iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073121

UUCD1 version

UUC-OrA-00660

Ensembl Protein ID

ENSOANP00000005790.4

UniProt Accession

F7FC33; F7FC33_ORNAN

Protein Name

Uncharacterized protein

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000003648.4	ENSOANT00000005792.4	ENSOANP00000005790.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.30e-96	321.9	1684	2063

Active Site

Position(s)	Description	Evidence
2030	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + +++  +  +                       ++  
   Q: 1684 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLTNPKGSQEG-T--KyiqnlqglfalpfgrtakpahiaKVKM 1766
           56899***********.**********************6666533333322221.1..1234558888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1767 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFNIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqcaletlsm 1853
           **********************************654444**************999999855555511555556666444444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG+++ Vt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F
   Q: 1854 ngcSVED------------LgldftLPGFPNIELKKGGKDTAVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYF 1928
           4444444............25555588999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1929 YPEELDQLLCGSktDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 2015
           ***********97778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2016 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2063
           988888***************************************985 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGTQLQDDSI GGRSHLGQAK HKAYSPPESR KSISKAPKVQ 60
SNTPSEQPRG HLSKRSCSSS TVVLVPQPEE PDKANTSDRQ KTEQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTAGCTCTT TCGAAGTGTC TAACCCGTTG TTTTTAATTT TTCAGGGAGC TGTAAACTGT 60
TGTGGGGAGA GAATTTGCAT CTCTTGCTGC CATCCTTCTC AGGAAACATT TGAAAGGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.39	3.00e-126	446.00
IUUC-Aml-001502	Ailuropoda melanoleuca	93.96	0.00e+00	3580.00
IUUC-Atr-002821	Amborella trichopoda	37.30	1.00e-117	417.00
IUUC-Apl-003531	Anas platyrhynchos	91.21	0.00e+00	3402.00
IUUC-Aly-005962	Arabidopsis lyrata	44.68	3.00e-113	403.00
IUUC-Ath-006636	Arabidopsis thaliana	44.49	1.00e-113	404.00
IUUC-Ago-007875	Ashbya gossypii	36.01	1.00e-80	295.00
IUUC-Acl-008242	Aspergillus clavatus	36.05	2.00e-112	400.00
IUUC-Afl-008736	Aspergillus flavus	38.24	2.00e-108	387.00
IUUC-Afu-008812	Aspergillus fumigatus	34.80	2.00e-112	400.00
IUUC-Ani-009407	Aspergillus nidulans	36.97	2.00e-109	390.00
IUUC-Ang-009763	Aspergillus niger	39.23	7.00e-104	372.00
IUUC-Aor-009941	Aspergillus oryzae	30.59	2.00e-111	397.00
IUUC-Ate-010459	Aspergillus terreus	37.10	2.00e-83	304.00
IUUC-Ame-011761	Astyanax mexicanus	88.65	0.00e+00	3009.00
IUUC-Bgr-012265	Blumeria graminis	35.31	2.00e-104	374.00
IUUC-Bta-013070	Bos taurus	90.38	0.00e+00	3446.00
IUUC-Bci-013890	Botrytis cinerea	39.32	1.00e-101	364.00
IUUC-Bdi-014046	Brachypodium distachyon	38.18	6.00e-123	435.00
IUUC-Bol-015942	Brassica oleracea	44.42	2.00e-114	407.00
IUUC-Bra-016849	Brassica rapa	44.42	5.00e-114	405.00
IUUC-Cja-019046	Callithrix jacchus	92.56	0.00e+00	3535.00
IUUC-Cfa-020521	Canis familiaris	92.36	0.00e+00	3445.00
IUUC-Cpo-021639	Cavia porcellus	89.91	0.00e+00	3452.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.46	7.00e-90	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	94.83	0.00e+00	3609.00
IUUC-Cho-024380	Choloepus hoffmanni	90.07	0.00e+00	2091.00
IUUC-Cin-025482	Ciona intestinalis	51.21	2.00e-159	555.00
IUUC-Csv-026121	Ciona savignyi	48.33	0.00e+00	1546.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.34	2.00e-110	393.00
IUUC-Cne-026857	Cryptococcus neoformans	39.58	7.00e-94	338.00
IUUC-Cme-027226	Cyanidioschyzon merolae	34.34	6.00e-76	279.00
IUUC-Dre-028174	Danio rerio	88.86	0.00e+00	3058.00
IUUC-Dor-030939	Dipodomys ordii	84.39	0.00e+00	1399.00
IUUC-Dse-031444	Dothistroma septosporum	38.91	3.00e-104	373.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	1.00e-174	607.00
IUUC-Ete-032345	Echinops telfairi	87.86	0.00e+00	2236.00
IUUC-Eca-033229	Equus caballus	93.42	0.00e+00	3471.00
IUUC-Eeu-035205	Erinaceus europaeus	81.19	0.00e+00	2980.00
IUUC-Fca-036444	Felis catus	93.33	0.00e+00	3533.00
IUUC-Fal-037131	Ficedula albicollis	94.72	0.00e+00	3578.00
IUUC-Fox-038035	Fusarium oxysporum	35.96	9.00e-110	390.00
IUUC-Fso-038320	Fusarium solani	35.76	6.00e-110	392.00
IUUC-Gmo-039497	Gadus morhua	80.20	0.00e+00	3043.00
IUUC-Ggr-040057	Gaeumannomyces graminis	39.29	1.00e-107	384.00
IUUC-Gga-041021	Gallus gallus	95.10	0.00e+00	3593.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.15	0.00e+00	3044.00
IUUC-Gma-043060	Glycine max	38.64	2.00e-121	430.00
IUUC-Ggo-044855	Gorilla gorilla	92.51	0.00e+00	3533.00
IUUC-Hsa-046147	Homo sapiens	90.47	0.00e+00	3431.00
IUUC-Hvu-047775	Hordeum vulgare	38.98	8.00e-125	441.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	92.80	0.00e+00	3437.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	2.00e-85	310.00
IUUC-Lch-049818	Latimeria chalumnae	85.19	0.00e+00	3115.00
IUUC-Lpe-051017	Leersia perrieri	38.18	9.00e-119	421.00
IUUC-Loc-051777	Lepisosteus oculatus	87.80	0.00e+00	3364.00
IUUC-Lma-052990	Leptosphaeria maculans	36.17	9.00e-114	405.00
IUUC-Laf-053727	Loxodonta africana	93.57	0.00e+00	3530.00
IUUC-Mcc-055799	Macaca mulatta	93.42	0.00e+00	3519.00
IUUC-Meu-056065	Macropus eugenii	94.05	0.00e+00	2098.00
IUUC-Mor-057054	Magnaporthe oryzae	34.34	3.00e-106	380.00
IUUC-Mpo-057417	Magnaporthe poae	39.17	3.00e-108	387.00
IUUC-Mtr-057849	Medicago truncatula	37.09	3.00e-113	403.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	2.00e-107	383.00
IUUC-Mga-059580	Meleagris gallopavo	93.16	0.00e+00	3043.00
IUUC-Mvi-060507	Microbotryum violaceum	39.82	5.00e-113	402.00
IUUC-Mmr-060816	Microcebus murinus	94.93	0.00e+00	3610.00
IUUC-Mdo-062866	Monodelphis domestica	93.86	0.00e+00	3427.00
IUUC-Mmu-063906	Mus musculus	92.55	0.00e+00	3501.00
IUUC-Mac-064675	Musa acuminata	38.65	1.00e-112	400.00
IUUC-Mpu-066199	Mustela putorius furo	93.57	0.00e+00	3508.00
IUUC-Mlu-067110	Myotis lucifugus	92.94	0.00e+00	3498.00
IUUC-Nfi-068482	Neosartorya fischeri	34.80	7.00e-112	399.00
IUUC-Ncr-068906	Neurospora crassa	39.13	3.00e-109	390.00
IUUC-Nle-069410	Nomascus leucogenys	93.23	0.00e+00	3522.00
IUUC-Opr-070401	Ochotona princeps	83.44	0.00e+00	1887.00
IUUC-Ont-072100	Oreochromis niloticus	83.60	0.00e+00	3169.00
IUUC-Ocu-074623	Oryctolagus cuniculus	93.28	0.00e+00	3534.00
IUUC-Oba-075380	Oryza barthii	37.11	2.00e-114	406.00
IUUC-Obr-076915	Oryza brachyantha	37.48	1.00e-118	421.00
IUUC-Ogl-077055	Oryza glaberrima	38.01	1.00e-118	421.00
IUUC-Ogu-078892	Oryza glumaepatula	37.15	3.00e-113	402.00
IUUC-Oin-079256	Oryza indica	37.83	1.00e-117	417.00
IUUC-Olo-080343	Oryza longistaminata	37.83	9.00e-118	418.00
IUUC-Ome-081422	Oryza meridionalis	37.55	6.00e-117	415.00
IUUC-Oni-083047	Oryza nivara	37.30	2.00e-115	410.00
IUUC-Opu-083641	Oryza punctata	36.89	2.00e-111	396.00
IUUC-Oru-084439	Oryza rufipogon	37.30	8.00e-114	404.00
IUUC-Osa-085972	Oryza sativa	37.87	6.00e-117	414.00
IUUC-Ola-087173	Oryzias latipes	81.51	0.00e+00	3101.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	9.00e-88	317.00
IUUC-Oga-087908	Otolemur garnettii	92.32	0.00e+00	3526.00
IUUC-Oar-090277	Ovis aries	91.64	0.00e+00	3531.00
IUUC-Ptr-091543	Pan troglodytes	90.52	0.00e+00	3436.00
IUUC-Pan-092243	Papio anubis	93.47	0.00e+00	3521.00
IUUC-Psi-093150	Pelodiscus sinensis	94.09	0.00e+00	3603.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.32	9.00e-114	405.00
IUUC-Ppa-095181	Physcomitrella patens	42.33	1.00e-107	383.00
IUUC-Pfo-096267	Poecilia formosa	82.96	0.00e+00	3107.00
IUUC-Pab-098072	Pongo abelii	93.52	0.00e+00	3535.00
IUUC-Pop-099190	Populus trichocarpa	37.00	3.00e-116	413.00
IUUC-Pca-100311	Procavia capensis	87.16	0.00e+00	3178.00
IUUC-Ppe-101284	Prunus persica	37.72	6.00e-117	416.00
IUUC-Pva-102215	Pteropus vampyrus	90.49	0.00e+00	1312.00
IUUC-Pgr-103694	Puccinia graminis	40.64	1.00e-104	375.00
IUUC-Ptt-103916	Puccinia triticina	39.64	4.00e-98	353.00
IUUC-Pte-104346	Pyrenophora teres	39.41	2.00e-109	390.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	1.00e-109	391.00
IUUC-Rno-105315	Rattus norvegicus	91.88	0.00e+00	3489.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.81	9.00e-71	261.00
IUUC-Sha-106835	Sarcophilus harrisii	95.99	0.00e+00	3695.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.85	1.00e-95	344.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.82	5.00e-95	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.32	5.00e-104	372.00
IUUC-Smo-109590	Selaginella moellendorffii	42.91	4.00e-111	396.00
IUUC-Sit-110717	Setaria italica	37.68	6.00e-120	425.00
IUUC-Sly-111469	Solanum lycopersicum	39.08	1.00e-121	431.00
IUUC-Stu-112896	Solanum tuberosum	38.22	4.00e-105	375.00
IUUC-Sar-113224	Sorex araneus	82.68	0.00e+00	1835.00
IUUC-Sbi-114313	Sorghum bicolor	37.88	9.00e-123	435.00
IUUC-Sre-114993	Sporisorium reilianum	33.67	1.00e-100	361.00
IUUC-Ssc-115535	Sus scrofa	89.11	0.00e+00	3366.00
IUUC-Tgu-117493	Taeniopygia guttata	92.87	0.00e+00	2772.00
IUUC-Tru-118669	Takifugu rubripes	81.31	0.00e+00	3047.00
IUUC-Tsy-119373	Tarsius syrichta	90.94	0.00e+00	1806.00
IUUC-Tni-120049	Tetraodon nigroviridis	78.17	0.00e+00	870.00
IUUC-Tca-121779	Theobroma cacao	38.47	8.00e-115	408.00
IUUC-Tre-122195	Trichoderma reesei	35.95	5.00e-106	379.00
IUUC-Tvi-122650	Trichoderma virens	35.63	2.00e-108	387.00
IUUC-Tae-123580	Triticum aestivum	38.29	2.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.25	4.00e-125	442.00
IUUC-Tme-126964	Tuber melanosporum	40.08	1.00e-104	375.00
IUUC-Tbe-128149	Tupaia belangeri	82.93	0.00e+00	1229.00
IUUC-Ttr-128165	Tursiops truncatus	92.17	0.00e+00	2977.00
IUUC-Uma-129365	Ustilago maydis	35.71	3.00e-88	320.00
IUUC-Vda-129725	Verticillium dahliae	40.88	3.00e-108	386.00
IUUC-Vpa-130678	Vicugna pacos	93.88	0.00e+00	2607.00
IUUC-Vvi-131147	Vitis vinifera	38.52	2.00e-120	427.00
IUUC-Xtr-132636	Xenopus tropicalis	87.06	0.00e+00	3268.00
IUUC-Xma-133458	Xiphophorus maculatus	83.11	0.00e+00	3148.00
IUUC-Yli-134481	Yarrowia lipolytica	39.12	8.00e-96	345.00
IUUC-Zma-135657	Zea mays	38.65	5.00e-121	429.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence