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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046317
UUCD1 version UUC-HoS-00488
Ensembl Protein ID ENSP00000382330.1
UniProt Accession A6NCQ9; RN222_HUMAN
Genbank Protein ID ENSP00000343799
Protein Name RING finger protein 222
Genbank Nucleotide ID AC026130
Gene Name RNF222
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000189051.5 ENST00000399398.2 ENSP00000382330.1
Annotation
Cancer Mutation
ICGCCOSMICCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexInWeb_IM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.10e-09 38.5 14 65
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkw.....pglknssskefrCPlCr 46
           C++C+e f        ++l+CgHvf++dCl k+     ++ +   +++  CP+Cr
   Q: 14   CPVCYEKFrdleG-ASRTLSCGHVFCHDCLVKYllstrVDGQ--VQRTLVCPICR 65
           ********55532.3899************999888655555..888889****8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV 60
CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046317|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCATTAGGAA TTGCCTCGGC GGTGGCGGTC ACACTAACAG CAACAGGAGG AGATCGTGCT 60
GCTGCTCAGC ACCTCGGGGT GGCTCAGATC TGCTGGAGGC CCCAGGAGGG AAGGTGGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046317|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13445--zf-RING_UBOX
SMART

SM00184--RING
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG hsa:643904
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001331 Ailuropoda melanoleuca 79.13 4.00e-48 183.00
IUUC-Apl-003509 Anas platyrhynchos 46.88 8.00e-36 143.00
IUUC-Aca-004916 Anolis carolinensis 41.46 1.00e-22 99.80
IUUC-Bta-013443 Bos taurus 79.89 4.00e-68 250.00
IUUC-Cja-019637 Callithrix jacchus 95.17 2.00e-79 288.00
IUUC-Cfa-020737 Canis familiaris 76.11 2.00e-63 235.00
IUUC-Cpo-022224 Cavia porcellus 81.98 1.00e-63 235.00
IUUC-Csa-024175 Chlorocebus sabaeus 94.97 8.00e-89 319.00
IUUC-Dre-028060 Danio rerio 34.25 2.00e-21 95.90
IUUC-Dno-030024 Dasypus novemcinctus 85.03 6.00e-70 256.00
IUUC-Dor-030936 Dipodomys ordii 79.33 3.00e-70 258.00
IUUC-Eca-033759 Equus caballus 85.42 5.00e-79 286.00
IUUC-Fal-037142 Ficedula albicollis 41.55 8.00e-29 120.00
IUUC-Gmo-039196 Gadus morhua 37.34 5.00e-21 94.40
IUUC-Gga-041189 Gallus gallus 46.39 5.00e-34 137.00
IUUC-Gac-041497 Gasterosteus aculeatus 41.07 6.00e-23 100.00
IUUC-Ggo-045020 Gorilla gorilla 97.59 1.00e-84 305.00
IUUC-Itr-048656 Ictidomys tridecemlineatus 82.68 6.00e-75 273.00
IUUC-Lch-049885 Latimeria chalumnae 38.69 2.00e-22 99.00
IUUC-Laf-053457 Loxodonta africana 79.89 7.00e-72 263.00
IUUC-Mcc-054653 Macaca mulatta 96.20 3.00e-79 287.00
IUUC-Mga-059753 Meleagris gallopavo 47.37 2.00e-36 145.00
IUUC-Mdo-062993 Monodelphis domestica 71.95 2.00e-70 258.00
IUUC-Mmu-063225 Mus musculus 80.45 2.00e-66 245.00
IUUC-Mpu-066299 Mustela putorius furo 80.45 3.00e-65 241.00
IUUC-Mlu-066988 Myotis lucifugus 78.45 9.00e-65 239.00
IUUC-Nle-069011 Nomascus leucogenys 97.47 6.00e-81 293.00
IUUC-Opr-070258 Ochotona princeps 87.15 1.00e-73 268.00
IUUC-Ont-071886 Oreochromis niloticus 40.00 1.00e-23 102.00
IUUC-Ocu-074282 Oryctolagus cuniculus 86.59 4.00e-71 260.00
IUUC-Oga-088403 Otolemur garnettii 82.12 6.00e-75 273.00
IUUC-Oar-089665 Ovis aries 83.67 3.00e-20 89.40
IUUC-Ptr-090580 Pan troglodytes 99.40 2.00e-74 271.00
IUUC-Pan-092447 Papio anubis 96.84 8.00e-80 289.00
IUUC-Psi-093673 Pelodiscus sinensis 44.25 5.00e-38 150.00
IUUC-Pfo-096933 Poecilia formosa 34.83 1.00e-20 93.20
IUUC-Pab-097867 Pongo abelii 99.37 4.00e-70 257.00
IUUC-Pva-102146 Pteropus vampyrus 84.36 1.00e-73 268.00
IUUC-Rno-105897 Rattus norvegicus 82.68 4.00e-68 250.00
IUUC-Sha-107282 Sarcophilus harrisii 65.07 1.00e-53 202.00
IUUC-Sar-113260 Sorex araneus 83.24 6.00e-77 280.00
IUUC-Ssc-115449 Sus scrofa 79.89 3.00e-53 201.00
IUUC-Tgu-117349 Taeniopygia guttata 39.89 2.00e-27 115.00
IUUC-Vda-129777 Verticillium dahliae 34.94 2.00e-06 47.00
IUUC-Xtr-132180 Xenopus tropicalis 53.33 2.00e-23 102.00
Created Date 25-Jun-2017

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