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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046898
UUCD1 version UUC-HoS-01158
Ensembl Protein ID ENSP00000228820.4
UniProt Accession Q9NR21; B4DRQ0; Q68DS1; Q8N5Y9; PAR11_HUMAN
Genbank Protein ID AAF91391.1; BAG61362.1; CAH18149.1; EAW88853.1; AAH17569.1; AAH31073.1
Protein Name Poly [ADP-ribose] polymerase 11; ADP-ribosyltransferase diphtheria toxin-like 11
Genbank Nucleotide ID AF263540; AK299372; CR749294; AC005842; BC017569; BC031073
Gene Name PARP11; C12orf6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111224.13 ENST00000416739.5 ENSP00000392392.1
ENSG00000111224.13 ENST00000427057.6 ENSP00000397058.2
ENSG00000111224.13 ENST00000458162.6 ENSP00000399665.2
ENSG00000111224.13 ENST00000228820.8 ENSP00000228820.4
ENSG00000111224.13 ENST00000453942.2 ENSP00000395062.2
ENSG00000111224.13 ENST00000450737.2 ENSP00000387481.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
PhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/Other DUB/Other 19615732
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).
 Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).
Protein Sequence
(Fasta)
MWEANPEMFH KAEELFSKTT NNEVDDMDTS DTQWGWFYLA ECGKWHMFQP DTNSQCSVSS 60
EDIEKSFKTN PCGSISFTTS KFSYKIDFAE MKQMNLTTGK QRLIKRAPFS ISAFSYICEN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046898|DUB,DUB/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGACAGAT CTGACTGGCC AACGTCGGGC GGAAGTCGGG AGGTTGGGTG GTCTGTAAAC 60
GCTGGCTTGT GACAGGGAGG GGGAGGAGGA AGGCCTTCGT AAAGGTTGCA TCTCCGTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046898|DUB,DUB/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0013--ADP-ribosylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0328--Glycosyltransferase
KW-0509--mRNA transport
KW-0520--NAD
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0811--Translocation
KW-0813--Transport
Interpro

IPR012317--Poly(ADP-ribose)pol_cat_dom
IPR004170--WWE-dom
PROSITE

PS51059--PARP_CATALYTIC
PS50918--WWE
Pfam

PF00644--PARP
PF02825--WWE
Gene Ontology

GO:0005635--C:nuclear envelope
GO:0005643--C:nuclear pore
GO:0003950--F:NAD+ ADP-ribosyltransferase activity
GO:0030154--P:cell differentiation
GO:0051028--P:mRNA transport
GO:0006998--P:nuclear envelope organization
GO:0015031--P:protein transport
GO:0007283--P:spermatogenesis
KEGG hsa:57097
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002292 Ailuropoda melanoleuca 92.31 0.00e+00 642.00
IUUC-Apl-003207 Anas platyrhynchos 74.21 6.00e-152 530.00
IUUC-Aca-004986 Anolis carolinensis 71.52 7.00e-140 489.00
IUUC-Aly-006570 Arabidopsis lyrata 23.65 2.00e-04 41.20
IUUC-Ath-006833 Arabidopsis thaliana 24.86 5.00e-05 42.70
IUUC-Ame-010744 Astyanax mexicanus 51.80 3.00e-85 308.00
IUUC-Bta-013000 Bos taurus 88.98 0.00e+00 635.00
IUUC-Bdi-014530 Brachypodium distachyon 25.76 2.00e-04 41.60
IUUC-Bol-015256 Brassica oleracea 25.90 1.00e-03 38.10
IUUC-Bra-017321 Brassica rapa 26.51 7.00e-04 38.90
IUUC-Cja-019771 Callithrix jacchus 98.22 0.00e+00 679.00
IUUC-Cfa-020993 Canis familiaris 93.49 0.00e+00 676.00
IUUC-Cpo-021512 Cavia porcellus 92.75 0.00e+00 630.00
IUUC-Csa-023879 Chlorocebus sabaeus 98.82 0.00e+00 708.00
IUUC-Cho-024502 Choloepus hoffmanni 93.94 8.00e-179 619.00
IUUC-Dre-027641 Danio rerio 38.51 9.00e-64 236.00
IUUC-Dno-029697 Dasypus novemcinctus 84.94 2.00e-170 591.00
IUUC-Ete-032790 Echinops telfairi 97.28 9.00e-86 310.00
IUUC-Eca-034111 Equus caballus 95.47 0.00e+00 648.00
IUUC-Eeu-035016 Erinaceus europaeus 74.92 1.00e-133 469.00
IUUC-Fca-036573 Felis catus 95.27 0.00e+00 688.00
IUUC-Fal-036975 Ficedula albicollis 79.45 4.00e-160 556.00
IUUC-Gmo-039025 Gadus morhua 56.01 1.00e-108 385.00
IUUC-Gga-040569 Gallus gallus 79.82 2.00e-164 572.00
IUUC-Gac-041472 Gasterosteus aculeatus 54.98 9.00e-104 370.00
IUUC-Ggo-045088 Gorilla gorilla 99.41 0.00e+00 686.00
IUUC-Itr-049047 Ictidomys tridecemlineatus 96.37 3.00e-180 624.00
IUUC-Lch-049457 Latimeria chalumnae 74.10 2.00e-154 538.00
IUUC-Loc-051755 Lepisosteus oculatus 59.18 3.00e-116 411.00
IUUC-Laf-053383 Loxodonta africana 96.37 0.00e+00 654.00
IUUC-Mcc-055141 Macaca mulatta 99.70 0.00e+00 686.00
IUUC-Meu-056178 Macropus eugenii 80.42 2.00e-159 554.00
IUUC-Mmr-061650 Microcebus murinus 96.75 0.00e+00 665.00
IUUC-Mdo-061843 Monodelphis domestica 89.16 0.00e+00 632.00
IUUC-Mmu-063312 Mus musculus 94.86 3.00e-177 613.00
IUUC-Mac-065114 Musa acuminata 23.04 4.00e-04 40.00
IUUC-Mpu-066436 Mustela putorius furo 94.38 0.00e+00 682.00
IUUC-Mlu-067990 Myotis lucifugus 89.55 0.00e+00 635.00
IUUC-Nle-070071 Nomascus leucogenys 99.11 0.00e+00 711.00
IUUC-Opr-070459 Ochotona princeps 93.35 1.00e-175 608.00
IUUC-Ont-072362 Oreochromis niloticus 57.38 1.00e-105 376.00
IUUC-Ocu-074786 Oryctolagus cuniculus 96.45 0.00e+00 640.00
IUUC-Ogu-078498 Oryza glumaepatula 24.39 4.00e-03 37.00
IUUC-Oin-079090 Oryza indica 24.39 4.00e-03 36.60
IUUC-Oni-082246 Oryza nivara 24.39 3.00e-03 37.00
IUUC-Opu-084003 Oryza punctata 24.39 6.00e-04 39.70
IUUC-Oru-084978 Oryza rufipogon 24.39 3.00e-03 37.00
IUUC-Osa-086125 Oryza sativa 24.39 3.00e-03 37.00
IUUC-Ola-086821 Oryzias latipes 55.95 4.00e-103 367.00
IUUC-Oga-088690 Otolemur garnettii 97.04 0.00e+00 667.00
IUUC-Oar-090433 Ovis aries 93.37 0.00e+00 641.00
IUUC-Ptr-091671 Pan troglodytes 99.41 0.00e+00 684.00
IUUC-Pan-092070 Papio anubis 99.70 0.00e+00 686.00
IUUC-Psi-093329 Pelodiscus sinensis 83.08 1.00e-164 572.00
IUUC-Pfo-096179 Poecilia formosa 55.90 1.00e-108 386.00
IUUC-Pab-097742 Pongo abelii 92.60 0.00e+00 651.00
IUUC-Pop-098936 Populus trichocarpa 26.45 2.00e-04 40.00
IUUC-Pca-100658 Procavia capensis 94.26 0.00e+00 643.00
IUUC-Pva-103056 Pteropus vampyrus 77.64 1.00e-149 522.00
IUUC-Rno-105589 Rattus norvegicus 93.75 0.00e+00 642.00
IUUC-Sha-107203 Sarcophilus harrisii 89.16 0.00e+00 631.00
IUUC-Sit-110659 Setaria italica 37.50 3.00e-04 40.40
IUUC-Sly-111820 Solanum lycopersicum 23.14 2.00e-04 40.40
IUUC-Sar-113524 Sorex araneus 93.35 0.00e+00 633.00
IUUC-Sbi-113865 Sorghum bicolor 25.30 6.00e-03 37.00
IUUC-Ssc-115603 Sus scrofa 95.47 0.00e+00 648.00
IUUC-Tgu-116473 Taeniopygia guttata 78.83 3.00e-159 554.00
IUUC-Tru-117592 Takifugu rubripes 57.05 9.00e-105 373.00
IUUC-Tsy-118936 Tarsius syrichta 96.36 0.00e+00 645.00
IUUC-Tni-120472 Tetraodon nigroviridis 56.68 6.00e-105 373.00
IUUC-Tbe-127303 Tupaia belangeri 96.07 0.00e+00 650.00
IUUC-Ttr-128870 Tursiops truncatus 93.35 0.00e+00 639.00
IUUC-Vpa-130087 Vicugna pacos 97.96 1.00e-86 312.00
IUUC-Xtr-132149 Xenopus tropicalis 67.10 6.00e-120 423.00
Created Date 25-Jun-2017

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