iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062263

UUCD1 version

UUC-MoD-00310

Ensembl Protein ID

ENSMODP00000024343.2

UniProt Accession

F6VDA7; F6VDA7_MONDO

Protein Name

Uncharacterized protein

Gene Name

RBCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019512.2	ENSMODT00000024773.2	ENSMODP00000024343.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.20e-06	26.8	288	331
ULD/UDP/UBQ/UBQ_Other	1.90e-07	31.0	70	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C+iC+ ++   +g+++  C H+f++dClq      ns+  e +CP+
   Q: 288  CPICYLSLgpGEGVVLRECLHAFCKDCLQGT--ILNSQEAEVSCPY 331
           ****99998877799999**********655..4577899999997 PP

ULD/UDP/UBQ/UBQ_Other

   S: 16   k....vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           +    v p +tVa LK++++   g++p  qr+++ G+ L +d +tL +yg++++
   Q: 70   HiwlmVRPNMTVASLKDMVFLDYGFHPSLQRWVI-GQRLpRDQDTLHSYGVRQD 122
           355668****************************.99999*********99643 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEEKTKKVEE MALKLARAVA GGDEKMAVTC ATWLAKNRTP LTLQLISEVY PKQEIKLWVG 60
MEDAQMHTLH IWLMVRPNMT VASLKDMVFL DYGFHPSLQR WVIGQRLPRD QDTLHSYGVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCAATGAG AAATCTCCAA TTCGTGACTC AGCCTTCTCC GGTCCCCGCC CCCTCCGGGC 60
CCTGGACGTA TCCGGTTCCT CTCCCCTCCG CCTCTGCCCT CACCCGGACT GTCGTTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR029071--Ubiquitin-rel_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

KEGG

mdo:100011102

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	77.13	0.00e+00	743.00
IUUC-Apl-003627	Anas platyrhynchos	48.84	9.00e-15	71.20
IUUC-Aca-004507	Anolis carolinensis	66.08	3.00e-168	584.00
IUUC-Ame-011008	Astyanax mexicanus	50.77	1.00e-151	529.00
IUUC-Bta-013247	Bos taurus	76.94	0.00e+00	743.00
IUUC-Bci-013637	Botrytis cinerea	26.60	3.00e-12	67.40
IUUC-Cja-018880	Callithrix jacchus	77.33	0.00e+00	745.00
IUUC-Cfa-020477	Canis familiaris	77.26	0.00e+00	731.00
IUUC-Cpo-021558	Cavia porcellus	76.36	0.00e+00	736.00
IUUC-Csa-024129	Chlorocebus sabaeus	76.74	0.00e+00	730.00
IUUC-Cin-025630	Ciona intestinalis	39.52	5.00e-89	321.00
IUUC-Csv-026069	Ciona savignyi	52.00	1.00e-81	295.00
IUUC-Dre-027591	Danio rerio	51.73	2.00e-150	525.00
IUUC-Dno-029015	Dasypus novemcinctus	76.36	0.00e+00	757.00
IUUC-Dor-030313	Dipodomys ordii	69.88	0.00e+00	663.00
IUUC-Ete-032908	Echinops telfairi	67.79	1.00e-178	619.00
IUUC-Eca-034295	Equus caballus	67.58	0.00e+00	661.00
IUUC-Eeu-034454	Erinaceus europaeus	66.78	3.00e-91	329.00
IUUC-Fca-036380	Felis catus	78.29	0.00e+00	755.00
IUUC-Fal-037440	Ficedula albicollis	61.67	4.00e-18	82.00
IUUC-Gmo-038561	Gadus morhua	53.36	3.00e-123	435.00
IUUC-Gga-040198	Gallus gallus	40.67	5.00e-33	134.00
IUUC-Gac-041319	Gasterosteus aculeatus	51.84	1.00e-142	499.00
IUUC-Ggo-044456	Gorilla gorilla	54.01	6.00e-135	474.00
IUUC-Hsa-045738	Homo sapiens	76.74	0.00e+00	730.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	75.63	0.00e+00	731.00
IUUC-Lch-050269	Latimeria chalumnae	46.00	2.00e-122	433.00
IUUC-Loc-052776	Lepisosteus oculatus	63.92	4.00e-116	412.00
IUUC-Laf-054269	Loxodonta africana	75.97	0.00e+00	733.00
IUUC-Mcc-055669	Macaca mulatta	77.71	0.00e+00	734.00
IUUC-Mga-059615	Meleagris gallopavo	60.61	8.00e-20	87.80
IUUC-Mmr-061562	Microcebus murinus	78.52	0.00e+00	665.00
IUUC-Mmu-064325	Mus musculus	77.13	0.00e+00	744.00
IUUC-Mpu-066385	Mustela putorius furo	77.52	0.00e+00	748.00
IUUC-Mlu-067000	Myotis lucifugus	77.26	0.00e+00	744.00
IUUC-Nle-069812	Nomascus leucogenys	77.52	0.00e+00	728.00
IUUC-Opr-070575	Ochotona princeps	91.18	3.00e-107	382.00
IUUC-Ont-071314	Oreochromis niloticus	49.35	3.00e-134	472.00
IUUC-Ocu-074358	Oryctolagus cuniculus	69.64	0.00e+00	662.00
IUUC-Ola-087012	Oryzias latipes	50.77	2.00e-150	526.00
IUUC-Oga-087986	Otolemur garnettii	75.39	0.00e+00	725.00
IUUC-Oar-089600	Ovis aries	75.58	0.00e+00	750.00
IUUC-Ptr-091224	Pan troglodytes	76.55	0.00e+00	728.00
IUUC-Pan-092739	Papio anubis	77.91	0.00e+00	736.00
IUUC-Pma-094407	Petromyzon marinus	47.73	4.00e-138	484.00
IUUC-Pfo-096767	Poecilia formosa	51.59	4.00e-155	541.00
IUUC-Pab-098627	Pongo abelii	76.55	0.00e+00	723.00
IUUC-Pca-100641	Procavia capensis	77.55	0.00e+00	719.00
IUUC-Pva-102670	Pteropus vampyrus	76.45	0.00e+00	745.00
IUUC-Rno-105504	Rattus norvegicus	75.78	0.00e+00	728.00
IUUC-Sha-107342	Sarcophilus harrisii	93.41	0.00e+00	967.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	28.57	8.00e-03	35.00
IUUC-Sar-113425	Sorex araneus	82.25	4.00e-110	391.00
IUUC-Ssc-115904	Sus scrofa	91.33	2.00e-95	340.00
IUUC-Tru-118096	Takifugu rubripes	51.34	5.00e-144	504.00
IUUC-Tni-119873	Tetraodon nigroviridis	48.82	2.00e-145	508.00
IUUC-Tbe-127578	Tupaia belangeri	78.32	0.00e+00	628.00
IUUC-Ttr-129107	Tursiops truncatus	76.36	0.00e+00	718.00
IUUC-Vpa-130353	Vicugna pacos	72.73	2.00e-95	342.00
IUUC-Xtr-132168	Xenopus tropicalis	40.28	4.00e-95	341.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence