iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004010

Ensembl Protein ID

ENSAPLP00000015328.1

UniProt Accession

U3J751; U3J751_ANAPL

Genbank Protein ID

ENSAPLP00000015328

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01142003

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000015400.1	ENSAPLT00000016123.1	ENSAPLP00000015328.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-60	203.1	151	647

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G+kN+gNtC++ +v+Q+L+++pe+r+l+l      +  e+++ +   +++ +++++lq lf+ ++ +++k v+p++ l+ l+++ ++ 
   Q: 151  VGMKNIGNTCWFSAVIQSLFQLPEFRRLVLGyslpqSVLESCRSR-TGKRNIAFMQELQCLFALMLGTRRKFVDPSAALELLRDAFRS- 237
           6******************************97775555556544.589999*******************************99998. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                 + + +++++  k+++++++lF g++ ++ +    +n+ s+ e+f +++
   Q: 238  AEEQQQDVSEFTHKLLDWLEDAFQL----------------AVNVKNRSPADKSENPMVQLFYGTFLTEGVH--EGNTFSKIETFGQYP 308
           799********************22................222356789999**************99887..6788899******** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e+++e        +++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+++ ++
   Q: 309  LQVNGYR-----NLNECLEGAMVEGEMDEET------ATQSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQTIYMD 386
           *******.....9*****9999888888755......455555566679************************************9999 PP
   S: 263  p..fcts.................................................................................. 267
           +  +c++                                                                                  
   Q: 387  RylYCSKeliqmkreemkrlkermtilqqklesrymkygsgparfplpdmlqyvlefiatksavpvspecvssaqdsettvlqsqagsc 475
           85577778888888888888888777777777777777777777777777777777777777777777777776666666666666666 PP
   S: 268  ..................peekqke................................................................ 274
                             +     e                                                                
   Q: 476  ildmlsqpnsilerkdteT-----Edaavllansspqkkldvplqpsgspaeiserpaphevseeemnlvrtclqrwrneieqdvqdlk 559
           6666666666665555550.....05555555555555666666666666677777777777777777888888888888888888889 PP
   S: 275  ....................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                               ++ Y L+av+vH+G+++ GHY+ay++++ +k Wl+++D +Vte+++ee ++++      ++aY+l+Y 
   Q: 560  esitrvnlsieqmycdpllqQVPYHLHAVLVHEGQANAGHYWAYIYDQPRKsWLKYNDISVTESSWEELERDSFggsknASAYCLMYI 647
           99999999999999999999***************************77667*******************87799***********6 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

QMLLNQLKEI TGIQDSAFLQ AALKAANGDL MEAVTFLTEE HAQEPAQDTA AAEPSAWEGS 60
AVGKQLPQNG AALNPNNKDD LHTVVFRQLE SPKEFLRLFV RWCFTEVFMF CDRPQEVHSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGATGCTTT TAAACCAACT GAAAGAGATA ACAGGAATTC AGGATTCAGC TTTCCTCCAA 60
GCAGCTCTGA AGGTTTGTAT ATGTTGTTAA GACCTCTCAT TTTGTCCCCA AAATCAGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	69.83	0.00e+00	1471.00
IUUC-Aca-004741	Anolis carolinensis	60.28	0.00e+00	862.00
IUUC-Ani-009503	Aspergillus nidulans	34.00	2.00e-11	65.10
IUUC-Bta-013377	Bos taurus	68.42	0.00e+00	1417.00
IUUC-Cja-019977	Callithrix jacchus	69.81	0.00e+00	1457.00
IUUC-Cfa-020378	Canis familiaris	64.68	0.00e+00	1387.00
IUUC-Cpo-021817	Cavia porcellus	68.93	0.00e+00	1445.00
IUUC-Csa-023446	Chlorocebus sabaeus	66.02	0.00e+00	946.00
IUUC-Cho-024717	Choloepus hoffmanni	61.96	0.00e+00	901.00
IUUC-Dno-029559	Dasypus novemcinctus	68.10	0.00e+00	1125.00
IUUC-Dor-030955	Dipodomys ordii	66.94	0.00e+00	1386.00
IUUC-Ete-032828	Echinops telfairi	64.10	0.00e+00	888.00
IUUC-Eca-034300	Equus caballus	68.98	0.00e+00	1421.00
IUUC-Eeu-034458	Erinaceus europaeus	65.00	0.00e+00	1238.00
IUUC-Fca-035753	Felis catus	69.28	0.00e+00	1454.00
IUUC-Fal-037062	Ficedula albicollis	79.48	0.00e+00	1137.00
IUUC-Gmo-039593	Gadus morhua	51.47	0.00e+00	1020.00
IUUC-Gga-040878	Gallus gallus	80.39	0.00e+00	1703.00
IUUC-Gac-041867	Gasterosteus aculeatus	52.49	0.00e+00	1066.00
IUUC-Ggo-045384	Gorilla gorilla	70.45	0.00e+00	1460.00
IUUC-Hsa-046277	Homo sapiens	70.36	0.00e+00	1457.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	63.60	0.00e+00	815.00
IUUC-Kpa-049349	Komagataella pastoris	34.38	2.00e-10	61.60
IUUC-Lch-049692	Latimeria chalumnae	63.55	0.00e+00	1326.00
IUUC-Laf-053808	Loxodonta africana	64.17	0.00e+00	1315.00
IUUC-Mcc-055473	Macaca mulatta	66.02	0.00e+00	946.00
IUUC-Meu-056416	Macropus eugenii	59.17	0.00e+00	1155.00
IUUC-Mga-060011	Meleagris gallopavo	83.07	0.00e+00	1786.00
IUUC-Mmr-060720	Microcebus murinus	68.05	0.00e+00	1387.00
IUUC-Mdo-061955	Monodelphis domestica	65.38	0.00e+00	1350.00
IUUC-Mmu-063870	Mus musculus	65.29	0.00e+00	1347.00
IUUC-Mpu-066454	Mustela putorius furo	65.16	0.00e+00	919.00
IUUC-Mlu-067487	Myotis lucifugus	66.14	0.00e+00	1357.00
IUUC-Nle-070044	Nomascus leucogenys	70.05	0.00e+00	1454.00
IUUC-Opr-070888	Ochotona princeps	77.26	3.00e-125	442.00
IUUC-Ocu-074523	Oryctolagus cuniculus	69.25	0.00e+00	1443.00
IUUC-Ola-086393	Oryzias latipes	52.53	0.00e+00	1070.00
IUUC-Oga-088618	Otolemur garnettii	69.07	0.00e+00	1434.00
IUUC-Oar-089848	Ovis aries	63.31	0.00e+00	1340.00
IUUC-Ptr-091630	Pan troglodytes	72.02	0.00e+00	1156.00
IUUC-Pan-092882	Papio anubis	65.72	3.00e-167	582.00
IUUC-Psi-093422	Pelodiscus sinensis	70.77	0.00e+00	1559.00
IUUC-Pma-094250	Petromyzon marinus	46.21	1.00e-63	236.00
IUUC-Pab-098337	Pongo abelii	70.32	0.00e+00	1456.00
IUUC-Pca-100901	Procavia capensis	74.15	0.00e+00	814.00
IUUC-Pva-102226	Pteropus vampyrus	65.61	0.00e+00	1245.00
IUUC-Pte-104300	Pyrenophora teres	21.09	4.00e-13	70.50
IUUC-Rno-105735	Rattus norvegicus	64.03	0.00e+00	1363.00
IUUC-Sha-107489	Sarcophilus harrisii	70.00	0.00e+00	1474.00
IUUC-Tgu-116609	Taeniopygia guttata	81.79	0.00e+00	1696.00
IUUC-Tru-117807	Takifugu rubripes	52.07	0.00e+00	1035.00
IUUC-Tsy-118971	Tarsius syrichta	67.93	0.00e+00	936.00
IUUC-Tni-119983	Tetraodon nigroviridis	51.58	0.00e+00	1050.00
IUUC-Ttr-128887	Tursiops truncatus	65.65	0.00e+00	1352.00
IUUC-Vpa-130614	Vicugna pacos	70.15	0.00e+00	1117.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence