-006422	Arabidopsis lyrata	28.62	7.00e-29	122.00
IUUC-Ath-006732	Arabidopsis thaliana	33.53	1.00e-32	135.00
IUUC-Ame-011659	Astyanax mexicanus	49.32	1.00e-110	394.00
IUUC-Bta-013362	Bos taurus	88.50	0.00e+00	1420.00
IUUC-Bdi-014624	Brachypodium distachyon	30.96	5.00e-28	120.00
IUUC-Bol-015941	Brassica oleracea	29.90	3.00e-32	134.00
IUUC-Bra-016751	Brassica rapa	29.26	4.00e-30	127.00
IUUC-Cja-019177	Callithrix jacchus	89.36	0.00e+00	1458.00
IUUC-Cfa-020051	Canis familiaris	96.61	0.00e+00	1503.00
IUUC-Cpo-021886	Cavia porcellus	81.81	0.00e+00	1305.00
IUUC-Csa-024103	Chlorocebus sabaeus	89.72	0.00e+00	1471.00
IUUC-Cho-024315	Choloepus hoffmanni	75.61	2.00e-127	449.00
IUUC-Cin-025775	Ciona intestinalis	50.35	4.00e-40	156.00
IUUC-Csv-026075	Ciona savignyi	51.43	3.00e-58	219.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	6.00e-20	92.40
IUUC-Dre-028388	Danio rerio	45.76	0.00e+00	645.00
IUUC-Dno-029409	Dasypus novemcinctus	87.88	0.00e+00	1406.00
IUUC-Dor-030443	Dipodomys ordii	78.76	0.00e+00	651.00
IUUC-Ete-032807	Echinops telfairi	84.69	0.00e+00	690.00
IUUC-Eca-033479	Equus caballus	90.19	0.00e+00	1474.00
IUUC-Eeu-034835	Erinaceus europaeus	84.10	0.00e+00	674.00
IUUC-Fca-036320	Felis catus	95.76	0.00e+00	1529.00
IUUC-Fal-037029	Ficedula albicollis	59.34	0.00e+00	843.00
IUUC-Gmo-039480	Gadus morhua	52.48	1.00e-114	407.00
IUUC-Gga-040527	Gallus gallus	63.01	0.00e+00	909.00
IUUC-Gac-042343	Gasterosteus aculeatus	50.34	4.00e-112	399.00
IUUC-Gma-044402	Glycine max	29.34	2.00e-32	134.00
IUUC-Ggo-045598	Gorilla gorilla	89.72	0.00e+00	1461.00
IUUC-Hsa-046598	Homo sapiens	89.36	0.00e+00	1452.00
IUUC-Hvu-047146	Hordeum vulgare	31.08	1.00e-28	122.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	90.57	0.00e+00	1445.00
IUUC-Lch-050536	Latimeria chalumnae	56.43	4.00e-127	448.00
IUUC-Lpe-050703	Leersia perrieri	37.95	5.00e-28	120.00
IUUC-Loc-051814	Lepisosteus oculatus	57.25	5.00e-128	451.00
IUUC-Laf-053732	Loxodonta africana	86.99	0.00e+00	1418.00
IUUC-Mcc-054661	Macaca mulatta	90.08	0.00e+00	1474.00
IUUC-Meu-055967	Macropus eugenii	74.49	3.00e-158	552.00
IUUC-Mtr-057945	Medicago truncatula	31.61	4.00e-33	137.00
IUUC-Mga-059551	Meleagris gallopavo	62.25	0.00e+00	917.00
IUUC-Mvi-060391	Microbotryum violaceum	33.16	1.00e-19	92.00
IUUC-Mmr-061747	Microcebus murinus	89.95	0.00e+00	1435.00
IUUC-Mdo-062220	Monodelphis domestica	69.41	0.00e+00	1048.00
IUUC-Mmu-063582	Mus musculus	81.18	0.00e+00	1244.00
IUUC-Mac-064941	Musa acuminata	33.04	2.00e-37	150.00
IUUC-Mlu-067511	Myotis lucifugus	85.61	0.00e+00	1341.00
IUUC-Nle-069252	Nomascus leucogenys	90.21	0.00e+00	1477.00
IUUC-Opr-070969	Ochotona princeps	83.98	0.00e+00	1308.00
IUUC-Ont-071786	Oreochromis niloticus	50.47	5.00e-115	408.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.61	0.00e+00	1409.00
IUUC-Oba-075094	Oryza barthii	30.67	2.00e-30	128.00
IUUC-Obr-076743	Oryza brachyantha	31.37	5.00e-30	126.00
IUUC-Ogl-077739	Oryza glaberrima	30.67	2.00e-30	127.00
IUUC-Ogu-078851	Oryza glumaepatula	30.67	2.00e-30	127.00
IUUC-Oin-079402	Oryza indica	30.67	2.00e-30	127.00
IUUC-Olo-080431	Oryza longistaminata	30.67	2.00e-30	128.00
IUUC-Ome-081580	Oryza meridionalis	30.67	3.00e-30	127.00
IUUC-Oni-082644	Oryza nivara	30.67	2.00e-30	127.00
IUUC-Opu-083452	Oryza punctata	30.43	2.00e-30	127.00
IUUC-Oru-084546	Oryza rufipogon	30.67	2.00e-30	127.00
IUUC-Osa-085858	Oryza sativa	30.67	2.00e-30	128.00
IUUC-Oga-088713	Otolemur garnettii	89.60	0.00e+00	1430.00
IUUC-Oar-089887	Ovis aries	89.12	0.00e+00	1431.00
IUUC-Ptr-091670	Pan troglodytes	89.84	0.00e+00	1467.00
IUUC-Pan-092293	Papio anubis	90.08	0.00e+00	1474.00
IUUC-Psi-093101	Pelodiscus sinensis	64.72	0.00e+00	932.00
IUUC-Ppa-095622	Physcomitrella patens	31.29	9.00e-33	135.00
IUUC-Pfo-097202	Poecilia formosa	49.89	2.00e-116	413.00
IUUC-Pab-098773	Pongo abelii	91.78	0.00e+00	1142.00
IUUC-Pop-099136	Populus trichocarpa	30.39	2.00e-40	160.00
IUUC-Pca-101069	Procavia capensis	71.22	0.00e+00	874.00
IUUC-Ppe-101794	Prunus persica	30.32	4.00e-34	140.00
IUUC-Pva-103092	Pteropus vampyrus	87.20	0.00e+00	691.00
IUUC-Rno-105237	Rattus norvegicus	82.85	0.00e+00	1273.00
IUUC-Sha-106889	Sarcophilus harrisii	72.91	0.00e+00	1114.00
IUUC-Sit-110283	Setaria italica	32.75	3.00e-30	127.00
IUUC-Sly-111487	Solanum lycopersicum	29.06	9.00e-39	155.00
IUUC-Stu-112820	Solanum tuberosum	28.72	3.00e-36	147.00
IUUC-Sar-113530	Sorex araneus	84.06	0.00e+00	1324.00
IUUC-Sbi-113785	Sorghum bicolor	40.65	2.00e-25	111.00
IUUC-Ssc-116091	Sus scrofa	90.97	0.00e+00	1414.00
IUUC-Tgu-117478	Taeniopygia guttata	59.52	0.00e+00	867.00
IUUC-Tsy-119042	Tarsius syrichta	74.92	0.00e+00	905.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.88	9.00e-178	617.00
IUUC-Tca-121701	Theobroma cacao	28.83	4.00e-37	150.00
IUUC-Tae-125351	Triticum aestivum	31.08	4.00e-27	117.00
IUUC-Tur-126788	Triticum urartu	28.62	1.00e-26	115.00
IUUC-Tbe-127309	Tupaia belangeri	75.19	0.00e+00	1124.00
IUUC-Ttr-128271	Tursiops truncatus	92.14	0.00e+00	1457.00
IUUC-Vpa-130674	Vicugna pacos	89.06	0.00e+00	1337.00
IUUC-Xtr-131869	Xenopus tropicalis	51.42	0.00e+00	793.00
IUUC-Xma-134195	Xiphophorus maculatus	53.10	7.00e-117	414.00
IUUC-Zma-135157	Zea mays	32.30	2.00e-27	117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence