iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089251

Ensembl Protein ID

ENSOARP00000004472.1

UniProt Accession

W5P223; W5P223_SHEEP

Genbank Protein ID

ENSOARP00000004472

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AMGL01061750

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000004179.1	ENSOART00000004550.1	ENSOARP00000004472.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.80e-51	173.7	82	272

Active Site

Position(s)	Description	Evidence
89	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
92	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
266		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 82   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekrtpvadLLASFNDQSTSD 170
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 171  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHVFPEGS-E 255
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 256  PKVYLLYRPGHYDILYK 272
           ***************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

CPGRLLPSSC PRPSFLEWGE RVNCLAYDEA IMAQQDRIQQ EIAVQNPLVS ERLELSVLYK 60
EYAEDDNIYQ QKIKDLHKKY SYIRKTRPDG NCFYRAFGFS HLEALLDDSK ELQRFKAVSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCCTGGTC GTCTTTTACC TAACACCCAG GCCCCCTTGC ATTGGGAGCT CGGAGCCTTA 60
GCCACTGGAC CTCCAGGGAA GTCCCTGGCC TCCTCCCTTT AAAGATGAGA TAACTCATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	98.80	4.00e-147	513.00
IUUC-Apl-003233	Anas platyrhynchos	61.54	4.00e-20	88.60
IUUC-Aca-004648	Anolis carolinensis	88.98	2.00e-132	464.00
IUUC-Aly-005710	Arabidopsis lyrata	42.03	6.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	41.88	6.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.40
IUUC-Ame-010662	Astyanax mexicanus	84.98	3.00e-127	447.00
IUUC-Bta-013533	Bos taurus	99.60	4.00e-149	520.00
IUUC-Bol-016100	Brassica oleracea	40.71	2.00e-49	189.00
IUUC-Bra-017705	Brassica rapa	38.05	3.00e-44	171.00
IUUC-Cel-018295	Caenorhabditis elegans	33.21	1.00e-40	159.00
IUUC-Cja-019190	Callithrix jacchus	98.42	2.00e-147	514.00
IUUC-Cfa-020430	Canis familiaris	98.80	7.00e-147	512.00
IUUC-Cpo-022355	Cavia porcellus	98.81	4.00e-148	516.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.56	1.00e-45	176.00
IUUC-Csa-023286	Chlorocebus sabaeus	94.68	4.00e-145	506.00
IUUC-Cin-025507	Ciona intestinalis	43.33	3.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	49.80	1.00e-68	252.00
IUUC-Dre-027843	Danio rerio	81.27	7.00e-123	432.00
IUUC-Dno-029165	Dasypus novemcinctus	97.50	6.00e-116	409.00
IUUC-Dor-030943	Dipodomys ordii	98.81	4.00e-148	516.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	1.00e-77	282.00
IUUC-Ete-032296	Echinops telfairi	95.60	2.00e-87	315.00
IUUC-Eca-033695	Equus caballus	98.41	1.00e-146	511.00
IUUC-Fca-036441	Felis catus	94.76	3.00e-147	513.00
IUUC-Gmo-038908	Gadus morhua	82.21	2.00e-123	434.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	2.00e-32	134.00
IUUC-Gga-040460	Gallus gallus	83.27	2.00e-126	444.00
IUUC-Gac-042417	Gasterosteus aculeatus	80.80	4.00e-121	427.00
IUUC-Gma-043712	Glycine max	41.64	4.00e-50	191.00
IUUC-Ggo-044552	Gorilla gorilla	98.11	3.00e-90	324.00
IUUC-Hsa-046766	Homo sapiens	98.42	7.00e-148	516.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	98.81	4.00e-148	516.00
IUUC-Lch-050602	Latimeria chalumnae	78.46	1.00e-116	412.00
IUUC-Laf-053705	Loxodonta africana	98.81	4.00e-148	516.00
IUUC-Mcc-055745	Macaca mulatta	91.54	1.00e-143	502.00
IUUC-Meu-056569	Macropus eugenii	84.19	8.00e-123	432.00
IUUC-Mtr-057712	Medicago truncatula	40.89	1.00e-45	176.00
IUUC-Mvi-060358	Microbotryum violaceum	34.55	3.00e-15	75.50
IUUC-Mmr-061123	Microcebus murinus	97.67	2.00e-121	428.00
IUUC-Mdo-062613	Monodelphis domestica	87.35	1.00e-113	402.00
IUUC-Mmu-063658	Mus musculus	98.81	4.00e-148	516.00
IUUC-Mac-065274	Musa acuminata	38.00	4.00e-39	155.00
IUUC-Mpu-066172	Mustela putorius furo	98.42	7.00e-148	516.00
IUUC-Mlu-066966	Myotis lucifugus	97.64	3.00e-147	513.00
IUUC-Nle-069519	Nomascus leucogenys	86.10	7.00e-91	327.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	5.00e-124	436.00
IUUC-Ola-087331	Oryzias latipes	80.34	1.00e-84	305.00
IUUC-Oga-088064	Otolemur garnettii	98.42	7.00e-148	516.00
IUUC-Ptr-091430	Pan troglodytes	98.42	2.00e-147	514.00
IUUC-Psi-093823	Pelodiscus sinensis	89.37	1.00e-131	461.00
IUUC-Pma-094366	Petromyzon marinus	75.00	1.00e-100	358.00
IUUC-Pfo-096734	Poecilia formosa	80.48	4.00e-113	400.00
IUUC-Pab-097919	Pongo abelii	98.14	5.00e-121	426.00
IUUC-Pop-099401	Populus trichocarpa	40.88	2.00e-47	182.00
IUUC-Ppe-101977	Prunus persica	41.18	2.00e-52	199.00
IUUC-Pva-102499	Pteropus vampyrus	98.80	3.00e-147	513.00
IUUC-Rno-105233	Rattus norvegicus	98.81	4.00e-148	516.00
IUUC-Sha-107081	Sarcophilus harrisii	98.80	2.00e-146	511.00
IUUC-Sly-111640	Solanum lycopersicum	41.64	2.00e-48	185.00
IUUC-Ssc-116202	Sus scrofa	98.42	7.00e-148	516.00
IUUC-Tru-117664	Takifugu rubripes	79.07	3.00e-119	420.00
IUUC-Tca-121467	Theobroma cacao	41.18	1.00e-49	189.00
IUUC-Tbe-128116	Tupaia belangeri	96.89	3.00e-91	327.00
IUUC-Ttr-128622	Tursiops truncatus	97.63	5.00e-145	506.00
IUUC-Vvi-131389	Vitis vinifera	43.38	1.00e-51	196.00
IUUC-Xma-134191	Xiphophorus maculatus	80.88	5.00e-114	403.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence