iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	9.40e-09	35.5	28	65
UBD/SH3	1.20e-21	76.8	244	307

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++l+ l +MGF+r +a++aL+++ + +++aA+++L+++
   Q: 28   SALDLLLSMGFPRARAQKALASTgGRSVQAACDWLFSH 65
           68999*******************************97 PP

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++e++qv+y+y++qnddeL+l  Gd++++   e+++++egW++g++ ++g++Gl+Pen+++k++
   Q: 244  NHETLQVIYPYSPQNDDELELVPGDFIFMSpmEQTSTSEGWIYGTSLTTGCSGLLPENYITKAD 307
           6899*********************************************************987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAREELYSK VTPRRDRLQR PGTVRHGSAL DLLLSMGFPR ARAQKALAST GGRSVQAACD 60
WLFSHVGDPF LDDPLPREYV LYLRPTGPLA QKLSDFWQQS KQICGKNKAH NIFPHITLCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGGGCCT GCCCACAAGG CTGCTTTTCC TTTTTGATCC ATTCAAAAAT TACTCATTGC 60
AAATTCCCGG ACAGCTCAGG GAGGAGAAGC TGGGGGGGGC GGAGGACAGA GAAAGCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50002--SH3
PS50030--UBA

Pfam

PF00300--His_Phos_1
PF14604--SH3_9
PF00627--UBA

SMART

SM00326--SH3
SM00165--UBA

Gene Ontology

GO:0004725--F:protein tyrosine phosphatase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0045779--P:negative regulation of bone resorption
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0090331--P:negative regulation of platelet aggregation
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol

KEGG

rno:315579

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002126	Ailuropoda melanoleuca	95.43	0.00e+00	1252.00
IUUC-Apl-004080	Anas platyrhynchos	89.78	0.00e+00	1099.00
IUUC-Aca-004828	Anolis carolinensis	84.08	0.00e+00	1038.00
IUUC-Ame-011030	Astyanax mexicanus	73.99	0.00e+00	823.00
IUUC-Bta-012370	Bos taurus	96.81	0.00e+00	1188.00
IUUC-Bci-013728	Botrytis cinerea	28.14	4.00e-10	58.50
IUUC-Cel-018530	Caenorhabditis elegans	39.30	9.00e-51	193.00
IUUC-Cja-018758	Callithrix jacchus	96.55	0.00e+00	1253.00
IUUC-Cfa-020544	Canis familiaris	95.93	0.00e+00	1013.00
IUUC-Cpo-022044	Cavia porcellus	96.47	0.00e+00	1184.00
IUUC-Csa-024169	Chlorocebus sabaeus	96.55	0.00e+00	1251.00
IUUC-Cho-024498	Choloepus hoffmanni	79.50	0.00e+00	898.00
IUUC-Cin-025372	Ciona intestinalis	41.60	3.00e-58	219.00
IUUC-Csv-026379	Ciona savignyi	43.96	1.00e-74	273.00
IUUC-Cgl-026592	Colletotrichum gloeosporioides	29.59	2.00e-09	56.20
IUUC-Dre-027539	Danio rerio	73.14	0.00e+00	997.00
IUUC-Dno-029808	Dasypus novemcinctus	95.05	0.00e+00	744.00
IUUC-Dor-030582	Dipodomys ordii	79.78	0.00e+00	999.00
IUUC-Dme-032201	Drosophila melanogaster	38.89	1.00e-65	244.00
IUUC-Ete-032740	Echinops telfairi	76.80	0.00e+00	1004.00
IUUC-Eca-033743	Equus caballus	97.01	0.00e+00	1206.00
IUUC-Eeu-034505	Erinaceus europaeus	85.46	0.00e+00	698.00
IUUC-Fca-036519	Felis catus	95.92	0.00e+00	1268.00
IUUC-Fal-037295	Ficedula albicollis	89.26	0.00e+00	1098.00
IUUC-Gmo-038650	Gadus morhua	71.96	0.00e+00	924.00
IUUC-Gga-040179	Gallus gallus	88.89	0.00e+00	1178.00
IUUC-Gac-042180	Gasterosteus aculeatus	71.21	0.00e+00	927.00
IUUC-Ggo-044581	Gorilla gorilla	96.87	0.00e+00	1255.00
IUUC-Hsa-046526	Homo sapiens	96.71	0.00e+00	1255.00
IUUC-Itr-048502	Ictidomys tridecemlineatus	95.27	0.00e+00	643.00
IUUC-Lch-049576	Latimeria chalumnae	80.23	0.00e+00	1016.00
IUUC-Loc-051854	Lepisosteus oculatus	78.86	0.00e+00	927.00
IUUC-Laf-054177	Loxodonta africana	95.92	0.00e+00	1261.00
IUUC-Mcc-055185	Macaca mulatta	96.71	0.00e+00	1255.00
IUUC-Meu-056216	Macropus eugenii	90.59	0.00e+00	1058.00
IUUC-Mga-059564	Meleagris gallopavo	89.77	0.00e+00	1102.00
IUUC-Mmr-060934	Microcebus murinus	97.02	0.00e+00	1257.00
IUUC-Mdo-062955	Monodelphis domestica	93.91	0.00e+00	1218.00
IUUC-Mmu-063301	Mus musculus	98.75	0.00e+00	1295.00
IUUC-Mpu-066416	Mustela putorius furo	96.08	0.00e+00	1266.00
IUUC-Mlu-067833	Myotis lucifugus	87.04	0.00e+00	1021.00
IUUC-Nle-069367	Nomascus leucogenys	96.24	0.00e+00	1248.00
IUUC-Opr-070879	Ochotona princeps	84.15	0.00e+00	751.00
IUUC-Ont-072540	Oreochromis niloticus	73.21	0.00e+00	946.00
IUUC-Oan-073124	Ornithorhynchus anatinus	90.17	0.00e+00	889.00
IUUC-Ocu-074796	Oryctolagus cuniculus	96.08	0.00e+00	1245.00
IUUC-Ola-087253	Oryzias latipes	71.56	0.00e+00	941.00
IUUC-Oga-088406	Otolemur garnettii	91.71	0.00e+00	1125.00
IUUC-Oar-090262	Ovis aries	96.39	0.00e+00	1248.00
IUUC-Ptr-091014	Pan troglodytes	96.87	0.00e+00	1255.00
IUUC-Pan-092684	Papio anubis	96.71	0.00e+00	1254.00
IUUC-Psi-093541	Pelodiscus sinensis	90.14	0.00e+00	1179.00
IUUC-Pma-094108	Petromyzon marinus	55.62	3.00e-152	531.00
IUUC-Pfo-097119	Poecilia formosa	71.34	0.00e+00	901.00
IUUC-Pab-097724	Pongo abelii	93.91	0.00e+00	1217.00
IUUC-Pca-100645	Procavia capensis	75.76	0.00e+00	722.00
IUUC-Pva-102322	Pteropus vampyrus	96.81	0.00e+00	1190.00
IUUC-Sha-106673	Sarcophilus harrisii	86.87	0.00e+00	1075.00
IUUC-Ssl-108385	Sclerotinia sclerotiorum	30.95	7.00e-09	54.30
IUUC-Sar-113746	Sorex araneus	76.55	2.00e-98	352.00
IUUC-Ssc-116425	Sus scrofa	97.18	0.00e+00	1208.00
IUUC-Tgu-116520	Taeniopygia guttata	87.95	0.00e+00	1142.00
IUUC-Tru-117750	Takifugu rubripes	67.12	0.00e+00	890.00
IUUC-Tsy-118975	Tarsius syrichta	96.13	0.00e+00	1157.00
IUUC-Tni-119830	Tetraodon nigroviridis	71.16	0.00e+00	902.00
IUUC-Tbe-127895	Tupaia belangeri	95.51	4.00e-132	465.00
IUUC-Ttr-129103	Tursiops truncatus	95.45	0.00e+00	1263.00
IUUC-Vpa-130720	Vicugna pacos	96.94	1.00e-112	400.00
IUUC-Xtr-132314	Xenopus tropicalis	82.03	0.00e+00	1098.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence