iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068894

Ensembl Protein ID

EAA27012

UniProt Accession

Q8WZY7; Q1K4Y7; ATG8_NEUCR

Genbank Protein ID

CAD21230.1; EAA27012.1

Protein Name

Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier atg8

Genbank Nucleotide ID

AL670002; CM002237

Gene Name

atg-8; apg-6; atg8; B24G3.150; NCU01545

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU01545	EAA27012	EAA27012

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	7.50e-48	160.1	13	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgflyvayasee 101
           krk+e+e+ir+k+ d+iPvi+ek +k++i+++dkkkylvP+dltvgq+v++irkr++l +e+a+f++v+++l++++a +++iyee+kdedgfly++y++e+
   Q: 13   KRKAEAERIRQKYSDRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGEN 113
           699************************************************************************************************** PP
   S: 102  tfG 104
           tfG
   Q: 114  TFG 116
           **9 PP

Organism

Neurospora crassa

Functional Description
(View)

Ubiquitin-like modifier involved in autophagosomes formation. With cpr-1/atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The apg-6/atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Protein Sequence
(Fasta)

MRSKFKDEHP FEKRKAEAER IRQKYSDRIP VICEKVEKSD IATIDKKKYL VPADLTVGQF 60
VYVIRKRIKL SPEKAIFIFV DEVLPPTAAL MSSIYEEHKD EDGFLYITYS GENTFGDFET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTACATCGA TGGTCAAAGA GGTACATCAA CCCTTCTTCC CCCTCTTCAT CCTCTTGCCG 60
TTTCTTACCT CTGACATCTC TCCCCAGCTT CCTCATTTCA TCACACGCCA GTCATCAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

ncr:NCU01545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	77.39	7.00e-52	193.00
IUUC-Aml-001323	Ailuropoda melanoleuca	59.48	2.00e-39	151.00
IUUC-Atr-002791	Amborella trichopoda	82.61	8.00e-53	196.00
IUUC-Apl-003994	Anas platyrhynchos	55.17	2.00e-37	145.00
IUUC-Aca-005288	Anolis carolinensis	58.62	5.00e-39	150.00
IUUC-Aly-005987	Arabidopsis lyrata	81.03	3.00e-53	198.00
IUUC-Ath-006958	Arabidopsis thaliana	82.61	4.00e-45	171.00
IUUC-Ago-007898	Ashbya gossypii	71.19	1.00e-48	182.00
IUUC-Acl-008314	Aspergillus clavatus	99.15	8.00e-65	236.00
IUUC-Afl-008708	Aspergillus flavus	98.31	5.00e-65	236.00
IUUC-Afu-009097	Aspergillus fumigatus	99.15	8.00e-65	236.00
IUUC-Ani-009196	Aspergillus nidulans	98.29	4.00e-64	233.00
IUUC-Ang-009530	Aspergillus niger	99.15	8.00e-65	236.00
IUUC-Aor-009909	Aspergillus oryzae	98.31	5.00e-65	236.00
IUUC-Ate-010358	Aspergillus terreus	99.15	8.00e-65	236.00
IUUC-Ame-010914	Astyanax mexicanus	58.97	1.00e-39	152.00
IUUC-Bgr-012248	Blumeria graminis	97.41	4.00e-63	231.00
IUUC-Bta-012805	Bos taurus	59.48	2.00e-39	151.00
IUUC-Bci-013959	Botrytis cinerea	96.58	7.00e-64	233.00
IUUC-Bdi-014390	Brachypodium distachyon	82.61	2.00e-52	195.00
IUUC-Bol-016488	Brassica oleracea	83.48	3.00e-53	197.00
IUUC-Bra-016921	Brassica rapa	81.03	3.00e-53	197.00
IUUC-Cel-018200	Caenorhabditis elegans	56.90	4.00e-37	144.00
IUUC-Cja-019369	Callithrix jacchus	59.48	2.00e-39	151.00
IUUC-Cfa-020603	Canis familiaris	59.48	2.00e-39	151.00
IUUC-Cpo-021831	Cavia porcellus	58.62	6.00e-39	150.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	84.82	7.00e-46	174.00
IUUC-Csa-024117	Chlorocebus sabaeus	59.48	2.00e-39	151.00
IUUC-Cho-025008	Choloepus hoffmanni	51.72	6.00e-35	137.00
IUUC-Cin-025297	Ciona intestinalis	57.76	3.00e-39	151.00
IUUC-Csv-026146	Ciona savignyi	37.61	3.00e-21	91.70
IUUC-Cgl-026691	Colletotrichum gloeosporioides	72.73	4.00e-60	221.00
IUUC-Cne-026889	Cryptococcus neoformans	88.24	5.00e-60	220.00
IUUC-Cme-027158	Cyanidioschyzon merolae	27.50	9.90e-01	25.00
IUUC-Dre-027910	Danio rerio	59.83	7.00e-40	153.00
IUUC-Dno-029331	Dasypus novemcinctus	58.62	5.00e-39	150.00
IUUC-Dor-030245	Dipodomys ordii	59.48	2.00e-39	151.00
IUUC-Dse-031428	Dothistroma septosporum	98.29	1.00e-64	235.00
IUUC-Dme-031813	Drosophila melanogaster	61.21	5.00e-41	157.00
IUUC-Ete-032671	Echinops telfairi	59.48	2.00e-39	152.00
IUUC-Eca-034113	Equus caballus	58.62	8.00e-39	150.00
IUUC-Eeu-035131	Erinaceus europaeus	58.14	1.00e-26	108.00
IUUC-Fca-036493	Felis catus	59.48	3.00e-39	151.00
IUUC-Fal-036896	Ficedula albicollis	58.62	8.00e-39	150.00
IUUC-Fox-037846	Fusarium oxysporum	100.00	3.00e-65	238.00
IUUC-Fso-038134	Fusarium solani	99.15	6.00e-65	236.00
IUUC-Gmo-039671	Gadus morhua	58.97	1.00e-39	153.00
IUUC-Ggr-039770	Gaeumannomyces graminis	94.26	9.00e-63	229.00
IUUC-Gga-040257	Gallus gallus	59.48	1.00e-39	152.00
IUUC-Gac-041604	Gasterosteus aculeatus	59.48	4.00e-40	154.00
IUUC-Gma-044021	Glycine max	80.00	9.00e-53	196.00
IUUC-Ggo-044860	Gorilla gorilla	59.48	3.00e-39	151.00
IUUC-Hsa-045905	Homo sapiens	59.48	2.00e-39	151.00
IUUC-Hvu-047588	Hordeum vulgare	79.83	5.00e-53	197.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	59.48	2.00e-39	151.00
IUUC-Kpa-049124	Komagataella pastoris	82.91	1.00e-55	206.00
IUUC-Lch-049542	Latimeria chalumnae	57.76	5.00e-39	150.00
IUUC-Lpe-051450	Leersia perrieri	82.61	2.00e-53	198.00
IUUC-Loc-052290	Lepisosteus oculatus	59.48	2.00e-39	152.00
IUUC-Laf-054203	Loxodonta africana	59.48	2.00e-39	151.00
IUUC-Mcc-055307	Macaca mulatta	59.48	2.00e-39	151.00
IUUC-Meu-056515	Macropus eugenii	58.62	6.00e-39	150.00
IUUC-Mor-057276	Magnaporthe oryzae	94.92	1.00e-62	229.00
IUUC-Mpo-057469	Magnaporthe poae	94.87	9.00e-62	226.00
IUUC-Mtr-057664	Medicago truncatula	79.13	2.00e-46	175.00
IUUC-Mla-059098	Melampsora laricipopulina	91.38	9.00e-61	223.00
IUUC-Mga-060108	Meleagris gallopavo	54.70	1.00e-37	145.00
IUUC-Mvi-060496	Microbotryum violaceum	91.30	6.00e-59	216.00
IUUC-Mmr-061776	Microcebus murinus	59.48	2.00e-39	151.00
IUUC-Mdo-061915	Monodelphis domestica	58.62	6.00e-39	150.00
IUUC-Mmu-064157	Mus musculus	59.48	2.00e-39	151.00
IUUC-Mac-064739	Musa acuminata	80.00	4.00e-45	171.00
IUUC-Mpu-066028	Mustela putorius furo	59.48	4.00e-39	151.00
IUUC-Mlu-067166	Myotis lucifugus	59.48	2.00e-39	151.00
IUUC-Nfi-068367	Neosartorya fischeri	99.15	8.00e-65	236.00
IUUC-Nle-069220	Nomascus leucogenys	59.48	2.00e-39	151.00
IUUC-Opr-070777	Ochotona princeps	59.48	2.00e-39	151.00
IUUC-Ont-072343	Oreochromis niloticus	58.62	6.00e-39	150.00
IUUC-Oan-073485	Ornithorhynchus anatinus	60.95	7.00e-36	140.00
IUUC-Ocu-074148	Oryctolagus cuniculus	59.48	2.00e-39	151.00
IUUC-Oba-075926	Oryza barthii	81.20	1.00e-52	195.00
IUUC-Obr-076830	Oryza brachyantha	82.61	2.00e-53	198.00
IUUC-Ogl-077457	Oryza glaberrima	81.20	1.00e-52	195.00
IUUC-Ogu-078078	Oryza glumaepatula	81.20	1.00e-52	195.00
IUUC-Oin-079771	Oryza indica	81.20	1.00e-52	195.00
IUUC-Olo-080412	Oryza longistaminata	81.20	1.00e-52	195.00
IUUC-Ome-081791	Oryza meridionalis	81.20	1.00e-52	195.00
IUUC-Oni-082774	Oryza nivara	81.20	1.00e-52	195.00
IUUC-Opu-083501	Oryza punctata	81.74	4.00e-53	197.00
IUUC-Oru-084425	Oryza rufipogon	80.87	4.00e-52	194.00
IUUC-Osa-085439	Oryza sativa	81.20	1.00e-52	195.00
IUUC-Ola-086310	Oryzias latipes	57.76	2.00e-38	148.00
IUUC-Olu-087892	Ostreococcus lucimarinus	81.25	1.00e-52	196.00
IUUC-Oga-088312	Otolemur garnettii	59.48	2.00e-39	151.00
IUUC-Oar-089989	Ovis aries	59.48	2.00e-39	151.00
IUUC-Ptr-091108	Pan troglodytes	59.48	2.00e-39	151.00
IUUC-Pan-092269	Papio anubis	58.62	6.00e-39	150.00
IUUC-Psi-093055	Pelodiscus sinensis	55.17	2.00e-37	145.00
IUUC-Pma-094337	Petromyzon marinus	57.76	2.00e-40	155.00
IUUC-Pno-095035	Phaeosphaeria nodorum	98.29	2.00e-64	235.00
IUUC-Ppa-095701	Physcomitrella patens	83.62	1.00e-47	179.00
IUUC-Pfo-096380	Poecilia formosa	57.76	9.00e-39	149.00
IUUC-Pab-097660	Pongo abelii	59.48	2.00e-39	151.00
IUUC-Pop-100069	Populus trichocarpa	80.51	4.00e-45	171.00
IUUC-Pca-100230	Procavia capensis	59.48	2.00e-39	151.00
IUUC-Ppe-101457	Prunus persica	76.92	6.00e-46	173.00
IUUC-Pva-103103	Pteropus vampyrus	55.17	2.00e-37	145.00
IUUC-Pte-104230	Pyrenophora teres	98.29	2.00e-64	235.00
IUUC-Rno-105497	Rattus norvegicus	59.48	2.00e-39	151.00
IUUC-Sce-106150	Saccharomyces cerevisiae	79.31	1.00e-52	196.00
IUUC-Sha-106656	Sarcophilus harrisii	59.48	2.00e-39	151.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	88.79	4.00e-58	214.00
IUUC-Spo-108156	Schizosaccharomyces pombe	86.21	5.00e-49	184.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	97.44	3.00e-64	234.00
IUUC-Smo-109082	Selaginella moellendorffii	80.87	4.00e-52	194.00
IUUC-Sit-109732	Setaria italica	80.34	5.00e-52	193.00
IUUC-Sly-111488	Solanum lycopersicum	80.34	7.00e-47	176.00
IUUC-Stu-112612	Solanum tuberosum	80.51	3.00e-53	198.00
IUUC-Sar-113670	Sorex araneus	54.31	6.00e-35	137.00
IUUC-Sbi-114346	Sorghum bicolor	81.20	2.00e-52	195.00
IUUC-Sre-114964	Sporisorium reilianum	87.07	1.00e-57	212.00
IUUC-Ssc-116182	Sus scrofa	59.48	2.00e-39	151.00
IUUC-Tgu-117195	Taeniopygia guttata	58.62	6.00e-39	150.00
IUUC-Tru-118632	Takifugu rubripes	59.48	1.00e-39	153.00
IUUC-Tsy-118919	Tarsius syrichta	55.17	2.00e-37	145.00
IUUC-Tni-120706	Tetraodon nigroviridis	57.76	2.00e-38	149.00
IUUC-Tca-121335	Theobroma cacao	79.13	4.00e-46	175.00
IUUC-Tre-122077	Trichoderma reesei	100.00	1.00e-64	236.00
IUUC-Tvi-122400	Trichoderma virens	100.00	1.00e-64	236.00
IUUC-Tae-123593	Triticum aestivum	81.74	4.00e-52	194.00
IUUC-Tur-126158	Triticum urartu	76.52	5.00e-51	190.00
IUUC-Tme-126955	Tuber melanosporum	98.28	5.00e-63	231.00
IUUC-Tbe-127765	Tupaia belangeri	62.79	5.00e-30	119.00
IUUC-Ttr-128205	Tursiops truncatus	58.62	6.00e-39	150.00
IUUC-Uma-129435	Ustilago maydis	85.59	1.00e-57	212.00
IUUC-Vda-129807	Verticillium dahliae	99.17	1.00e-66	242.00
IUUC-Vpa-130804	Vicugna pacos	57.76	1.00e-38	149.00
IUUC-Vvi-130830	Vitis vinifera	82.05	6.00e-47	177.00
IUUC-Xtr-132685	Xenopus tropicalis	58.62	4.00e-39	151.00
IUUC-Xma-133400	Xiphophorus maculatus	59.48	1.00e-39	152.00
IUUC-Yli-134327	Yarrowia lipolytica	90.76	2.00e-53	199.00
IUUC-Zma-135270	Zea mays	82.61	8.00e-53	196.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence