iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096330

Ensembl Protein ID

ENSPFOP00000005599.2

UniProt Accession

A0A087XIJ6; A0A087XIJ6_POEFO

Genbank Protein ID

ENSPFOP00000005599

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AYCK01006706

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000005634.1	ENSPFOT00000005608.1	ENSPFOP00000005599.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-100	337.6	160	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             ++  + +++ +++ +l+++++k + +lw+++++a+sp +l+ a++
   Q: 160  TGLRNLGNTCFMNAILQSLSNIEQFSCYFKElpavalrsgktAGRRMYHTRSQGNNSVSLVEEFRKTLCSLWQGSQTAFSPDSLFYAIW 248
           7******************************888888777663444444444577888******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l++el+ ++n      + +d  +ls   ++   + ++s+++ +F+g l++++ cl c+++s +++
   Q: 249  KIMPSFRGYQQQDAHEFMRYLLDHLHRELQYSRNGASYPVSPQDGVRLSTTDSKCCINGTSSVVTSVFGGILQNEVNCLICGTESRKFD 337
           *****************************9999999999999999999999************************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + yyc kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 338  PFLDLSLDIPSQFRQKRSkdqepgpicTLRDCLRSFTDLEELDETELYYCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHW--TAFLRN 424
           **********7776655577899********************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ f+ +pe++   ++ Y+L avvvH+G +++sGHY+ay  + +g+W++f+Ds+Vt ++e++v++   ++aY+lf
   Q: 425  KVDTYVEFPLKgLDMRGFLLEPENTLPGSCLYDLAAVVVHHGsGVGSGHYTAYGSH-EGHWYHFNDSTVTLTNEDTVKK---AKAYILF 509
           ********************************************************.999*******************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 510  YVE 512
           *76 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MECPHLSSNV SCTTDSPRFP NGTPSSWCCN VCRSNKSPWI CLTCLMVHCG RYVNGHAKKH 60
FEENQGPSIC QRKGEKQEKD KTYHSVCMDC SNFSVFCYRC DDFVVNDTKL GHTQKVREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGATGAGACT GCCTACACAC CCATTTCTAT CTTTTATGCA CAAGGACGGA AGCGCTAAAG 60
CGCTTTTCTC TGAGGCTTTT CATCTTTGTG ACGAAAACCA GCGAGAGCCG GTGGAATGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	78.31	0.00e+00	781.00
IUUC-Apl-003358	Anas platyrhynchos	79.23	0.00e+00	722.00
IUUC-Aca-004454	Anolis carolinensis	77.09	0.00e+00	692.00
IUUC-Ame-011544	Astyanax mexicanus	77.48	0.00e+00	769.00
IUUC-Bta-012738	Bos taurus	78.35	0.00e+00	738.00
IUUC-Cel-018186	Caenorhabditis elegans	36.74	2.00e-61	229.00
IUUC-Cja-018893	Callithrix jacchus	77.93	0.00e+00	746.00
IUUC-Cfa-020607	Canis familiaris	78.50	0.00e+00	744.00
IUUC-Cpo-021828	Cavia porcellus	78.14	0.00e+00	736.00
IUUC-Csa-023884	Chlorocebus sabaeus	80.90	4.00e-180	624.00
IUUC-Cho-024863	Choloepus hoffmanni	70.83	0.00e+00	647.00
IUUC-Dre-028452	Danio rerio	77.74	0.00e+00	800.00
IUUC-Dno-029531	Dasypus novemcinctus	78.41	0.00e+00	692.00
IUUC-Dor-030913	Dipodomys ordii	70.33	4.00e-138	484.00
IUUC-Ete-032611	Echinops telfairi	73.32	0.00e+00	697.00
IUUC-Eca-033622	Equus caballus	79.02	0.00e+00	696.00
IUUC-Eeu-035268	Erinaceus europaeus	76.19	0.00e+00	634.00
IUUC-Fca-035801	Felis catus	79.02	0.00e+00	717.00
IUUC-Fal-036749	Ficedula albicollis	78.46	0.00e+00	694.00
IUUC-Gmo-039598	Gadus morhua	83.01	0.00e+00	854.00
IUUC-Gga-040883	Gallus gallus	79.23	0.00e+00	697.00
IUUC-Gac-042235	Gasterosteus aculeatus	87.69	0.00e+00	886.00
IUUC-Ggo-044767	Gorilla gorilla	73.98	0.00e+00	653.00
IUUC-Hsa-046581	Homo sapiens	78.12	0.00e+00	765.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	77.93	0.00e+00	739.00
IUUC-Lch-049732	Latimeria chalumnae	77.69	0.00e+00	805.00
IUUC-Loc-052371	Lepisosteus oculatus	80.08	0.00e+00	826.00
IUUC-Laf-054565	Loxodonta africana	77.54	0.00e+00	737.00
IUUC-Mcc-055522	Macaca mulatta	78.31	0.00e+00	768.00
IUUC-Meu-056754	Macropus eugenii	68.66	1.00e-138	486.00
IUUC-Mga-060095	Meleagris gallopavo	76.18	8.00e-146	509.00
IUUC-Mmr-060839	Microcebus murinus	78.31	0.00e+00	745.00
IUUC-Mdo-062339	Monodelphis domestica	81.50	3.00e-177	614.00
IUUC-Mmu-063638	Mus musculus	77.95	0.00e+00	720.00
IUUC-Mpu-066647	Mustela putorius furo	80.41	9.00e-178	616.00
IUUC-Mlu-067921	Myotis lucifugus	77.80	0.00e+00	713.00
IUUC-Nle-069752	Nomascus leucogenys	78.50	0.00e+00	769.00
IUUC-Opr-070636	Ochotona princeps	67.56	1.00e-170	593.00
IUUC-Ont-071638	Oreochromis niloticus	81.80	0.00e+00	875.00
IUUC-Oan-073417	Ornithorhynchus anatinus	73.13	0.00e+00	703.00
IUUC-Ocu-074620	Oryctolagus cuniculus	79.34	0.00e+00	740.00
IUUC-Ola-087281	Oryzias latipes	89.10	0.00e+00	758.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.02	5.00e-54	204.00
IUUC-Oga-088448	Otolemur garnettii	78.31	0.00e+00	771.00
IUUC-Oar-090132	Ovis aries	78.12	0.00e+00	738.00
IUUC-Ptr-090696	Pan troglodytes	78.82	0.00e+00	718.00
IUUC-Pan-092124	Papio anubis	78.12	0.00e+00	764.00
IUUC-Psi-093801	Pelodiscus sinensis	80.41	9.00e-177	613.00
IUUC-Pma-094472	Petromyzon marinus	70.87	3.00e-91	327.00
IUUC-Pab-098191	Pongo abelii	78.50	0.00e+00	768.00
IUUC-Pca-100341	Procavia capensis	76.96	1.00e-165	576.00
IUUC-Pva-103177	Pteropus vampyrus	78.08	0.00e+00	739.00
IUUC-Rno-105048	Rattus norvegicus	76.58	0.00e+00	714.00
IUUC-Sha-107429	Sarcophilus harrisii	79.23	0.00e+00	694.00
IUUC-Sar-113024	Sorex araneus	78.72	0.00e+00	650.00
IUUC-Ssc-115749	Sus scrofa	77.50	2.00e-120	425.00
IUUC-Tgu-117277	Taeniopygia guttata	79.06	0.00e+00	716.00
IUUC-Tru-117844	Takifugu rubripes	87.88	0.00e+00	924.00
IUUC-Tsy-119456	Tarsius syrichta	75.92	0.00e+00	684.00
IUUC-Tni-120251	Tetraodon nigroviridis	83.30	0.00e+00	916.00
IUUC-Tbe-127423	Tupaia belangeri	73.51	0.00e+00	681.00
IUUC-Ttr-128401	Tursiops truncatus	72.65	1.00e-178	619.00
IUUC-Vpa-130549	Vicugna pacos	68.55	1.00e-127	449.00
IUUC-Xtr-131892	Xenopus tropicalis	72.66	0.00e+00	691.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence