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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108308
UUCD1 version UUC-ScP-00114
Ensembl Protein ID SPBC17D11.02c.1:pep
UniProt Accession O74757; HRD1_SCHPO
Genbank Protein ID CAA21073.1
Protein Name ERAD-associated E3 ubiquitin-protein ligase hrd1; RING-type E3 ubiquitin transferase hrd1
Genbank Nucleotide ID CU329671
Gene Name hrd1; SPBC17D11.02c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC17D11.02c SPBC17D11.02c.1 SPBC17D11.02c.1:pep
Annotation
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.10e-10 37.4 292 351
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf.....................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                     ++ p+ lpCgH+ h++Cl +w        ++++CP+Cr
   Q: 292  CTICREEMfhpdhppentdemeplprgldMT-PKRLPCGHILHFHCLRNW------LERQQTCPICR 351
           9***999967666666655544444444333.999***************......**********8 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity). Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1.
 E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity). Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1.
Protein Sequence
(Fasta)
MKFILYVLAS LVLFGLSVLL SLYSSANVYS ATVMISQSPV HITIGLNVCL CLFFAIANAL 60
KTLLFGSLQT FELELLYEQF WITLTEIMLA ITVFREAISI SFFMLLSTLM FARVFHSICS 120
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Protein Fasta Sequence


>IUUC-Spo-108308|E3,RING|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
CGTGACATCT TGACGTTTCC CCATATTGAC GGACAACACC AAATAATTTA ATAATATGAA 60
GTTTATACTA TATGTGTTAG TAAGTTTTAA TTATGTTTTC CAGTTAATCT AATCTTGTAT 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108308|E3,RING|Schizosaccharomyces pombe
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012284--6PGD_dom_3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
SMART

SM00184--RING
Gene Ontology

GO:0005938--C:cell cortex
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG spo:SPBC17D11.02c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000344 Aegilops tauschii 29.12 2.00e-30 124.00
IUUC-Aml-001539 Ailuropoda melanoleuca 29.71 1.00e-38 152.00
IUUC-Atr-002892 Amborella trichopoda 32.80 2.00e-47 181.00
IUUC-Apl-003404 Anas platyrhynchos 22.91 5.00e-20 90.50
IUUC-Aca-004799 Anolis carolinensis 29.38 2.00e-38 151.00
IUUC-Aly-006352 Arabidopsis lyrata 33.93 2.00e-44 171.00
IUUC-Ath-006773 Arabidopsis thaliana 33.43 2.00e-44 171.00
IUUC-Ago-007894 Ashbya gossypii 25.77 1.00e-21 96.30
IUUC-Acl-008041 Aspergillus clavatus 32.38 4.00e-50 191.00
IUUC-Afl-008427 Aspergillus flavus 43.79 1.00e-34 139.00
IUUC-Afu-009023 Aspergillus fumigatus 31.17 1.00e-51 196.00
IUUC-Ani-009133 Aspergillus nidulans 32.52 3.00e-53 201.00
IUUC-Ang-009612 Aspergillus niger 35.21 2.00e-49 188.00
IUUC-Aor-010045 Aspergillus oryzae 43.79 9.00e-35 140.00
IUUC-Ate-010533 Aspergillus terreus 32.32 1.00e-53 202.00
IUUC-Ame-011083 Astyanax mexicanus 28.05 9.00e-36 142.00
IUUC-Bgr-012122 Blumeria graminis 37.57 9.00e-30 123.00
IUUC-Bta-013375 Bos taurus 29.71 3.00e-38 151.00
IUUC-Bci-013675 Botrytis cinerea 39.61 2.00e-26 112.00
IUUC-Bdi-015070 Brachypodium distachyon 31.83 5.00e-40 156.00
IUUC-Bol-015674 Brassica oleracea 34.44 2.00e-43 167.00
IUUC-Bra-017516 Brassica rapa 31.18 3.00e-41 160.00
IUUC-Cel-018422 Caenorhabditis elegans 30.30 1.00e-41 162.00
IUUC-Cja-019779 Callithrix jacchus 29.01 9.00e-34 136.00
IUUC-Cfa-020189 Canis familiaris 29.23 1.00e-40 159.00
IUUC-Cpo-022209 Cavia porcellus 29.71 1.00e-39 155.00
IUUC-Cre-022743 Chlamydomonas reinhardtii 30.21 4.00e-37 146.00
IUUC-Csa-023571 Chlorocebus sabaeus 29.71 5.00e-39 153.00
IUUC-Cho-024889 Choloepus hoffmanni 34.00 1.00e-23 102.00
IUUC-Cin-025215 Ciona intestinalis 23.94 6.00e-27 113.00
IUUC-Csv-026160 Ciona savignyi 27.02 4.00e-32 130.00
IUUC-Cne-027002 Cryptococcus neoformans 36.97 2.00e-66 245.00
IUUC-Cme-027285 Cyanidioschyzon merolae 31.41 8.00e-34 136.00
IUUC-Dre-027999 Danio rerio 27.96 1.00e-37 149.00
IUUC-Dno-029250 Dasypus novemcinctus 29.71 1.00e-38 152.00
IUUC-Dor-030718 Dipodomys ordii 30.62 5.00e-37 147.00
IUUC-Dse-031498 Dothistroma septosporum 37.89 3.00e-29 121.00
IUUC-Dme-031969 Drosophila melanogaster 30.18 3.00e-43 167.00
IUUC-Ete-032962 Echinops telfairi 22.33 3.00e-17 81.30
IUUC-Eca-033258 Equus caballus 29.71 8.00e-39 152.00
IUUC-Fca-035980 Felis catus 29.71 8.00e-40 156.00
IUUC-Fal-036758 Ficedula albicollis 22.65 3.00e-17 81.30
IUUC-Fox-037902 Fusarium oxysporum 37.82 2.00e-29 122.00
IUUC-Fso-038418 Fusarium solani 38.41 9.00e-30 123.00
IUUC-Gmo-039288 Gadus morhua 28.45 3.00e-35 141.00
IUUC-Ggr-040076 Gaeumannomyces graminis 30.48 8.00e-50 190.00
IUUC-Gga-040575 Gallus gallus 23.78 4.00e-21 94.40
IUUC-Gac-042347 Gasterosteus aculeatus 28.35 3.00e-38 150.00
IUUC-Gma-044123 Glycine max 30.88 5.00e-45 173.00
IUUC-Ggo-044858 Gorilla gorilla 29.71 1.00e-38 152.00
IUUC-Hsa-046412 Homo sapiens 29.71 1.00e-38 152.00
IUUC-Hvu-047279 Hordeum vulgare 32.44 9.00e-40 155.00
IUUC-Itr-048924 Ictidomys tridecemlineatus 29.71 1.00e-38 152.00
IUUC-Kpa-049117 Komagataella pastoris 23.97 1.00e-22 99.00
IUUC-Lch-050491 Latimeria chalumnae 22.96 3.00e-21 95.10
IUUC-Lpe-051229 Leersia perrieri 35.71 9.00e-14 69.30
IUUC-Loc-052843 Lepisosteus oculatus 31.02 4.00e-25 106.00
IUUC-Lma-052997 Leptosphaeria maculans 42.95 1.00e-33 136.00
IUUC-Laf-053482 Loxodonta africana 29.71 1.00e-38 152.00
IUUC-Mcc-055075 Macaca mulatta 29.71 1.00e-38 152.00
IUUC-Meu-056683 Macropus eugenii 28.93 7.00e-30 123.00
IUUC-Mor-057082 Magnaporthe oryzae 31.35 5.00e-51 194.00
IUUC-Mpo-057573 Magnaporthe poae 30.31 1.00e-43 169.00
IUUC-Mtr-058639 Medicago truncatula 31.66 8.00e-47 179.00
IUUC-Mla-059168 Melampsora laricipopulina 33.61 2.00e-55 208.00
IUUC-Mga-059937 Meleagris gallopavo 23.94 2.00e-21 95.50
IUUC-Mvi-060515 Microbotryum violaceum 32.97 3.00e-43 168.00
IUUC-Mmr-060922 Microcebus murinus 29.23 2.00e-39 154.00
IUUC-Mdo-062491 Monodelphis domestica 28.74 1.00e-35 142.00
IUUC-Mmu-063770 Mus musculus 29.71 5.00e-39 153.00
IUUC-Mac-064789 Musa acuminata 30.92 4.00e-50 190.00
IUUC-Mpu-066107 Mustela putorius furo 29.69 3.00e-38 150.00
IUUC-Mlu-067918 Myotis lucifugus 28.61 4.00e-36 144.00
IUUC-Nfi-068389 Neosartorya fischeri 31.27 4.00e-50 191.00
IUUC-Ncr-068742 Neurospora crassa 29.48 8.00e-41 160.00
IUUC-Nle-069139 Nomascus leucogenys 29.71 1.00e-38 152.00
IUUC-Opr-070898 Ochotona princeps 30.80 6.00e-28 117.00
IUUC-Ont-071991 Oreochromis niloticus 28.41 1.00e-37 149.00
IUUC-Oan-073717 Ornithorhynchus anatinus 22.88 6.00e-21 93.60
IUUC-Ocu-074065 Oryctolagus cuniculus 29.43 7.00e-38 149.00
IUUC-Oba-075221 Oryza barthii 31.19 1.00e-41 161.00
IUUC-Obr-076914 Oryza brachyantha 29.57 2.00e-40 157.00
IUUC-Ogu-078124 Oryza glumaepatula 31.19 2.00e-41 161.00
IUUC-Oin-080013 Oryza indica 31.19 6.00e-40 156.00
IUUC-Olo-080247 Oryza longistaminata 31.19 7.00e-41 159.00
IUUC-Ome-081769 Oryza meridionalis 31.21 4.00e-42 163.00
IUUC-Oni-082946 Oryza nivara 31.19 1.00e-41 162.00
IUUC-Opu-083268 Oryza punctata 27.87 4.00e-28 117.00
IUUC-Oru-085114 Oryza rufipogon 31.19 2.00e-41 161.00
IUUC-Osa-085829 Oryza sativa 31.52 7.00e-42 162.00
IUUC-Ola-087449 Oryzias latipes 28.57 1.00e-35 142.00
IUUC-Olu-087894 Ostreococcus lucimarinus 33.54 2.00e-42 163.00
IUUC-Oga-089036 Otolemur garnettii 29.71 4.00e-39 154.00
IUUC-Oar-089715 Ovis aries 29.71 7.00e-39 153.00
IUUC-Ptr-091000 Pan troglodytes 29.71 2.00e-38 151.00
IUUC-Pan-092187 Papio anubis 29.71 3.00e-39 154.00
IUUC-Psi-093377 Pelodiscus sinensis 29.09 1.00e-35 142.00
IUUC-Pma-094759 Petromyzon marinus 34.21 5.00e-26 110.00
IUUC-Pno-094883 Phaeosphaeria nodorum 30.05 2.00e-42 165.00
IUUC-Ppa-095684 Physcomitrella patens 33.73 3.00e-43 167.00
IUUC-Pfo-096861 Poecilia formosa 28.01 1.00e-36 145.00
IUUC-Pab-098030 Pongo abelii 29.71 1.00e-38 152.00
IUUC-Pop-099245 Populus trichocarpa 31.66 1.00e-46 178.00
IUUC-Pca-100191 Procavia capensis 29.71 1.00e-37 149.00
IUUC-Ppe-101829 Prunus persica 31.72 2.00e-46 178.00
IUUC-Pva-102689 Pteropus vampyrus 29.71 5.00e-38 150.00
IUUC-Pgr-103286 Puccinia graminis 35.07 5.00e-55 207.00
IUUC-Ptt-103919 Puccinia triticina 33.51 1.00e-52 198.00
IUUC-Pte-104372 Pyrenophora teres 30.52 7.00e-49 186.00
IUUC-Pyt-104456 Pyrenophora triticirepentis 30.42 3.00e-47 181.00
IUUC-Rno-105723 Rattus norvegicus 29.71 1.00e-38 152.00
IUUC-Sce-106348 Saccharomyces cerevisiae 26.00 2.00e-25 108.00
IUUC-Sha-107300 Sarcophilus harrisii 28.93 5.00e-31 127.00
IUUC-Sja-107685 Schizosaccharomyces japonicus 59.23 3.00e-122 429.00
IUUC-Ssl-108558 Sclerotinia sclerotiorum 39.61 8.00e-27 113.00
IUUC-Smo-109123 Selaginella moellendorffii 34.87 4.00e-47 179.00
IUUC-Sit-110276 Setaria italica 32.42 5.00e-42 163.00
IUUC-Sly-111819 Solanum lycopersicum 33.76 4.00e-45 173.00
IUUC-Stu-112048 Solanum tuberosum 29.86 2.00e-44 171.00
IUUC-Sar-113397 Sorex araneus 26.63 2.00e-17 82.00
IUUC-Sbi-114027 Sorghum bicolor 31.83 7.00e-49 186.00
IUUC-Sre-115212 Sporisorium reilianum 32.54 2.00e-42 165.00
IUUC-Ssc-116323 Sus scrofa 29.71 2.00e-38 151.00
IUUC-Tgu-116717 Taeniopygia guttata 22.29 3.00e-19 88.20
IUUC-Tru-118045 Takifugu rubripes 28.77 8.00e-39 153.00
IUUC-Tsy-119442 Tarsius syrichta 23.01 1.00e-20 92.40
IUUC-Tni-120106 Tetraodon nigroviridis 28.94 2.00e-28 118.00
IUUC-Tca-121462 Theobroma cacao 31.18 2.00e-45 174.00
IUUC-Tre-122204 Trichoderma reesei 36.99 3.00e-29 121.00
IUUC-Tvi-122550 Trichoderma virens 38.16 1.00e-27 116.00
IUUC-Tae-124673 Triticum aestivum 31.60 2.00e-40 157.00
IUUC-Tur-126538 Triticum urartu 29.03 3.00e-30 124.00
IUUC-Tme-127197 Tuber melanosporum 33.33 5.00e-49 187.00
IUUC-Tbe-127385 Tupaia belangeri 34.67 2.00e-24 105.00
IUUC-Ttr-128795 Tursiops truncatus 29.71 1.00e-38 152.00
IUUC-Uma-129401 Ustilago maydis 31.06 8.00e-28 116.00
IUUC-Vda-129968 Verticillium dahliae 38.67 2.00e-29 122.00
IUUC-Vpa-130483 Vicugna pacos 21.30 9.00e-16 76.30
IUUC-Vvi-130944 Vitis vinifera 34.12 1.00e-45 175.00
IUUC-Xtr-131884 Xenopus tropicalis 28.45 2.00e-37 148.00
IUUC-Xma-133488 Xiphophorus maculatus 27.87 5.00e-36 144.00
IUUC-Yli-134552 Yarrowia lipolytica 25.22 7.00e-28 116.00
IUUC-Zma-135530 Zea mays 31.58 5.00e-45 173.00
Created Date 25-Jun-2017

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