iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bgr-012247

Ensembl Protein ID

CCU81526

UniProt Accession

N1JLT7; N1JLT7_BLUG1

Genbank Protein ID

CCU81526.1

Protein Name

Alanine--tRNA ligase; Alanyl-tRNA synthetase

Genbank Nucleotide ID

CAUH01005147

Gene Name

ALA1; BGHDH14_bgh01997

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
BGHDH14_bgh01997	CCU81526	CCU81526

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	33.33	4.70e-01	28.50	IUUC-Ots-000053

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Blumeria graminis

Functional Description
(View)

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.

Protein Sequence
(Fasta)

MSRNQSHWPA SRVRETFLRY FEGKGHIRVP SSSVVPHNDP TLLFTNAGMN QFKPIFLGTV 60
GNTDNMSRLK RAVDTQKCIR AGGKHNDLDD VGKDTYHHAS NWSFGDYFKP EAVQMSWELL 120

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Nucleotide Sequence
(Fasta)

ATGTCGAGAA ATCAATCGCA TTGGCCTGCT AGCAGAGTGC GTGAGACTTT TCTACGATAC 60
TTCGAAGGGA AGGGACACAT AAGAGGTATG TGTGCAAGAG GGGTAGATAT TTCTAGAAAG 120

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Sequence Source

Ensembl

Keyword

KW-0030--Aminoacyl-tRNA synthetase
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0820--tRNA-binding
KW-0862--Zinc

Interpro

IPR002318--Ala-tRNA-lgiase_IIc
IPR018162--Ala-tRNA-ligase_IIc_anticod-bd
IPR018165--Ala-tRNA-synth_IIc_core
IPR018164--Ala-tRNA-synth_IIc_N
IPR023033--Ala_tRNA_ligase_euk/bac
IPR018163--Thr/Ala-tRNA-synth_IIc_edit
IPR009000--Transl_B-barrel
IPR012947--tRNA_SAD

PROSITE

PS50860--AA_TRNA_LIGASE_II_ALA

Pfam

PF01411--tRNA-synt_2c
PF07973--tRNA_SAD

PRINTS

PR00980--TRNASYNTHALA

SMART

SM00863--tRNA_SAD

Gene Ontology

GO:0005739--C:mitochondrion
GO:0004813--F:alanine-tRNA ligase activity
GO:0005524--F:ATP binding
GO:0000049--F:tRNA binding
GO:0008270--F:zinc ion binding
GO:0070143--P:mitochondrial alanyl-tRNA aminoacylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000807	Aegilops tauschii	31.58	1.30e-01	28.10
IUUC-Apl-003605	Anas platyrhynchos	34.62	5.00e-01	28.10
IUUC-Ago-007739	Ashbya gossypii	26.98	1.30e-01	30.00
IUUC-Bci-013976	Botrytis cinerea	25.00	4.50e-02	31.20
IUUC-Cfa-020129	Canis familiaris	35.42	3.10e-01	30.00
IUUC-Csa-023238	Chlorocebus sabaeus	29.41	1.20e-01	28.90
IUUC-Cho-024962	Choloepus hoffmanni	19.82	3.70e-01	27.70
IUUC-Dno-028891	Dasypus novemcinctus	31.37	8.70e-02	29.60
IUUC-Eeu-034997	Erinaceus europaeus	29.41	4.00e-01	27.70
IUUC-Fca-035730	Felis catus	39.58	5.20e-02	32.30
IUUC-Gga-041088	Gallus gallus	41.46	8.30e-01	28.50
IUUC-Hsa-046932	Homo sapiens	20.34	1.00e-02	33.10
IUUC-Itr-048776	Ictidomys tridecemlineatus	28.00	2.80e-01	28.10
IUUC-Loc-052168	Lepisosteus oculatus	41.38	9.90e-02	29.30
IUUC-Laf-053461	Loxodonta africana	29.41	1.50e-01	28.90
IUUC-Mcc-055411	Macaca mulatta	21.91	9.10e-02	29.60
IUUC-Mga-059880	Meleagris gallopavo	41.46	8.00e-01	28.50
IUUC-Mdo-062514	Monodelphis domestica	32.50	1.30e-01	29.30
IUUC-Mmu-063183	Mus musculus	19.77	1.00e-01	29.60
IUUC-Mpu-066430	Mustela putorius furo	20.72	1.50e-01	29.30
IUUC-Mlu-067318	Myotis lucifugus	29.41	1.80e-01	28.90
IUUC-Nle-069871	Nomascus leucogenys	20.96	2.00e-03	35.00
IUUC-Ptr-091222	Pan troglodytes	20.90	1.00e-03	35.80
IUUC-Pan-092930	Papio anubis	20.00	1.50e-01	29.30
IUUC-Pca-101038	Procavia capensis	22.52	9.00e-03	33.10
IUUC-Ppe-101401	Prunus persica	34.78	1.90e+00	25.80
IUUC-Pva-102707	Pteropus vampyrus	31.37	1.50e-01	28.90
IUUC-Tsy-119162	Tarsius syrichta	29.41	2.70e-01	27.70
IUUC-Tbe-127998	Tupaia belangeri	29.41	2.50e-01	28.50
IUUC-Vpa-130281	Vicugna pacos	23.72	6.00e-03	34.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence