iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033656

Ensembl Protein ID

ENSECAP00000016849.1

UniProt Accession

F7BRP0; F7BRP0_HORSE

Protein Name

Uncharacterized protein

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000019317.1	ENSECAT00000020523.1	ENSECAP00000016849.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-45	152.1	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP ANGGGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCAACT GTGTACTTAA AAATGGTTAA AATGGTAAAT TTTATGTTTA TTTTGCCACA 60
ATTTAAACAA AGAAATCATG GGGTATATTG TATGCTTGAG CTTCTGCTAA TACGTACTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

ecb:100049884

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	98.68	0.00e+00	761.00
IUUC-Apl-003456	Anas platyrhynchos	92.63	0.00e+00	725.00
IUUC-Aca-005105	Anolis carolinensis	91.84	0.00e+00	720.00
IUUC-Ame-010966	Astyanax mexicanus	79.43	4.00e-177	613.00
IUUC-Bta-012424	Bos taurus	89.21	0.00e+00	653.00
IUUC-Cel-018144	Caenorhabditis elegans	41.91	2.00e-76	279.00
IUUC-Cja-019898	Callithrix jacchus	98.16	0.00e+00	756.00
IUUC-Cfa-020830	Canis familiaris	98.68	0.00e+00	760.00
IUUC-Cpo-021487	Cavia porcellus	88.16	0.00e+00	655.00
IUUC-Csa-023693	Chlorocebus sabaeus	98.16	0.00e+00	756.00
IUUC-Cin-025348	Ciona intestinalis	37.76	4.00e-67	248.00
IUUC-Csv-026046	Ciona savignyi	38.90	6.00e-70	257.00
IUUC-Dre-028334	Danio rerio	81.72	0.00e+00	625.00
IUUC-Dno-028973	Dasypus novemcinctus	94.21	0.00e+00	733.00
IUUC-Dor-031003	Dipodomys ordii	95.26	0.00e+00	704.00
IUUC-Dme-031846	Drosophila melanogaster	41.99	2.00e-89	322.00
IUUC-Ete-032792	Echinops telfairi	86.20	0.00e+00	661.00
IUUC-Fca-036347	Felis catus	98.95	0.00e+00	762.00
IUUC-Fal-037095	Ficedula albicollis	92.37	0.00e+00	726.00
IUUC-Gmo-039410	Gadus morhua	71.17	1.00e-161	562.00
IUUC-Gga-040155	Gallus gallus	92.63	0.00e+00	725.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.10	1.00e-166	578.00
IUUC-Ggo-044805	Gorilla gorilla	98.42	0.00e+00	757.00
IUUC-Hsa-046585	Homo sapiens	98.42	0.00e+00	758.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	95.79	0.00e+00	721.00
IUUC-Lch-049795	Latimeria chalumnae	88.68	0.00e+00	696.00
IUUC-Loc-051985	Lepisosteus oculatus	88.16	0.00e+00	669.00
IUUC-Laf-054228	Loxodonta africana	95.53	0.00e+00	739.00
IUUC-Mcc-055402	Macaca mulatta	98.16	0.00e+00	756.00
IUUC-Mga-059374	Meleagris gallopavo	92.63	0.00e+00	725.00
IUUC-Mmr-061453	Microcebus murinus	97.37	0.00e+00	751.00
IUUC-Mdo-063080	Monodelphis domestica	91.58	0.00e+00	720.00
IUUC-Mmu-063529	Mus musculus	95.26	0.00e+00	720.00
IUUC-Mpu-066815	Mustela putorius furo	98.68	0.00e+00	761.00
IUUC-Mlu-067132	Myotis lucifugus	95.08	1.00e-165	575.00
IUUC-Nle-069371	Nomascus leucogenys	98.42	0.00e+00	758.00
IUUC-Opr-070948	Ochotona princeps	96.02	0.00e+00	703.00
IUUC-Ont-071410	Oreochromis niloticus	75.57	2.00e-163	568.00
IUUC-Oan-073304	Ornithorhynchus anatinus	91.50	8.00e-165	572.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.11	0.00e+00	727.00
IUUC-Ola-086808	Oryzias latipes	73.78	4.00e-161	560.00
IUUC-Oga-088391	Otolemur garnettii	97.63	0.00e+00	733.00
IUUC-Oar-090025	Ovis aries	82.63	1.00e-169	588.00
IUUC-Ptr-090975	Pan troglodytes	98.42	0.00e+00	758.00
IUUC-Pan-092287	Papio anubis	98.16	0.00e+00	756.00
IUUC-Psi-093413	Pelodiscus sinensis	92.89	0.00e+00	726.00
IUUC-Pfo-097129	Poecilia formosa	77.22	4.00e-169	587.00
IUUC-Pab-098756	Pongo abelii	98.42	0.00e+00	758.00
IUUC-Pca-100235	Procavia capensis	82.63	0.00e+00	651.00
IUUC-Pva-102294	Pteropus vampyrus	95.26	0.00e+00	723.00
IUUC-Rno-105090	Rattus norvegicus	95.00	0.00e+00	719.00
IUUC-Sha-107521	Sarcophilus harrisii	92.11	0.00e+00	723.00
IUUC-Sar-113697	Sorex araneus	89.84	0.00e+00	675.00
IUUC-Ssc-115958	Sus scrofa	88.61	3.00e-168	583.00
IUUC-Tgu-116559	Taeniopygia guttata	90.53	0.00e+00	701.00
IUUC-Tru-117677	Takifugu rubripes	76.20	2.00e-167	581.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.28	2.00e-165	575.00
IUUC-Tbe-127931	Tupaia belangeri	96.20	0.00e+00	634.00
IUUC-Ttr-128993	Tursiops truncatus	89.21	0.00e+00	657.00
IUUC-Xtr-132543	Xenopus tropicalis	84.78	0.00e+00	676.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence