iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007096

UUCD1 version

UUC-ArT-01507

Ensembl Protein ID

AT5G39550.1

UniProt Accession

Q9FKA7; Q67XP0; ORTH1_ARATH

Genbank Protein ID

BAB08886.1; AED94446.1; AAQ65196.1; BAD44541.1; BAD93904.1

Protein Name

E3 ubiquitin-protein ligase ORTHRUS 1; Protein VARIANT IN METHYLATION 3; RING-type E3 ubiquitin transferase ORTHRUS 1

Genbank Nucleotide ID

AB012243; CP002688; BT010573; AK176778; AK221256

Gene Name

ORTH1; VIM3; At5g39550; MIJ24.3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G39550	AT5G39550.1	AT5G39550.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18643997

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	8.80e-07	29.8	127	173
E3 activity/RING/RING	1.30e-13	52.1	129	169

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplt 51
             C+I  +l++ P ++p+G+ +  ++ ekw   +gk tc ++r+++ 
   Q: 127  IFCSICIQLPERPITTPCGHNFCLKCFEKWAVGQGKlTCMICRSKIP 173
           57*****************************999999*****99985 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC + +++ p+++pCgH f+++C++kw     + +++ +C +Cr
   Q: 129  CSICIQLPER-PITTPCGHNFCLKCFEKW----AVGQGKLTCMICR 169
           **********.******************....99**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e.g. UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate.

Protein Sequence
(Fasta)

MAIETQLPCD GDGVCMRCQV NPPSEETLTC GTCVTPWHVP CLLPESLASS TGEWECPDCS 60
GVVVPSAAPG TGNARPESSG SVLVAAIRAI QADETLTEAE KAKKRQKLMS GGGDDGVDEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTTTTCT TTTTTAGGTT TTTACAAATC ATTTTGAAAT TCACTCTTCG CCTTCCCCAA 60
AATTTCAAAA CCCGCCTCTT CACTTTTCGC CTTCCTCTAC TTATTTAGCC TAAATCTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015947--PUA-like_domain
IPR003105--SRA_YDG
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51015--YDG
PS01359--ZF_PHD_1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02182--SAD_SRA
PF13445--zf-RING_UBOX

SMART

SM00249--PHD
SM00184--RING
SM00466--SRA

Gene Ontology

GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0010429--F:methyl-CpNpN binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0032776--P:DNA methylation on cytosine
GO:0010424--P:DNA methylation on cytosine within a CG sequence
GO:0010216--P:maintenance of DNA methylation
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0016567--P:protein ubiquitination
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT5G39550

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001401	Ailuropoda melanoleuca	33.25	2.00e-47	183.00
IUUC-Apl-003819	Anas platyrhynchos	36.12	1.00e-50	194.00
IUUC-Aly-006467	Arabidopsis lyrata	85.31	0.00e+00	1051.00
IUUC-Bta-012710	Bos taurus	34.07	6.00e-47	181.00
IUUC-Cfa-021096	Canis familiaris	33.33	1.00e-46	181.00
IUUC-Cre-022645	Chlamydomonas reinhardtii	35.81	7.00e-79	287.00
IUUC-Csa-023951	Chlorocebus sabaeus	32.88	6.00e-46	178.00
IUUC-Dse-031392	Dothistroma septosporum	34.31	3.00e-10	58.20
IUUC-Ete-032375	Echinops telfairi	27.15	5.00e-10	59.30
IUUC-Eca-033266	Equus caballus	34.73	5.00e-47	182.00
IUUC-Fca-035570	Felis catus	34.97	5.00e-43	168.00
IUUC-Fal-037550	Ficedula albicollis	36.23	2.00e-50	193.00
IUUC-Ggr-039874	Gaeumannomyces graminis	34.21	2.00e-10	60.10
IUUC-Lch-050162	Latimeria chalumnae	35.29	5.00e-48	185.00
IUUC-Loc-051806	Lepisosteus oculatus	35.29	9.00e-49	187.00
IUUC-Laf-053529	Loxodonta africana	32.64	2.00e-47	183.00
IUUC-Mpo-057318	Magnaporthe poae	35.66	1.00e-09	57.40
IUUC-Mvi-060378	Microbotryum violaceum	51.90	4.00e-33	135.00
IUUC-Mmr-060646	Microcebus murinus	33.33	9.00e-47	181.00
IUUC-Mpu-065830	Mustela putorius furo	33.42	1.00e-47	182.00
IUUC-Ncr-068942	Neurospora crassa	30.41	2.00e-07	49.70
IUUC-Nle-069901	Nomascus leucogenys	32.64	9.00e-46	177.00
IUUC-Opr-070813	Ochotona princeps	54.10	6.00e-11	62.00
IUUC-Ocu-074748	Oryctolagus cuniculus	33.50	5.00e-47	182.00
IUUC-Oga-088218	Otolemur garnettii	34.06	1.00e-46	180.00
IUUC-Oar-090189	Ovis aries	33.16	7.00e-47	181.00
IUUC-Psi-093033	Pelodiscus sinensis	31.90	2.00e-47	183.00
IUUC-Pca-100531	Procavia capensis	32.99	5.00e-47	182.00
IUUC-Pva-102266	Pteropus vampyrus	32.80	6.00e-47	181.00
IUUC-Pgr-103644	Puccinia graminis	52.74	3.00e-37	149.00
IUUC-Ptt-103867	Puccinia triticina	53.21	4.00e-41	162.00
IUUC-Ssl-108645	Sclerotinia sclerotiorum	39.06	6.00e-05	42.70
IUUC-Sar-113546	Sorex araneus	47.20	1.00e-25	111.00
IUUC-Tsy-119249	Tarsius syrichta	31.66	8.00e-46	178.00
IUUC-Tni-119843	Tetraodon nigroviridis	36.41	3.00e-51	195.00
IUUC-Tbe-127823	Tupaia belangeri	32.51	2.00e-39	157.00
IUUC-Vda-129727	Verticillium dahliae	30.06	2.00e-11	63.20
IUUC-Vpa-130073	Vicugna pacos	32.90	4.00e-47	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence