iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091111

Ensembl Protein ID

ENSPTRP00000024917.2

UniProt Accession

H2QLU5; H2QLU5_PANTR

Genbank Protein ID

JAA02832.1; JAA16655.1; JAA32246.1; JAA39847.1

Protein Name

Protein kinase C and casein kinase substrate in neurons 2

Genbank Nucleotide ID

AACZ03125895; GABF01005490; GABD01000854; GABE01004892

Gene Name

PACSIN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014465.4	ENSPTRT00000027030.2	ENSPTRP00000024917.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.40e-16	59.4	430	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydye+q+ deL++k+Gd ++ + ++e ++gW+kg + ++g+ Gl P+n+ve ++
   Q: 430  RVRALYDYEGQEHDELSFKAGDELTKM-EDEDEQGWCKG-RLDNGQVGLYPANYVEAIQ 486
           799***********************9.9**********.59*************9885 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTCCCACT GGGCAGGTGC CTCTGACGGA GAGGAGGCGT CGTCGGGAAG TATGTGGCCG 60
TGGCTGCTCT GGCATGATCC TGAAGACTGA CACGAAGGGG AATGGAGCCG CACAGAGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR028521--PACSIN2
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005901--C:caveola
GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005925--C:focal adhesion
GO:0016607--C:nuclear speck
GO:0055038--C:recycling endosome membrane
GO:0016301--F:kinase activity
GO:0070300--F:phosphatidic acid binding
GO:0030036--P:actin cytoskeleton organization
GO:0070836--P:caveola assembly
GO:0072584--P:caveolin-mediated endocytosis
GO:0048858--P:cell projection morphogenesis
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0036010--P:protein localization to endosome
GO:0030100--P:regulation of endocytosis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001887	Ailuropoda melanoleuca	93.42	0.00e+00	857.00
IUUC-Apl-003574	Anas platyrhynchos	87.27	0.00e+00	773.00
IUUC-Aca-004251	Anolis carolinensis	80.62	0.00e+00	742.00
IUUC-Ame-011756	Astyanax mexicanus	66.21	0.00e+00	663.00
IUUC-Bta-013193	Bos taurus	89.92	0.00e+00	800.00
IUUC-Cel-018168	Caenorhabditis elegans	31.72	1.00e-60	227.00
IUUC-Cja-018756	Callithrix jacchus	96.91	0.00e+00	862.00
IUUC-Cfa-020545	Canis familiaris	93.83	0.00e+00	889.00
IUUC-Cpo-022000	Cavia porcellus	88.89	0.00e+00	889.00
IUUC-Csa-024030	Chlorocebus sabaeus	97.98	0.00e+00	790.00
IUUC-Cin-025707	Ciona intestinalis	42.74	2.00e-105	375.00
IUUC-Csv-026244	Ciona savignyi	42.11	2.00e-54	205.00
IUUC-Dre-028104	Danio rerio	62.80	4.00e-161	561.00
IUUC-Dno-029429	Dasypus novemcinctus	92.51	0.00e+00	783.00
IUUC-Dor-030122	Dipodomys ordii	86.83	0.00e+00	781.00
IUUC-Dme-032120	Drosophila melanogaster	42.86	1.00e-104	373.00
IUUC-Eca-033367	Equus caballus	91.36	0.00e+00	833.00
IUUC-Eeu-034821	Erinaceus europaeus	76.54	0.00e+00	667.00
IUUC-Fca-036079	Felis catus	94.02	0.00e+00	857.00
IUUC-Fal-036682	Ficedula albicollis	87.23	0.00e+00	770.00
IUUC-Gmo-039681	Gadus morhua	64.29	4.00e-155	541.00
IUUC-Gga-040717	Gallus gallus	87.45	0.00e+00	773.00
IUUC-Gac-042262	Gasterosteus aculeatus	63.73	1.00e-168	585.00
IUUC-Ggo-044841	Gorilla gorilla	99.18	0.00e+00	855.00
IUUC-Hsa-046411	Homo sapiens	99.18	0.00e+00	854.00
IUUC-Itr-049063	Ictidomys tridecemlineatus	94.65	0.00e+00	835.00
IUUC-Lch-050070	Latimeria chalumnae	64.49	6.00e-178	617.00
IUUC-Loc-051975	Lepisosteus oculatus	70.23	0.00e+00	682.00
IUUC-Laf-053839	Loxodonta africana	89.56	0.00e+00	811.00
IUUC-Mcc-055783	Macaca mulatta	98.56	0.00e+00	850.00
IUUC-Meu-056348	Macropus eugenii	64.27	1.00e-155	542.00
IUUC-Mga-060087	Meleagris gallopavo	81.91	0.00e+00	707.00
IUUC-Mmr-060827	Microcebus murinus	94.86	0.00e+00	870.00
IUUC-Mmu-064109	Mus musculus	93.62	0.00e+00	858.00
IUUC-Mpu-066591	Mustela putorius furo	93.83	0.00e+00	863.00
IUUC-Mlu-067826	Myotis lucifugus	93.00	0.00e+00	855.00
IUUC-Nle-069797	Nomascus leucogenys	98.97	0.00e+00	853.00
IUUC-Ont-072188	Oreochromis niloticus	61.48	3.00e-163	568.00
IUUC-Oan-073076	Ornithorhynchus anatinus	83.77	3.00e-152	531.00
IUUC-Ocu-074425	Oryctolagus cuniculus	93.62	0.00e+00	837.00
IUUC-Ola-087556	Oryzias latipes	64.65	5.00e-161	560.00
IUUC-Oga-089009	Otolemur garnettii	85.46	0.00e+00	784.00
IUUC-Oar-089806	Ovis aries	90.33	0.00e+00	803.00
IUUC-Pan-091749	Papio anubis	95.85	0.00e+00	835.00
IUUC-Psi-093704	Pelodiscus sinensis	86.81	0.00e+00	785.00
IUUC-Pfo-096680	Poecilia formosa	62.38	3.00e-165	574.00
IUUC-Pab-098584	Pongo abelii	99.05	3.00e-168	583.00
IUUC-Pca-100881	Procavia capensis	63.24	1.00e-151	529.00
IUUC-Pva-102649	Pteropus vampyrus	92.80	0.00e+00	833.00
IUUC-Rno-105431	Rattus norvegicus	93.03	0.00e+00	872.00
IUUC-Sha-106641	Sarcophilus harrisii	89.06	0.00e+00	802.00
IUUC-Sar-113461	Sorex araneus	81.89	0.00e+00	725.00
IUUC-Ssc-115349	Sus scrofa	93.61	0.00e+00	830.00
IUUC-Tgu-116876	Taeniopygia guttata	87.45	0.00e+00	771.00
IUUC-Tru-118306	Takifugu rubripes	66.60	6.00e-173	600.00
IUUC-Tsy-118901	Tarsius syrichta	83.58	3.00e-150	525.00
IUUC-Tni-120120	Tetraodon nigroviridis	67.41	5.00e-177	613.00
IUUC-Ttr-129069	Tursiops truncatus	64.16	8.00e-148	516.00
IUUC-Xtr-132925	Xenopus tropicalis	80.08	0.00e+00	736.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence