iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-087980

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03174446

Gene Name

KLHL22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000016014.2	ENSOGAT00000016019.2	ENSOGAP00000014341.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.20e-19	69.6	50	114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	9.90e-08	31.3	149	178

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lvv+g++++ah+i Laas+++F+ +f ++l+e++ +++v i++v++ ++ ++l+F+Yt++l++
   Q: 50   DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEME-QEEVLIHGVSYNAMCQILHFIYTSELEL 114
           9***********************************8.*************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
           eN l+++r+A+l+d+++L ++ +++ilk+F
   Q: 149  ENILDVYRLAELFDLSRLTEQLDTYILKNF 178
           8***************************** PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAEEQEFTQL CKLPAQPSQH CINNTYRSAQ HSQALLRGLL ALRDSGILFD VVLVVEGRHI 60
EAHRILLAAS CDYFRGMFAG GLKEMEQEEV LIHGVSYNAM CQILHFIYTS ELELSLSNVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCGAGTG CGGCCTCGGC TTGCGGCGGC TCCAGGTCAG CTGTGAAACG TGGGCCGGGC 60
GGCTGAGAGC GCGGGCAGCG GGCTGCGGGC AGGCGGGCGG GGCCGGGGGC GAGAGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030575--KLHL22
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005813--C:centrosome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0000070--P:mitotic sister chromatid segregation
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0006513--P:protein monoubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002097	Ailuropoda melanoleuca	97.32	0.00e+00	1227.00
IUUC-Apl-004081	Anas platyrhynchos	77.12	0.00e+00	1017.00
IUUC-Aca-005015	Anolis carolinensis	65.81	0.00e+00	842.00
IUUC-Ame-011712	Astyanax mexicanus	59.70	0.00e+00	722.00
IUUC-Bta-012594	Bos taurus	93.22	0.00e+00	1211.00
IUUC-Bci-013875	Botrytis cinerea	30.38	3.00e-18	85.90
IUUC-Cja-019752	Callithrix jacchus	96.24	0.00e+00	1023.00
IUUC-Cfa-020884	Canis familiaris	97.48	0.00e+00	1264.00
IUUC-Cpo-021711	Cavia porcellus	96.21	0.00e+00	1248.00
IUUC-Csa-023211	Chlorocebus sabaeus	97.16	0.00e+00	1258.00
IUUC-Dre-028395	Danio rerio	59.61	0.00e+00	753.00
IUUC-Dno-030096	Dasypus novemcinctus	93.42	0.00e+00	1213.00
IUUC-Dor-030709	Dipodomys ordii	95.41	0.00e+00	696.00
IUUC-Eca-033388	Equus caballus	97.95	0.00e+00	1270.00
IUUC-Eeu-034616	Erinaceus europaeus	85.33	0.00e+00	1094.00
IUUC-Fca-035815	Felis catus	97.00	0.00e+00	1261.00
IUUC-Fal-037311	Ficedula albicollis	79.19	0.00e+00	1001.00
IUUC-Gmo-039571	Gadus morhua	52.52	2.00e-158	551.00
IUUC-Gga-040992	Gallus gallus	76.96	0.00e+00	1017.00
IUUC-Gac-042041	Gasterosteus aculeatus	56.04	0.00e+00	692.00
IUUC-Ggo-045141	Gorilla gorilla	91.48	0.00e+00	1183.00
IUUC-Hsa-045984	Homo sapiens	97.32	0.00e+00	1261.00
IUUC-Itr-048890	Ictidomys tridecemlineatus	97.79	0.00e+00	1266.00
IUUC-Lch-049700	Latimeria chalumnae	61.06	0.00e+00	733.00
IUUC-Loc-052141	Lepisosteus oculatus	61.36	0.00e+00	805.00
IUUC-Laf-053487	Loxodonta africana	94.29	0.00e+00	1213.00
IUUC-Mcc-054682	Macaca mulatta	96.50	0.00e+00	1004.00
IUUC-Meu-055937	Macropus eugenii	74.61	0.00e+00	969.00
IUUC-Mga-059953	Meleagris gallopavo	76.96	0.00e+00	1017.00
IUUC-Mmr-061743	Microcebus murinus	98.42	0.00e+00	1298.00
IUUC-Mdo-062328	Monodelphis domestica	82.76	0.00e+00	1090.00
IUUC-Mmu-063979	Mus musculus	93.78	0.00e+00	1209.00
IUUC-Mpu-066750	Mustela putorius furo	97.00	0.00e+00	1260.00
IUUC-Mlu-066960	Myotis lucifugus	95.27	0.00e+00	1236.00
IUUC-Nle-069690	Nomascus leucogenys	97.49	0.00e+00	1136.00
IUUC-Opr-071059	Ochotona princeps	89.61	0.00e+00	1142.00
IUUC-Ont-072004	Oreochromis niloticus	58.72	0.00e+00	687.00
IUUC-Oan-073172	Ornithorhynchus anatinus	63.08	0.00e+00	736.00
IUUC-Ocu-074310	Oryctolagus cuniculus	96.59	2.00e-156	544.00
IUUC-Ola-086599	Oryzias latipes	57.54	0.00e+00	702.00
IUUC-Oar-089956	Ovis aries	78.18	0.00e+00	904.00
IUUC-Ptr-090598	Pan troglodytes	97.32	0.00e+00	1139.00
IUUC-Pan-092387	Papio anubis	96.30	0.00e+00	1004.00
IUUC-Psi-093484	Pelodiscus sinensis	78.53	0.00e+00	1045.00
IUUC-Pma-094224	Petromyzon marinus	49.92	9.00e-173	600.00
IUUC-Pfo-096149	Poecilia formosa	57.80	0.00e+00	714.00
IUUC-Pab-098097	Pongo abelii	97.16	0.00e+00	1261.00
IUUC-Pca-100118	Procavia capensis	95.68	0.00e+00	697.00
IUUC-Pva-103174	Pteropus vampyrus	96.58	9.00e-158	550.00
IUUC-Rno-105350	Rattus norvegicus	94.32	0.00e+00	1196.00
IUUC-Sce-106328	Saccharomyces cerevisiae	26.26	2.30e+00	27.30
IUUC-Sha-106817	Sarcophilus harrisii	82.40	3.00e-134	472.00
IUUC-Sar-113490	Sorex araneus	96.50	0.00e+00	651.00
IUUC-Ssc-115827	Sus scrofa	94.79	0.00e+00	1235.00
IUUC-Tgu-116748	Taeniopygia guttata	81.37	0.00e+00	896.00
IUUC-Tru-118644	Takifugu rubripes	57.84	0.00e+00	693.00
IUUC-Tsy-118888	Tarsius syrichta	90.50	0.00e+00	1036.00
IUUC-Tni-120060	Tetraodon nigroviridis	54.28	1.00e-175	609.00
IUUC-Ttr-129183	Tursiops truncatus	94.80	0.00e+00	1110.00
IUUC-Xtr-132780	Xenopus tropicalis	69.89	0.00e+00	904.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence