iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167193.7	ENST00000398970.5	ENSP00000381942.5
ENSG00000167193.7	ENST00000300574.2	ENSP00000300574.2
ENSG00000167193.7	ENST00000574295.1	ENSP00000459505.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	PhosphoBase
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-18	66.6	134	189

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e+v++l+d++++++++L +kkGd++++   ++ +e W+++ ++ egkrG++P  +vek
   Q: 134  AEYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNA-EDSEGKRGMIPVPYVEK 189
           689*************************..6999******9.5**************98 PP

Organism

Homo sapiens

Functional Description
(View)

Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Protein Sequence
(Fasta)

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAAAATACA AAAATTAGCC AGGCAGGGTG GCGTGTGCCT GTAATCCCAG CTACTCGGAA 60
GGCTGAGGCA GGAGAATCCC TTGAACCCCG GAGGCGAAGG TTACAGTGAG CCGAGATTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046875--F:ephrin receptor binding
GO:0042169--F:SH2 domain binding
GO:0000186--P:activation of MAPKK activity
GO:1990859--P:cellular response to endothelin
GO:1990314--P:cellular response to insulin-like growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0071732--P:cellular response to nitric oxide
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045953--P:negative regulation of natural killer cell mediated cytotoxicity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0043087--P:regulation of GTPase activity
GO:0035020--P:regulation of Rac protein signal transduction
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0035728--P:response to hepatocyte growth factor
GO:0042542--P:response to hydrogen peroxide
GO:0001878--P:response to yeast
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:1398

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	99.67	2.00e-160	558.00
IUUC-Apl-003225	Anas platyrhynchos	92.00	9.00e-123	432.00
IUUC-Aca-004818	Anolis carolinensis	78.35	4.00e-93	333.00
IUUC-Ame-011721	Astyanax mexicanus	68.35	1.00e-118	419.00
IUUC-Bta-012320	Bos taurus	100.00	9.00e-164	569.00
IUUC-Cel-018307	Caenorhabditis elegans	30.33	3.00e-26	112.00
IUUC-Cja-019935	Callithrix jacchus	96.38	6.00e-168	583.00
IUUC-Cfa-021221	Canis familiaris	99.67	1.00e-163	569.00
IUUC-Cpo-021592	Cavia porcellus	86.82	3.00e-138	484.00
IUUC-Csa-024128	Chlorocebus sabaeus	100.00	8.00e-101	359.00
IUUC-Cho-024775	Choloepus hoffmanni	98.03	3.00e-162	563.00
IUUC-Dre-027390	Danio rerio	69.25	6.00e-120	423.00
IUUC-Dno-029847	Dasypus novemcinctus	100.00	9.00e-164	569.00
IUUC-Dor-030360	Dipodomys ordii	89.80	1.00e-156	545.00
IUUC-Ete-032604	Echinops telfairi	96.86	3.00e-126	444.00
IUUC-Eca-033233	Equus caballus	98.36	4.00e-163	566.00
IUUC-Eeu-034642	Erinaceus europaeus	97.31	3.00e-128	450.00
IUUC-Fca-035955	Felis catus	99.56	2.00e-131	461.00
IUUC-Fal-037152	Ficedula albicollis	86.83	2.00e-141	494.00
IUUC-Gmo-038849	Gadus morhua	67.72	5.00e-118	417.00
IUUC-Gga-040861	Gallus gallus	83.93	3.00e-150	524.00
IUUC-Gac-041627	Gasterosteus aculeatus	66.67	1.00e-120	426.00
IUUC-Ggo-045475	Gorilla gorilla	100.00	9.00e-164	569.00
IUUC-Itr-048906	Ictidomys tridecemlineatus	99.62	2.00e-134	471.00
IUUC-Lch-050509	Latimeria chalumnae	81.29	3.00e-148	517.00
IUUC-Loc-052229	Lepisosteus oculatus	73.53	2.00e-108	385.00
IUUC-Laf-053896	Loxodonta africana	95.11	5.00e-167	580.00
IUUC-Mcc-055280	Macaca mulatta	100.00	9.00e-164	569.00
IUUC-Meu-056783	Macropus eugenii	96.86	7.00e-127	446.00
IUUC-Mga-059345	Meleagris gallopavo	92.38	6.00e-124	436.00
IUUC-Mdo-062691	Monodelphis domestica	88.31	5.00e-154	536.00
IUUC-Mmu-063691	Mus musculus	99.67	2.00e-163	568.00
IUUC-Mpu-065737	Mustela putorius furo	99.67	9.00e-164	569.00
IUUC-Mlu-067005	Myotis lucifugus	96.71	4.00e-159	553.00
IUUC-Nle-070154	Nomascus leucogenys	99.56	3.00e-131	460.00
IUUC-Opr-071114	Ochotona princeps	98.36	5.00e-176	609.00
IUUC-Ont-071696	Oreochromis niloticus	69.75	1.00e-115	409.00
IUUC-Oan-072967	Ornithorhynchus anatinus	93.46	1.00e-132	465.00
IUUC-Ocu-074025	Oryctolagus cuniculus	99.01	2.00e-99	354.00
IUUC-Oga-088266	Otolemur garnettii	98.68	5.00e-163	566.00
IUUC-Oar-089221	Ovis aries	98.36	4.00e-159	553.00
IUUC-Ptr-091463	Pan troglodytes	95.39	1.00e-151	528.00
IUUC-Pan-092242	Papio anubis	99.67	9.00e-164	569.00
IUUC-Psi-093287	Pelodiscus sinensis	94.64	7.00e-127	446.00
IUUC-Pfo-097378	Poecilia formosa	66.46	1.00e-110	392.00
IUUC-Pab-097823	Pongo abelii	100.00	8.00e-101	359.00
IUUC-Pca-101068	Procavia capensis	100.00	9.00e-164	569.00
IUUC-Rno-105288	Rattus norvegicus	99.67	3.00e-163	567.00
IUUC-Sar-113453	Sorex araneus	84.54	7.00e-147	513.00
IUUC-Tgu-116926	Taeniopygia guttata	86.56	8.00e-150	523.00
IUUC-Tru-118656	Takifugu rubripes	66.87	2.00e-120	425.00
IUUC-Tni-120497	Tetraodon nigroviridis	68.81	7.00e-115	406.00
IUUC-Tbe-127436	Tupaia belangeri	95.07	8.00e-145	506.00
IUUC-Ttr-129109	Tursiops truncatus	100.00	1.00e-130	458.00
IUUC-Vpa-130527	Vicugna pacos	99.67	1.00e-161	562.00
IUUC-Xtr-131808	Xenopus tropicalis	84.59	3.00e-150	524.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence