iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-131814

Ensembl Protein ID

ENSXETP00000035203.3

UniProt Accession

F6W7P5; F6W7P5_XENTR

Genbank Protein ID

ENSXETP00000035203

Protein Name

GRB2-related adaptor protein 2

Genbank Nucleotide ID

AAMC01026138

Gene Name

grap2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000016137.3	ENSXETT00000035203.3	ENSXETP00000035203.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-30	103.6	3	52

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            q++y+++a+ +deL++kkGdv++++   + d +W k   el+g +G +P+n+ve
   Q: 3    AQAMYEFNASGEDELSFKKGDVLKIL---SSDDNWYKS--ELNGSEGYVPKNYVE 52
           589***********************...99*****88..**************8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MEAQAMYEFN ASGEDELSFK KGDVLKILSS DDNWYKSELN GSEGYVPKNY VEVHFPRWYC 60
ENISRGEAES ILIGRFVGAF IIRASQTSKG EFSMSVRDED DVQHFKVMRD IRGNYYLWTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGCCC AGGCAATGTA CGAGTTTAAT GCCTCTGGGG AAGATGAACT GAGCTTCAAA 60
AAAGGAGACG TGCTAAAGGT ATCTTCGTTA GTAATAAATG AATATTAACT CCATTAATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001994	Ailuropoda melanoleuca	48.19	3.00e-79	288.00
IUUC-Apl-003684	Anas platyrhynchos	49.24	3.00e-84	304.00
IUUC-Aca-005371	Anolis carolinensis	45.21	9.00e-77	280.00
IUUC-Ame-011392	Astyanax mexicanus	44.34	1.00e-69	256.00
IUUC-Bta-013508	Bos taurus	46.67	2.00e-75	275.00
IUUC-Bci-013708	Botrytis cinerea	51.79	1.00e-09	58.90
IUUC-Cfa-020290	Canis familiaris	46.97	4.00e-79	287.00
IUUC-Cpo-022534	Cavia porcellus	46.27	1.00e-78	285.00
IUUC-Csa-023438	Chlorocebus sabaeus	49.70	3.00e-80	291.00
IUUC-Cho-024466	Choloepus hoffmanni	49.02	3.00e-38	151.00
IUUC-Dre-027927	Danio rerio	64.63	2.00e-55	208.00
IUUC-Dno-029894	Dasypus novemcinctus	47.58	2.00e-79	288.00
IUUC-Dor-030493	Dipodomys ordii	63.40	2.00e-56	212.00
IUUC-Ete-032335	Echinops telfairi	41.69	1.00e-60	226.00
IUUC-Eca-033750	Equus caballus	48.18	1.00e-79	289.00
IUUC-Eeu-034884	Erinaceus europaeus	40.30	6.00e-50	190.00
IUUC-Fca-036001	Felis catus	46.67	4.00e-79	287.00
IUUC-Fal-036692	Ficedula albicollis	47.75	2.00e-80	291.00
IUUC-Gmo-039524	Gadus morhua	58.28	4.00e-49	187.00
IUUC-Gac-041301	Gasterosteus aculeatus	42.48	2.00e-67	248.00
IUUC-Ggo-045424	Gorilla gorilla	49.70	3.00e-80	291.00
IUUC-Hsa-045808	Homo sapiens	49.39	5.00e-80	290.00
IUUC-Itr-048000	Ictidomys tridecemlineatus	46.67	3.00e-76	278.00
IUUC-Lch-049610	Latimeria chalumnae	43.24	5.00e-60	224.00
IUUC-Loc-052925	Lepisosteus oculatus	43.43	4.00e-67	247.00
IUUC-Lma-052965	Leptosphaeria maculans	53.85	4.00e-09	57.80
IUUC-Laf-054004	Loxodonta africana	47.88	2.00e-80	292.00
IUUC-Mcc-055020	Macaca mulatta	49.70	3.00e-80	291.00
IUUC-Meu-056169	Macropus eugenii	66.67	4.00e-58	218.00
IUUC-Mga-059483	Meleagris gallopavo	47.04	2.00e-80	292.00
IUUC-Mmr-061755	Microcebus murinus	47.58	9.00e-80	290.00
IUUC-Mdo-062504	Monodelphis domestica	47.63	4.00e-78	285.00
IUUC-Mmu-063557	Mus musculus	46.36	2.00e-78	285.00
IUUC-Mpu-066852	Mustela putorius furo	46.36	1.00e-78	286.00
IUUC-Mlu-067510	Myotis lucifugus	46.88	2.00e-76	278.00
IUUC-Nle-069691	Nomascus leucogenys	49.39	9.00e-80	290.00
IUUC-Opr-070271	Ochotona princeps	45.67	5.00e-72	264.00
IUUC-Ont-072465	Oreochromis niloticus	60.15	3.00e-46	178.00
IUUC-Oan-073183	Ornithorhynchus anatinus	47.88	5.00e-79	287.00
IUUC-Ocu-074899	Oryctolagus cuniculus	41.57	1.00e-63	236.00
IUUC-Ome-081175	Oryza meridionalis	28.57	2.30e-01	27.70
IUUC-Ola-086462	Oryzias latipes	59.74	4.00e-52	197.00
IUUC-Oga-088553	Otolemur garnettii	47.60	2.00e-79	288.00
IUUC-Oar-089572	Ovis aries	46.53	2.00e-78	285.00
IUUC-Ptr-090582	Pan troglodytes	49.39	9.00e-80	290.00
IUUC-Pan-092063	Papio anubis	49.70	3.00e-80	291.00
IUUC-Psi-094056	Pelodiscus sinensis	48.65	3.00e-79	288.00
IUUC-Pfo-096115	Poecilia formosa	40.67	4.00e-63	234.00
IUUC-Pab-098217	Pongo abelii	49.39	2.00e-79	289.00
IUUC-Pca-100838	Procavia capensis	46.97	8.00e-77	280.00
IUUC-Pva-102559	Pteropus vampyrus	55.85	2.00e-58	219.00
IUUC-Rno-105926	Rattus norvegicus	38.32	9.00e-58	216.00
IUUC-Sha-106948	Sarcophilus harrisii	47.01	1.00e-74	272.00
IUUC-Ssc-115605	Sus scrofa	47.45	1.00e-78	286.00
IUUC-Tgu-117211	Taeniopygia guttata	47.32	9.00e-79	286.00
IUUC-Tru-118347	Takifugu rubripes	60.39	3.00e-54	204.00
IUUC-Tsy-119441	Tarsius syrichta	46.57	8.00e-77	280.00
IUUC-Tni-119732	Tetraodon nigroviridis	44.19	5.00e-70	257.00
IUUC-Tme-127036	Tuber melanosporum	45.61	2.00e-09	58.50
IUUC-Tbe-127289	Tupaia belangeri	43.69	1.00e-61	229.00
IUUC-Ttr-128961	Tursiops truncatus	45.15	1.00e-76	279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence