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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105620
UUCD1 version UUC-RaN-00884
Ensembl Protein ID ENSRNOP00000072362.1
UniProt Accession Q63364; PJA2_RAT
Genbank Protein ID BAA06979.1; AAH74015.1
Protein Name E3 ubiquitin-protein ligase Praja-2; RING-type E3 ubiquitin transferase Praja-2
Genbank Nucleotide ID D32249; BC074015
Gene Name Pja2; Neurodap1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000015528.7 ENSRNOT00000080962.1 ENSRNOP00000072362.1
ENSRNOG00000015528.7 ENSRNOT00000021258.7 ENSRNOP00000021258.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.50e-06 28.3 633 674
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++  +d    lpC H+fh+ C+  w       +k+ +CP+Cr
   Q: 633  CPICCSEYikDDIATELPCHHFFHKPCVSIW------LQKSGTCPVCR 674
           ******99753324449**************......**********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
 Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
Protein Sequence
(Fasta)
MSQYTEKEPS VMDQDSSKAA WPRAAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG 60
DDYEVLELDD VAKENTAGSS SLDQVHPSLP SETTVEKSET EIPTCGPALN QSTESNPSVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105620|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCATTTGCA GCTTATTCAC TGTGTAAGGA AAAACCAAAT TACATCCATA ATTCTATTGA 60
ACTGGAAGCA TAGACGCTGC CATATATGTC ACAGTATACA GAAAAAGAAC CATCAGGTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105620|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR030639--Praja-2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0045111--C:intermediate filament cytoskeleton
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035329--P:hippo signaling
GO:0007616--P:long-term memory
GO:0010738--P:regulation of protein kinase A signaling
KEGG rno:192256
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001388 Ailuropoda melanoleuca 78.93 0.00e+00 1086.00
IUUC-Apl-003808 Anas platyrhynchos 67.57 4.00e-59 220.00
IUUC-Aca-004858 Anolis carolinensis 45.51 1.00e-141 497.00
IUUC-Ago-007872 Ashbya gossypii 35.56 3.00e-09 54.30
IUUC-Ame-010842 Astyanax mexicanus 60.39 5.00e-63 235.00
IUUC-Bta-013122 Bos taurus 78.48 0.00e+00 1085.00
IUUC-Cja-019345 Callithrix jacchus 76.12 0.00e+00 795.00
IUUC-Cfa-021193 Canis familiaris 81.50 0.00e+00 1076.00
IUUC-Cpo-021991 Cavia porcellus 77.95 0.00e+00 1061.00
IUUC-Csa-024052 Chlorocebus sabaeus 82.09 0.00e+00 1065.00
IUUC-Cho-024680 Choloepus hoffmanni 79.32 0.00e+00 1084.00
IUUC-Cme-027116 Cyanidioschyzon merolae 43.18 2.00e-09 56.20
IUUC-Dre-027662 Danio rerio 46.39 4.00e-64 239.00
IUUC-Dno-028851 Dasypus novemcinctus 80.43 0.00e+00 1096.00
IUUC-Dor-031005 Dipodomys ordii 75.81 0.00e+00 843.00
IUUC-Ete-032637 Echinops telfairi 63.66 2.00e-114 406.00
IUUC-Eca-034011 Equus caballus 79.36 0.00e+00 896.00
IUUC-Eeu-034596 Erinaceus europaeus 75.00 0.00e+00 966.00
IUUC-Fca-036523 Felis catus 80.93 0.00e+00 1056.00
IUUC-Fal-037255 Ficedula albicollis 41.07 1.00e-108 387.00
IUUC-Gga-040434 Gallus gallus 45.58 8.00e-128 451.00
IUUC-Hsa-046514 Homo sapiens 81.94 0.00e+00 1083.00
IUUC-Itr-047883 Ictidomys tridecemlineatus 81.82 0.00e+00 1071.00
IUUC-Lch-050133 Latimeria chalumnae 33.52 1.00e-47 184.00
IUUC-Loc-051901 Lepisosteus oculatus 39.19 1.00e-105 377.00
IUUC-Laf-054289 Loxodonta africana 78.75 0.00e+00 1049.00
IUUC-Mcc-055552 Macaca mulatta 82.53 0.00e+00 1092.00
IUUC-Meu-056394 Macropus eugenii 75.45 8.00e-109 387.00
IUUC-Mga-059909 Meleagris gallopavo 75.51 2.00e-23 100.00
IUUC-Mmr-060712 Microcebus murinus 79.55 0.00e+00 1031.00
IUUC-Mdo-062457 Monodelphis domestica 52.57 0.00e+00 649.00
IUUC-Mmu-063933 Mus musculus 92.02 0.00e+00 1249.00
IUUC-Mpu-065994 Mustela putorius furo 81.73 0.00e+00 1105.00
IUUC-Mlu-067843 Myotis lucifugus 77.23 0.00e+00 1028.00
IUUC-Nle-069787 Nomascus leucogenys 81.94 0.00e+00 1079.00
IUUC-Opr-071190 Ochotona princeps 65.59 2.00e-116 412.00
IUUC-Oan-072728 Ornithorhynchus anatinus 30.84 9.00e-59 221.00
IUUC-Ocu-074152 Oryctolagus cuniculus 81.19 0.00e+00 1054.00
IUUC-Oga-088608 Otolemur garnettii 80.32 0.00e+00 1058.00
IUUC-Oar-090415 Ovis aries 76.88 0.00e+00 1028.00
IUUC-Ptr-091211 Pan troglodytes 82.09 0.00e+00 1083.00
IUUC-Pan-091698 Papio anubis 77.97 0.00e+00 1008.00
IUUC-Psi-093139 Pelodiscus sinensis 48.91 8.00e-133 467.00
IUUC-Pab-097745 Pongo abelii 81.20 0.00e+00 1071.00
IUUC-Pca-100681 Procavia capensis 73.87 0.00e+00 946.00
IUUC-Pva-102525 Pteropus vampyrus 79.44 0.00e+00 1075.00
IUUC-Sce-106223 Saccharomyces cerevisiae 48.89 9.00e-09 53.10
IUUC-Sha-106812 Sarcophilus harrisii 48.34 7.00e-114 404.00
IUUC-Sar-113270 Sorex araneus 85.59 4.00e-164 571.00
IUUC-Ssc-115913 Sus scrofa 69.70 2.00e-170 592.00
IUUC-Tgu-117101 Taeniopygia guttata 58.63 4.00e-68 251.00
IUUC-Tsy-119078 Tarsius syrichta 77.12 0.00e+00 871.00
IUUC-Tca-121240 Theobroma cacao 35.14 3.00e-13 68.20
IUUC-Tbe-127715 Tupaia belangeri 77.21 0.00e+00 1011.00
IUUC-Ttr-129003 Tursiops truncatus 81.72 0.00e+00 1134.00
IUUC-Vpa-130373 Vicugna pacos 81.54 0.00e+00 1092.00
Created Date 25-Jun-2017

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