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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046651
UUCD1 version UUC-HoS-00923
Ensembl Protein ID ENSP00000328203.2
UniProt Accession Q9BWF2; B5BU84; B5BUL3; O00467; TRAIP_HUMAN
Genbank Protein ID AAB52993.1; BAG70134.1; BAG70263.1; AAH00310.1; AAH19283.1
Protein Name E3 ubiquitin-protein ligase TRAIP; RING finger protein 206; RING-type E3 ubiquitin transferase TRAIP; TRAF-interacting protein
Genbank Nucleotide ID U77845; AB451320; AB451449; BC000310; BC019283
Gene Name TRAIP; RNF206; TRIP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183763.8 ENST00000331456.6 ENSP00000328203.2
ENSG00000183763.8 ENST00000473195.5 ENSP00000419556.1
ENSG00000183763.8 ENST00000469027.5 ENSP00000420085.1
ENSG00000183763.8 ENST00000482582.5 ENSP00000418544.1
ENSG00000183763.8 ENST00000482243.1 ENSP00000419350.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17544371; 21068752
Classification
Family E-value Score Start End
E3 activity/RING/RING 9.10e-06 27.8 7 50
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC + f   +d +    CgH+fh++Cl +w     ++ ++ +CP Cr
   Q: 7    CTICSDFFdhsRD-VAAIHCGHTFHLQCLIQW----FETAPSRTCPQCR 50
           9***776655344.88999*************....9***********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).
 E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769).
Protein Sequence
(Fasta)
MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN 60
KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS 120
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Protein Fasta Sequence


>IUUC-Hsa-046651|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCGCTCCAGG AAGTCGTGCT GCGGAGCCAA ATTTGAAGCA AGCGGAGGCG CGGGGGCGCG 60
TCTACGAAGC CGGACCTGTA GCAGTTTCTT TGGCTGCCTG GGCCCCTTGA GTCCAGCCAT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046651|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0242--Dwarfism
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0008283--P:cell proliferation
GO:0032688--P:negative regulation of interferon-beta production
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165--P:signal transduction
KEGG hsa:10293
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001411 Ailuropoda melanoleuca 81.78 0.00e+00 733.00
IUUC-Atr-002646 Amborella trichopoda 28.93 9.00e-08 52.00
IUUC-Apl-003777 Anas platyrhynchos 57.57 3.00e-109 388.00
IUUC-Aca-004476 Anolis carolinensis 57.32 2.00e-143 502.00
IUUC-Ame-011706 Astyanax mexicanus 49.30 2.00e-08 50.10
IUUC-Bta-013084 Bos taurus 81.53 0.00e+00 754.00
IUUC-Cel-018227 Caenorhabditis elegans 39.06 2.00e-11 63.50
IUUC-Cja-019856 Callithrix jacchus 94.24 0.00e+00 884.00
IUUC-Cfa-020075 Canis familiaris 84.65 0.00e+00 808.00
IUUC-Cpo-022481 Cavia porcellus 81.91 0.00e+00 772.00
IUUC-Csa-023793 Chlorocebus sabaeus 95.74 0.00e+00 918.00
IUUC-Csv-026190 Ciona savignyi 32.09 8.00e-42 164.00
IUUC-Dre-027984 Danio rerio 48.55 6.00e-121 427.00
IUUC-Dno-029478 Dasypus novemcinctus 83.55 0.00e+00 788.00
IUUC-Dor-030526 Dipodomys ordii 62.05 4.00e-162 564.00
IUUC-Dme-032130 Drosophila melanogaster 28.36 7.00e-22 98.60
IUUC-Ete-033012 Echinops telfairi 74.10 0.00e+00 664.00
IUUC-Eca-034084 Equus caballus 86.78 0.00e+00 832.00
IUUC-Eeu-034579 Erinaceus europaeus 76.05 2.00e-178 618.00
IUUC-Fca-035772 Felis catus 86.35 0.00e+00 801.00
IUUC-Fal-037098 Ficedula albicollis 59.51 2.00e-140 492.00
IUUC-Gmo-038704 Gadus morhua 46.88 5.00e-111 394.00
IUUC-Gga-041109 Gallus gallus 54.08 2.00e-136 479.00
IUUC-Gac-042636 Gasterosteus aculeatus 45.24 2.00e-114 405.00
IUUC-Ggo-045184 Gorilla gorilla 98.51 0.00e+00 945.00
IUUC-Itr-048550 Ictidomys tridecemlineatus 85.71 0.00e+00 830.00
IUUC-Lch-049575 Latimeria chalumnae 55.72 1.00e-127 449.00
IUUC-Loc-051999 Lepisosteus oculatus 49.33 2.00e-117 416.00
IUUC-Lma-053133 Leptosphaeria maculans 41.07 6.00e-08 51.20
IUUC-Laf-053347 Loxodonta africana 86.54 0.00e+00 818.00
IUUC-Mcc-054668 Macaca mulatta 94.39 3.00e-105 374.00
IUUC-Meu-056862 Macropus eugenii 63.03 8.00e-163 566.00
IUUC-Mga-059443 Meleagris gallopavo 55.04 2.00e-112 399.00
IUUC-Mmr-061219 Microcebus murinus 84.47 0.00e+00 790.00
IUUC-Mdo-062103 Monodelphis domestica 70.94 0.00e+00 649.00
IUUC-Mmu-064005 Mus musculus 79.70 0.00e+00 760.00
IUUC-Mac-064444 Musa acuminata 22.87 1.00e-06 47.80
IUUC-Mpu-066570 Mustela putorius furo 84.01 0.00e+00 781.00
IUUC-Mlu-067806 Myotis lucifugus 83.65 0.00e+00 785.00
IUUC-Nle-069123 Nomascus leucogenys 97.87 0.00e+00 920.00
IUUC-Opr-071063 Ochotona princeps 84.43 0.00e+00 808.00
IUUC-Ont-071973 Oreochromis niloticus 49.57 2.00e-120 425.00
IUUC-Oan-073278 Ornithorhynchus anatinus 69.86 6.00e-103 367.00
IUUC-Ocu-074582 Oryctolagus cuniculus 79.41 0.00e+00 729.00
IUUC-Oin-079866 Oryza indica 22.93 3.00e-07 50.40
IUUC-Osa-085981 Oryza sativa 23.84 3.00e-07 50.40
IUUC-Ola-086959 Oryzias latipes 47.83 1.00e-107 382.00
IUUC-Oga-088807 Otolemur garnettii 85.56 0.00e+00 776.00
IUUC-Oar-089273 Ovis aries 78.60 0.00e+00 736.00
IUUC-Ptr-090768 Pan troglodytes 98.93 0.00e+00 953.00
IUUC-Pan-091880 Papio anubis 95.95 0.00e+00 920.00
IUUC-Psi-093782 Pelodiscus sinensis 64.00 4.00e-137 481.00
IUUC-Pma-094365 Petromyzon marinus 38.90 3.00e-65 242.00
IUUC-Ppa-095896 Physcomitrella patens 25.12 2.00e-07 50.80
IUUC-Pfo-096068 Poecilia formosa 48.94 3.00e-110 391.00
IUUC-Pab-098063 Pongo abelii 95.32 0.00e+00 903.00
IUUC-Pca-100327 Procavia capensis 89.31 5.00e-180 623.00
IUUC-Pva-102924 Pteropus vampyrus 84.86 0.00e+00 794.00
IUUC-Pgr-103587 Puccinia graminis 42.86 5.00e-06 45.80
IUUC-Pte-104366 Pyrenophora teres 39.44 6.00e-07 48.10
IUUC-Rno-105799 Rattus norvegicus 81.41 0.00e+00 771.00
IUUC-Sha-107643 Sarcophilus harrisii 67.13 1.00e-160 559.00
IUUC-Sit-109687 Setaria italica 36.23 1.00e-06 48.10
IUUC-Sar-113187 Sorex araneus 78.09 0.00e+00 676.00
IUUC-Sbi-114760 Sorghum bicolor 36.23 1.00e-06 48.50
IUUC-Ssc-115838 Sus scrofa 89.79 8.00e-147 512.00
IUUC-Tgu-116674 Taeniopygia guttata 58.18 3.00e-128 451.00
IUUC-Tru-117753 Takifugu rubripes 45.42 5.00e-109 388.00
IUUC-Tsy-119416 Tarsius syrichta 72.83 1.00e-67 250.00
IUUC-Tni-120767 Tetraodon nigroviridis 47.43 2.00e-107 382.00
IUUC-Tur-126115 Triticum urartu 24.14 7.00e-07 50.10
IUUC-Tbe-128001 Tupaia belangeri 52.66 1.00e-85 310.00
IUUC-Ttr-128687 Tursiops truncatus 85.14 0.00e+00 811.00
IUUC-Xtr-131905 Xenopus tropicalis 53.72 1.00e-138 486.00
IUUC-Xma-133304 Xiphophorus maculatus 48.40 5.00e-109 387.00
Created Date 25-Jun-2017

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