iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198625.12	ENST00000391947.6	ENSP00000375811.2
ENSG00000198625.12	ENST00000367182.7	ENSP00000356150.3
ENSG00000198625.12	ENST00000367180.5	ENSP00000356148.1
ENSG00000198625.12	ENST00000367179.7	ENSP00000356147.3
ENSG00000198625.12	ENST00000614459.4	ENSP00000482388.1
ENSG00000198625.12	ENST00000616250.4	ENSP00000478581.1
ENSG00000198625.12	ENST00000612738.4	ENSP00000478080.1
ENSG00000198625.12	ENST00000367183.7	ENSP00000356151.3
ENSG00000198625.12	ENST00000454264.6	ENSP00000396840.2
ENSG00000198625.12	ENST00000621032.4	ENSP00000482479.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18567799; 12393902

Organism

Homo sapiens

Functional Description
(View)

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Protein Sequence
(Fasta)

MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGGAGG CCGGAAGTTG CGGCTTCATT ACTCGCCATT TCAAAATGCT GCCGAGGCCC 60
TAGGATCTGT GACTGCCACC CCTCCCCCCA CCCGGGCTCG GCGGGGGAGC GACTCATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019899--F:enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0008285--P:negative regulation of cell proliferation
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:1901796--P:regulation of signal transduction by p53 class mediator

KEGG

hsa:4194

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001467	Ailuropoda melanoleuca	92.89	0.00e+00	806.00
IUUC-Apl-003800	Anas platyrhynchos	60.32	4.00e-154	537.00
IUUC-Aca-004608	Anolis carolinensis	57.43	1.00e-136	479.00
IUUC-Ame-010869	Astyanax mexicanus	46.45	2.00e-105	376.00
IUUC-Bta-013287	Bos taurus	90.02	0.00e+00	857.00
IUUC-Cja-019305	Callithrix jacchus	94.90	0.00e+00	855.00
IUUC-Cfa-020393	Canis familiaris	93.50	0.00e+00	827.00
IUUC-Cpo-022166	Cavia porcellus	89.27	0.00e+00	751.00
IUUC-Csa-023654	Chlorocebus sabaeus	97.96	0.00e+00	853.00
IUUC-Cho-024403	Choloepus hoffmanni	90.64	4.00e-129	454.00
IUUC-Cin-025448	Ciona intestinalis	27.60	3.00e-21	95.10
IUUC-Cgl-026403	Colletotrichum gloeosporioides	34.88	4.20e-01	31.20
IUUC-Dre-027754	Danio rerio	49.01	2.00e-115	409.00
IUUC-Dno-029630	Dasypus novemcinctus	89.43	0.00e+00	822.00
IUUC-Dor-031064	Dipodomys ordii	69.45	0.00e+00	650.00
IUUC-Ete-032901	Echinops telfairi	79.27	0.00e+00	756.00
IUUC-Eca-034234	Equus caballus	94.50	0.00e+00	903.00
IUUC-Eeu-035015	Erinaceus europaeus	65.04	7.00e-158	550.00
IUUC-Fca-036587	Felis catus	93.08	0.00e+00	838.00
IUUC-Fal-036906	Ficedula albicollis	53.97	3.00e-137	482.00
IUUC-Gmo-038646	Gadus morhua	43.70	4.00e-95	342.00
IUUC-Gga-040124	Gallus gallus	59.41	5.00e-114	404.00
IUUC-Gac-042397	Gasterosteus aculeatus	45.82	6.00e-106	377.00
IUUC-Ggo-045505	Gorilla gorilla	99.59	0.00e+00	897.00
IUUC-Itr-048886	Ictidomys tridecemlineatus	91.04	0.00e+00	830.00
IUUC-Lch-050141	Latimeria chalumnae	54.29	1.00e-120	426.00
IUUC-Loc-051921	Lepisosteus oculatus	50.10	5.00e-115	407.00
IUUC-Laf-054281	Loxodonta africana	87.17	0.00e+00	783.00
IUUC-Mcc-055462	Macaca mulatta	94.50	0.00e+00	803.00
IUUC-Meu-056294	Macropus eugenii	70.86	1.00e-144	506.00
IUUC-Mga-059924	Meleagris gallopavo	60.45	3.00e-165	574.00
IUUC-Mmr-061428	Microcebus murinus	92.46	0.00e+00	868.00
IUUC-Mdo-062643	Monodelphis domestica	76.06	0.00e+00	720.00
IUUC-Mmu-063229	Mus musculus	83.91	0.00e+00	770.00
IUUC-Mpu-065782	Mustela putorius furo	91.08	0.00e+00	813.00
IUUC-Mlu-068105	Myotis lucifugus	81.30	0.00e+00	769.00
IUUC-Nle-069549	Nomascus leucogenys	99.59	0.00e+00	897.00
IUUC-Opr-070568	Ochotona princeps	90.11	0.00e+00	772.00
IUUC-Ont-072276	Oreochromis niloticus	47.00	6.00e-116	410.00
IUUC-Oan-072787	Ornithorhynchus anatinus	73.29	0.00e+00	649.00
IUUC-Ocu-074912	Oryctolagus cuniculus	89.82	0.00e+00	816.00
IUUC-Ola-087037	Oryzias latipes	44.71	7.00e-97	347.00
IUUC-Oga-088953	Otolemur garnettii	89.09	0.00e+00	814.00
IUUC-Oar-089202	Ovis aries	90.02	0.00e+00	860.00
IUUC-Ptr-090964	Pan troglodytes	99.59	0.00e+00	898.00
IUUC-Pan-091975	Papio anubis	98.16	0.00e+00	873.00
IUUC-Psi-093558	Pelodiscus sinensis	60.49	7.00e-157	546.00
IUUC-Pfo-096454	Poecilia formosa	47.05	1.00e-108	387.00
IUUC-Pab-098123	Pongo abelii	98.98	0.00e+00	894.00
IUUC-Pca-101112	Procavia capensis	78.46	0.00e+00	721.00
IUUC-Pva-103098	Pteropus vampyrus	82.28	0.00e+00	767.00
IUUC-Rno-105930	Rattus norvegicus	83.94	0.00e+00	741.00
IUUC-Sha-107512	Sarcophilus harrisii	73.98	0.00e+00	640.00
IUUC-Sar-113584	Sorex araneus	82.69	0.00e+00	717.00
IUUC-Tgu-116766	Taeniopygia guttata	57.01	7.00e-101	360.00
IUUC-Tru-117829	Takifugu rubripes	47.33	9.00e-112	397.00
IUUC-Tsy-119268	Tarsius syrichta	78.21	0.00e+00	678.00
IUUC-Tni-120204	Tetraodon nigroviridis	46.56	1.00e-108	387.00
IUUC-Tbe-127840	Tupaia belangeri	86.04	4.00e-128	451.00
IUUC-Ttr-128863	Tursiops truncatus	89.82	0.00e+00	827.00
IUUC-Vpa-130718	Vicugna pacos	92.69	0.00e+00	804.00
IUUC-Xtr-132320	Xenopus tropicalis	47.39	3.00e-89	322.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence