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Tag Content
UUCD2 ID IUUC-Ptr-090455
UUCD1 version UUC-PaT-00263
Ensembl Protein ID ENSPTRP00000011670.4
UniProt Accession H2Q918; H2Q918_PANTR
Genbank Protein ID JAA25314.1
Protein Name Ubiquitin protein ligase E3A
Genbank Nucleotide ID AACZ03100802
Gene Name UBE3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPTRG00000006829.4 ENSPTRT00000012606.4 ENSPTRP00000011670.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 7.30e-108 360.9 548 874
Active Site
Position(s) Description Evidence
843 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 548  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 631
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 632  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 718
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 719  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 807
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 808  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
           *****************...8888866666**************************************97 PP
   
Organism Pan troglodytes
Protein Sequence
(Fasta)
MEKLHQCYWK SGEPQSDDIE ASRMKRAAAK HLIERYYHQL TEGCGNEACT NEFCASCPTF 60
LRMDNNAAAI KALELYKINA KLCDPHPSKK GASSAYLENS KGAPNNSCSE IKMNKKGARI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ptr-090455|E3,HECT|Pan troglodytes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGAAGC TGCACCAGTG TTATTGGAAG TGAGCCACCA TTTGAATTTG CTAGCTCATG 60
CTGCAGTATT CAGATTAGTG GGTGTTTTGT GATCATATTT TCTGCGATTC AAATCAAGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ptr-090455|E3,HECT|Pan troglodytes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 98.24 0.00e+00 1612.00
IUUC-Atr-003144 Amborella trichopoda 45.80 8.00e-96 343.00
IUUC-Apl-003742 Anas platyrhynchos 91.32 0.00e+00 1587.00
IUUC-Aca-004873 Anolis carolinensis 93.30 0.00e+00 1600.00
IUUC-Ame-011166 Astyanax mexicanus 86.83 0.00e+00 1452.00
IUUC-Bta-013286 Bos taurus 97.13 0.00e+00 1583.00
IUUC-Cja-019707 Callithrix jacchus 99.54 0.00e+00 1684.00
IUUC-Cfa-020154 Canis familiaris 97.70 0.00e+00 1620.00
IUUC-Cpo-021292 Cavia porcellus 97.66 0.00e+00 1602.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 49.06 2.00e-82 298.00
IUUC-Csa-023378 Chlorocebus sabaeus 99.65 0.00e+00 1665.00
IUUC-Cho-025059 Choloepus hoffmanni 93.81 0.00e+00 1512.00
IUUC-Cin-025643 Ciona intestinalis 44.91 0.00e+00 714.00
IUUC-Csv-026282 Ciona savignyi 45.10 0.00e+00 673.00
IUUC-Cme-027151 Cyanidioschyzon merolae 44.02 4.00e-101 363.00
IUUC-Dre-027901 Danio rerio 86.23 0.00e+00 1437.00
IUUC-Dno-029320 Dasypus novemcinctus 97.37 0.00e+00 1625.00
IUUC-Dor-030756 Dipodomys ordii 95.41 0.00e+00 744.00
IUUC-Dme-032035 Drosophila melanogaster 42.86 1.00e-165 577.00
IUUC-Eca-033843 Equus caballus 98.01 0.00e+00 1574.00
IUUC-Eeu-035109 Erinaceus europaeus 96.36 0.00e+00 1561.00
IUUC-Fca-036344 Felis catus 95.99 0.00e+00 1618.00
IUUC-Fal-036747 Ficedula albicollis 91.32 0.00e+00 1588.00
IUUC-Gmo-038840 Gadus morhua 63.58 0.00e+00 1103.00
IUUC-Gga-040399 Gallus gallus 91.21 0.00e+00 1586.00
IUUC-Gac-041933 Gasterosteus aculeatus 84.36 0.00e+00 1394.00
IUUC-Ggo-044804 Gorilla gorilla 100.00 0.00e+00 1692.00
IUUC-Hsa-045727 Homo sapiens 100.00 0.00e+00 1692.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 94.50 0.00e+00 1519.00
IUUC-Lch-050197 Latimeria chalumnae 91.01 0.00e+00 1548.00
IUUC-Loc-052743 Lepisosteus oculatus 88.63 0.00e+00 1521.00
IUUC-Lma-053245 Leptosphaeria maculans 33.87 4.00e-57 216.00
IUUC-Laf-053615 Loxodonta africana 96.08 0.00e+00 1607.00
IUUC-Mcc-054934 Macaca mulatta 99.20 0.00e+00 1666.00
IUUC-Meu-056061 Macropus eugenii 90.26 0.00e+00 1426.00
IUUC-Mga-059271 Meleagris gallopavo 90.71 0.00e+00 1561.00
IUUC-Mmr-061288 Microcebus murinus 98.40 0.00e+00 1659.00
IUUC-Mdo-062975 Monodelphis domestica 95.54 0.00e+00 1603.00
IUUC-Mmu-063674 Mus musculus 95.40 0.00e+00 1576.00
IUUC-Mpu-066568 Mustela putorius furo 98.05 0.00e+00 1646.00
IUUC-Mlu-067522 Myotis lucifugus 88.95 0.00e+00 1497.00
IUUC-Nle-069505 Nomascus leucogenys 100.00 0.00e+00 1692.00
IUUC-Opr-070570 Ochotona princeps 89.77 0.00e+00 1461.00
IUUC-Ont-071527 Oreochromis niloticus 84.65 0.00e+00 1464.00
IUUC-Oan-073446 Ornithorhynchus anatinus 90.59 0.00e+00 1053.00
IUUC-Ocu-074922 Oryctolagus cuniculus 95.56 0.00e+00 1626.00
IUUC-Ola-086996 Oryzias latipes 85.51 0.00e+00 1466.00
IUUC-Oga-088261 Otolemur garnettii 98.94 0.00e+00 1629.00
IUUC-Oar-090024 Ovis aries 97.13 0.00e+00 1583.00
IUUC-Pan-092509 Papio anubis 98.37 0.00e+00 1522.00
IUUC-Psi-092974 Pelodiscus sinensis 91.43 0.00e+00 1555.00
IUUC-Pma-094643 Petromyzon marinus 71.72 0.00e+00 1259.00
IUUC-Pno-094886 Phaeosphaeria nodorum 35.32 8.00e-58 219.00
IUUC-Pfo-096905 Poecilia formosa 85.35 0.00e+00 1461.00
IUUC-Pab-097840 Pongo abelii 97.54 0.00e+00 1597.00
IUUC-Pca-100869 Procavia capensis 96.84 0.00e+00 1590.00
IUUC-Pva-103040 Pteropus vampyrus 97.02 0.00e+00 667.00
IUUC-Rno-105453 Rattus norvegicus 95.63 0.00e+00 1581.00
IUUC-Sha-107651 Sarcophilus harrisii 95.54 0.00e+00 1603.00
IUUC-Smo-108858 Selaginella moellendorffii 49.65 6.00e-116 411.00
IUUC-Sar-113293 Sorex araneus 97.43 0.00e+00 1597.00
IUUC-Ssc-115979 Sus scrofa 97.54 0.00e+00 1598.00
IUUC-Tgu-116901 Taeniopygia guttata 91.32 0.00e+00 1587.00
IUUC-Tru-118368 Takifugu rubripes 86.01 0.00e+00 1462.00
IUUC-Tsy-119516 Tarsius syrichta 94.95 0.00e+00 1518.00
IUUC-Tni-120143 Tetraodon nigroviridis 83.83 0.00e+00 1454.00
IUUC-Tbe-127484 Tupaia belangeri 92.76 0.00e+00 1108.00
IUUC-Ttr-129078 Tursiops truncatus 97.31 0.00e+00 1570.00
IUUC-Vpa-130312 Vicugna pacos 90.05 0.00e+00 1353.00
IUUC-Xtr-132881 Xenopus tropicalis 91.59 0.00e+00 1551.00
Created Date 25-Jun-2017

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