iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.00e-17	62.9	83	152

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           aDv +vvg     + ++ahk+vLa  SsvFya+f+++l e   k++++i dv+p +f  llk++Y++++d++
   Q: 83   ADVHFVVGppgaTRTVPAHKYVLAVGSSVFYAMFYGDLAEV--KSEIHIPDVEPAAFLILLKYMYSDEIDLE 152
           69*****666689***************************9..5*************************985 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development and muscle formation (By similarity).

Protein Sequence
(Fasta)

MAAELYAPAS AAAADLANSN AGAAVGRKAG PRSPPSAPAP APPPPAPAPP TLGNNHQESP 60
GWRCCRPTLR ERNALMFNNE LMADVHFVVG PPGATRTVPA HKYVLAVGSS VFYAMFYGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGCCGCG AGGCAGCGAC GTCGCGCGGG GCGCGGCCCT GACGCAGCGT GACGCACCGG 60
CGCCGCGGCG GGTACGGGCT CGGGCGGGCG GGCGGGCGGG ACGGCGCCCC CCGCGGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0000932--C:P-body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

hsa:90135

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001698	Ailuropoda melanoleuca	95.94	0.00e+00	835.00
IUUC-Apl-003687	Anas platyrhynchos	92.76	0.00e+00	839.00
IUUC-Aca-004837	Anolis carolinensis	92.06	0.00e+00	830.00
IUUC-Ame-010962	Astyanax mexicanus	87.97	0.00e+00	788.00
IUUC-Bta-013321	Bos taurus	96.59	0.00e+00	821.00
IUUC-Bci-013714	Botrytis cinerea	31.68	3.00e-05	42.70
IUUC-Cja-018819	Callithrix jacchus	98.62	0.00e+00	890.00
IUUC-Cfa-020312	Canis familiaris	94.88	0.00e+00	809.00
IUUC-Cpo-021713	Cavia porcellus	93.06	0.00e+00	867.00
IUUC-Csa-023707	Chlorocebus sabaeus	99.51	0.00e+00	851.00
IUUC-Dre-028757	Danio rerio	88.68	0.00e+00	793.00
IUUC-Dno-029600	Dasypus novemcinctus	96.23	0.00e+00	744.00
IUUC-Eca-033474	Equus caballus	95.37	0.00e+00	857.00
IUUC-Fca-036108	Felis catus	96.10	0.00e+00	819.00
IUUC-Fal-037012	Ficedula albicollis	93.81	0.00e+00	833.00
IUUC-Gmo-038628	Gadus morhua	83.25	0.00e+00	746.00
IUUC-Gga-040672	Gallus gallus	92.99	0.00e+00	842.00
IUUC-Gac-041592	Gasterosteus aculeatus	86.45	0.00e+00	776.00
IUUC-Ggo-044914	Gorilla gorilla	99.78	0.00e+00	921.00
IUUC-Itr-048159	Ictidomys tridecemlineatus	94.86	0.00e+00	849.00
IUUC-Lch-049492	Latimeria chalumnae	89.98	0.00e+00	797.00
IUUC-Loc-052121	Lepisosteus oculatus	89.40	0.00e+00	823.00
IUUC-Laf-054023	Loxodonta africana	96.86	0.00e+00	835.00
IUUC-Mcc-055221	Macaca mulatta	99.76	0.00e+00	853.00
IUUC-Meu-056880	Macropus eugenii	90.98	0.00e+00	791.00
IUUC-Mga-059788	Meleagris gallopavo	92.76	0.00e+00	837.00
IUUC-Mmr-061333	Microcebus murinus	97.07	0.00e+00	830.00
IUUC-Mdo-062071	Monodelphis domestica	89.58	0.00e+00	822.00
IUUC-Mmu-064273	Mus musculus	95.14	0.00e+00	859.00
IUUC-Mpu-065966	Mustela putorius furo	94.88	0.00e+00	811.00
IUUC-Mlu-066940	Myotis lucifugus	93.75	0.00e+00	816.00
IUUC-Nle-070099	Nomascus leucogenys	99.51	0.00e+00	850.00
IUUC-Opr-070931	Ochotona princeps	94.39	0.00e+00	810.00
IUUC-Ont-071493	Oreochromis niloticus	87.62	0.00e+00	793.00
IUUC-Ocu-074781	Oryctolagus cuniculus	94.15	0.00e+00	808.00
IUUC-Ola-086691	Oryzias latipes	86.90	0.00e+00	790.00
IUUC-Oga-088166	Otolemur garnettii	95.56	0.00e+00	853.00
IUUC-Oar-090170	Ovis aries	93.76	0.00e+00	810.00
IUUC-Pan-092894	Papio anubis	95.43	0.00e+00	901.00
IUUC-Psi-093858	Pelodiscus sinensis	93.57	0.00e+00	830.00
IUUC-Pfo-096949	Poecilia formosa	85.06	0.00e+00	786.00
IUUC-Pca-100556	Procavia capensis	96.08	0.00e+00	767.00
IUUC-Rno-105298	Rattus norvegicus	94.68	0.00e+00	852.00
IUUC-Sha-107182	Sarcophilus harrisii	88.89	0.00e+00	815.00
IUUC-Tgu-117158	Taeniopygia guttata	93.81	0.00e+00	834.00
IUUC-Tru-118020	Takifugu rubripes	85.75	0.00e+00	768.00
IUUC-Tni-120203	Tetraodon nigroviridis	83.41	0.00e+00	760.00
IUUC-Tbe-127750	Tupaia belangeri	92.14	0.00e+00	773.00
IUUC-Ttr-128417	Tursiops truncatus	95.30	0.00e+00	750.00
IUUC-Xtr-132362	Xenopus tropicalis	90.65	0.00e+00	814.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence