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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045822
Ensembl Protein ID ENSP00000215567.4
UniProt Accession Q9NZ01; B2RD55; O75350; Q6IBB2; Q9BWK3; Q9Y6P0; TECR_HUMAN
Genbank Protein ID AAC39872.1; AAC39873.1; AAF32373.1; BAG37802.1; AAP35843.1; CAG33173.1; AAH00174.2; AAH02425.1; AAH05952.1; AAH07801.1; AAH13881.1
Protein Name Very-long-chain enoyl-CoA reductase; Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase
Genbank Nucleotide ID AF038958; AF038959; AF222742; AK315412; BT007179; CR456892; BC000174; BC002425; BC005952; BC007801; BC013881
Gene Name TECR; GPSN2; SC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099797.12 ENST00000598918.5 ENSP00000473033.1
ENSG00000099797.12 ENST00000601187.1 ENSP00000472957.1
ENSG00000099797.12 ENST00000598715.5 ENSP00000469263.1
ENSG00000099797.12 ENST00000215567.9 ENSP00000215567.4
ENSG00000099797.12 ENST00000598987.5 ENSP00000472504.1
ENSG00000099797.12 ENST00000598333.5 ENSP00000473129.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetTRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 41.73 5.00e-47 182.00 IUUC-Spo-108110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
 Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Protein Sequence
(Fasta)
MKHYEVEILD AKTREKLCFL DKVEPHATIA EIKNLFTKTH PQWYPARQSL RLDPKGKSLK 60
DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF IYLLFYFRVP FIYGHKYDFT 120
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Protein Fasta Sequence


>IUUC-Hsa-045822|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCAGACTCTC TCTCGAGCTT CCCTTACAGG GGGAAACAGC TTGGAAGCCA TGGGGGAGGA 60
ACTTTTTTGT CTGTCAGGGG AGAGCAAGGA AGAACCCCAA GTTTCTACCT CTCACTGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045822|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0991--Mental retardation
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001104--3-oxo-5_a-steroid_4-DH_C
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50244--S5A_REDUCTASE
Pfam

PF02544--Steroid_dh
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0016491--F:oxidoreductase activity
GO:0017099--F:very-long-chain-acyl-CoA dehydrogenase activity
GO:0030497--P:fatty acid elongation
GO:0035338--P:long-chain fatty-acyl-CoA biosynthetic process
GO:0042761--P:very long-chain fatty acid biosynthetic process
KEGG hsa:9524
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000125 Aegilops tauschii 41.24 3.00e-51 195.00
IUUC-Aml-001579 Ailuropoda melanoleuca 82.64 1.00e-169 588.00
IUUC-Atr-002693 Amborella trichopoda 36.82 9.00e-41 160.00
IUUC-Apl-004113 Anas platyrhynchos 75.41 3.00e-143 501.00
IUUC-Aca-004681 Anolis carolinensis 90.91 2.00e-171 595.00
IUUC-Aly-005795 Arabidopsis lyrata 40.47 3.00e-49 188.00
IUUC-Ath-007255 Arabidopsis thaliana 39.80 5.00e-49 187.00
IUUC-Ago-007822 Ashbya gossypii 33.19 3.00e-27 115.00
IUUC-Acl-008131 Aspergillus clavatus 35.25 1.00e-34 140.00
IUUC-Afl-008670 Aspergillus flavus 33.21 4.00e-34 138.00
IUUC-Afu-009058 Aspergillus fumigatus 37.21 9.00e-34 137.00
IUUC-Ani-009299 Aspergillus nidulans 39.41 4.00e-36 145.00
IUUC-Ang-009520 Aspergillus niger 34.65 7.00e-35 140.00
IUUC-Aor-010023 Aspergillus oryzae 38.55 1.00e-38 153.00
IUUC-Ate-010593 Aspergillus terreus 37.04 2.00e-33 135.00
IUUC-Ame-011087 Astyanax mexicanus 86.04 3.00e-165 574.00
IUUC-Bgr-012251 Blumeria graminis 33.00 1.00e-36 146.00
IUUC-Bta-013170 Bos taurus 99.03 0.00e+00 635.00
IUUC-Bci-013894 Botrytis cinerea 34.15 5.00e-42 164.00
IUUC-Bdi-015014 Brachypodium distachyon 39.93 8.00e-49 187.00
IUUC-Bol-015761 Brassica oleracea 40.67 2.00e-49 189.00
IUUC-Bra-016894 Brassica rapa 40.13 5.00e-49 188.00
IUUC-Cel-018599 Caenorhabditis elegans 53.11 8.00e-90 323.00
IUUC-Cja-019333 Callithrix jacchus 95.07 2.00e-171 594.00
IUUC-Cfa-020709 Canis familiaris 99.02 0.00e+00 633.00
IUUC-Cpo-022353 Cavia porcellus 98.38 0.00e+00 635.00
IUUC-Cre-023020 Chlamydomonas reinhardtii 40.00 3.00e-50 192.00
IUUC-Csa-023716 Chlorocebus sabaeus 99.68 0.00e+00 640.00
IUUC-Csv-025915 Ciona savignyi 62.83 1.00e-114 405.00
IUUC-Cgl-026580 Colletotrichum gloeosporioides 35.82 5.00e-41 161.00
IUUC-Cne-027086 Cryptococcus neoformans 30.19 3.00e-24 105.00
IUUC-Cme-027185 Cyanidioschyzon merolae 43.10 2.00e-57 215.00
IUUC-Dre-028710 Danio rerio 85.39 2.00e-164 571.00
IUUC-Dno-029631 Dasypus novemcinctus 51.90 2.00e-86 312.00
IUUC-Dor-030220 Dipodomys ordii 98.70 0.00e+00 636.00
IUUC-Dse-031218 Dothistroma septosporum 37.63 2.00e-44 172.00
IUUC-Dme-031792 Drosophila melanogaster 53.44 1.00e-88 319.00
IUUC-Ete-032441 Echinops telfairi 87.70 9.00e-94 336.00
IUUC-Eca-033372 Equus caballus 98.70 0.00e+00 635.00
IUUC-Eeu-035351 Erinaceus europaeus 51.17 2.00e-65 242.00
IUUC-Fca-035630 Felis catus 99.67 0.00e+00 634.00
IUUC-Fal-037646 Ficedula albicollis 73.79 2.00e-112 398.00
IUUC-Fox-037721 Fusarium oxysporum 35.62 4.00e-39 155.00
IUUC-Fso-038379 Fusarium solani 33.79 3.00e-40 158.00
IUUC-Gmo-039616 Gadus morhua 73.53 1.00e-133 469.00
IUUC-Ggr-039727 Gaeumannomyces graminis 29.55 2.00e-30 126.00
IUUC-Gga-040786 Gallus gallus 71.53 2.00e-118 418.00
IUUC-Gac-041971 Gasterosteus aculeatus 79.55 1.00e-150 525.00
IUUC-Gma-043815 Glycine max 38.10 3.00e-42 165.00
IUUC-Ggo-045138 Gorilla gorilla 84.82 6.00e-144 503.00
IUUC-Hvu-047496 Hordeum vulgare 40.40 3.00e-51 195.00
IUUC-Itr-048022 Ictidomys tridecemlineatus 97.79 1.00e-159 555.00
IUUC-Kpa-049334 Komagataella pastoris 37.50 5.00e-32 131.00
IUUC-Lch-050175 Latimeria chalumnae 73.77 2.00e-142 498.00
IUUC-Lpe-051290 Leersia perrieri 39.64 1.00e-49 190.00
IUUC-Loc-052055 Lepisosteus oculatus 86.69 1.00e-165 575.00
IUUC-Lma-053284 Leptosphaeria maculans 38.30 2.00e-38 152.00
IUUC-Laf-053677 Loxodonta africana 98.03 0.00e+00 625.00
IUUC-Mcc-055371 Macaca mulatta 94.08 8.00e-169 585.00
IUUC-Meu-056786 Macropus eugenii 83.77 1.00e-151 528.00
IUUC-Mor-057062 Magnaporthe oryzae 30.23 1.00e-29 123.00
IUUC-Mpo-057319 Magnaporthe poae 28.90 7.00e-30 124.00
IUUC-Mtr-058159 Medicago truncatula 38.41 1.00e-42 167.00
IUUC-Mla-058998 Melampsora laricipopulina 34.78 2.00e-38 152.00
IUUC-Mga-059715 Meleagris gallopavo 75.41 1.00e-143 502.00
IUUC-Mvi-060498 Microbotryum violaceum 45.20 2.00e-44 173.00
IUUC-Mmr-061604 Microcebus murinus 98.05 0.00e+00 632.00
IUUC-Mdo-062723 Monodelphis domestica 95.08 2.00e-176 611.00
IUUC-Mmu-064423 Mus musculus 91.56 2.00e-167 580.00
IUUC-Mac-064557 Musa acuminata 35.74 5.00e-43 167.00
IUUC-Mpu-065790 Mustela putorius furo 99.68 0.00e+00 640.00
IUUC-Mlu-067323 Myotis lucifugus 98.69 0.00e+00 629.00
IUUC-Nfi-068303 Neosartorya fischeri 37.60 2.00e-34 139.00
IUUC-Ncr-068930 Neurospora crassa 33.58 6.00e-34 137.00
IUUC-Nle-069641 Nomascus leucogenys 99.68 0.00e+00 640.00
IUUC-Opr-070264 Ochotona princeps 50.00 5.00e-52 197.00
IUUC-Ont-072619 Oreochromis niloticus 85.71 5.00e-164 570.00
IUUC-Oan-072871 Ornithorhynchus anatinus 94.48 1.00e-177 615.00
IUUC-Ocu-074116 Oryctolagus cuniculus 51.31 5.00e-91 327.00
IUUC-Oba-075519 Oryza barthii 39.00 2.00e-50 192.00
IUUC-Obr-076026 Oryza brachyantha 39.60 5.00e-51 194.00
IUUC-Ogl-077299 Oryza glaberrima 39.39 9.00e-51 193.00
IUUC-Ogu-078328 Oryza glumaepatula 40.15 1.00e-50 192.00
IUUC-Oin-079058 Oryza indica 39.39 9.00e-51 193.00
IUUC-Olo-080760 Oryza longistaminata 39.76 1.00e-45 176.00
IUUC-Ome-081290 Oryza meridionalis 39.00 2.00e-50 192.00
IUUC-Oni-082116 Oryza nivara 39.53 9.00e-50 190.00
IUUC-Opu-083484 Oryza punctata 40.15 8.00e-50 190.00
IUUC-Oru-085234 Oryza rufipogon 39.53 9.00e-50 190.00
IUUC-Osa-085723 Oryza sativa 39.39 9.00e-51 193.00
IUUC-Ola-087142 Oryzias latipes 86.04 2.00e-164 571.00
IUUC-Olu-087663 Ostreococcus lucimarinus 37.46 4.00e-51 194.00
IUUC-Oga-088511 Otolemur garnettii 99.02 0.00e+00 630.00
IUUC-Oar-090337 Ovis aries 73.86 2.00e-121 428.00
IUUC-Ptr-090829 Pan troglodytes 99.67 0.00e+00 627.00
IUUC-Pan-091853 Papio anubis 99.62 3.00e-158 551.00
IUUC-Psi-093244 Pelodiscus sinensis 93.00 6.00e-143 500.00
IUUC-Pno-094768 Phaeosphaeria nodorum 37.63 4.00e-43 169.00
IUUC-Ppa-095402 Physcomitrella patens 36.51 5.00e-49 187.00
IUUC-Pfo-096308 Poecilia formosa 86.04 1.00e-164 572.00
IUUC-Pab-098622 Pongo abelii 99.61 5.00e-152 529.00
IUUC-Pop-099770 Populus trichocarpa 38.87 2.00e-45 176.00
IUUC-Pca-100732 Procavia capensis 96.37 3.00e-174 603.00
IUUC-Ppe-102094 Prunus persica 38.12 4.00e-49 188.00
IUUC-Pva-103208 Pteropus vampyrus 99.03 0.00e+00 636.00
IUUC-Pgr-103639 Puccinia graminis 35.56 4.00e-25 108.00
IUUC-Ptt-103851 Puccinia triticina 34.15 2.00e-32 133.00
IUUC-Pte-104134 Pyrenophora teres 42.32 4.00e-42 164.00
IUUC-Pyt-104660 Pyrenophora triticirepentis 42.19 5.00e-42 164.00
IUUC-Rno-104826 Rattus norvegicus 97.40 0.00e+00 627.00
IUUC-Sce-106237 Saccharomyces cerevisiae 32.18 1.00e-26 113.00
IUUC-Sha-107453 Sarcophilus harrisii 95.39 7.00e-176 609.00
IUUC-Sja-107686 Schizosaccharomyces japonicus 41.00 4.00e-47 181.00
IUUC-Spo-108110 Schizosaccharomyces pombe 41.73 2.00e-47 182.00
IUUC-Smo-108765 Selaginella moellendorffii 37.30 1.00e-47 183.00
IUUC-Sit-110416 Setaria italica 39.33 7.00e-51 194.00
IUUC-Sly-111184 Solanum lycopersicum 39.13 1.00e-51 196.00
IUUC-Stu-112187 Solanum tuberosum 38.80 6.00e-51 194.00
IUUC-Sar-113576 Sorex araneus 45.83 3.00e-28 118.00
IUUC-Sbi-114251 Sorghum bicolor 39.00 2.00e-50 192.00
IUUC-Sre-114975 Sporisorium reilianum 41.92 7.00e-56 210.00
IUUC-Ssc-115522 Sus scrofa 99.63 7.00e-161 559.00
IUUC-Tgu-116610 Taeniopygia guttata 72.70 1.00e-136 478.00
IUUC-Tru-118204 Takifugu rubripes 83.61 8.00e-161 559.00
IUUC-Tsy-119153 Tarsius syrichta 44.44 5.00e-76 278.00
IUUC-Tni-119738 Tetraodon nigroviridis 83.17 1.00e-160 558.00
IUUC-Tca-120950 Theobroma cacao 38.49 7.00e-51 194.00
IUUC-Tre-122109 Trichoderma reesei 36.05 2.00e-41 162.00
IUUC-Tvi-122473 Trichoderma virens 36.12 2.00e-42 165.00
IUUC-Tae-123617 Triticum aestivum 40.27 2.00e-51 195.00
IUUC-Tur-126035 Triticum urartu 43.28 5.00e-46 178.00
IUUC-Tme-127040 Tuber melanosporum 31.50 1.00e-34 140.00
IUUC-Tbe-127888 Tupaia belangeri 46.21 3.00e-36 145.00
IUUC-Ttr-128486 Tursiops truncatus 99.03 0.00e+00 635.00
IUUC-Uma-129516 Ustilago maydis 40.41 8.00e-53 200.00
IUUC-Vda-129861 Verticillium dahliae 37.10 1.00e-34 140.00
IUUC-Vpa-130704 Vicugna pacos 45.75 2.00e-80 292.00
IUUC-Vvi-131375 Vitis vinifera 37.85 4.00e-51 194.00
IUUC-Xtr-132795 Xenopus tropicalis 90.58 9.00e-172 595.00
IUUC-Xma-133866 Xiphophorus maculatus 85.71 2.00e-164 571.00
IUUC-Yli-134568 Yarrowia lipolytica 36.03 2.00e-41 163.00
IUUC-Zma-134891 Zea mays 39.38 2.00e-50 192.00
Created Date 25-Jun-2017

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