iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010363.5	ENSGALT00000016877.4	ENSGALP00000016858.4
ENSGALG00000010363.5	ENSGALT00000016878.5	ENSGALP00000016859.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-94	317.4	727	1050

Active Site

Position(s)	Description	Evidence
1019	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 727  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYPESNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 808
           899**********************************************999777554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl++++++  +diee+ ++l+f++  e++g t++++L+++G++i+V ++N+e++v+++
   Q: 809  HFPLALYKKLLNVKPCLEDLKELSPTEGRSLQQLLDYPGEDIEET-FCLNFTICRESYGVTEHKNLIEDGDKIQVQKDNREKFVEAY 894
           *******************************************98.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +i+e ++af+ Gf +v+  ++l+lF++ el+ +i G++++++e+l++ + ykg+yt+++p++++Fwe++++f  e++k+f
   Q: 895  VNYIFNCSIHEWYTAFSTGFLKVCGGKVLELFQPTELRAMIVGNSNYNWEELEESAVYKGDYTATHPTVRMFWETFHAFPLEKKKKF 981
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L+ Ai++ +gF+l
   Q: 982  LLFLTGSDRIPIYGMSSLR---IVIQStANGEQYLPVAHTCYNLLDLPKYSSKEILSARLMQAIDHYEGFSL 1050
           *******************...8888868888**************************************97 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MLCWGYSSFG QPGIGSNLQV IIPEPQVYGF IHDRNVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHES EGSKPEPIGA LAGQHIVHVA CGESHSVALS DQGQVFSWGA GSDGQLGLTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCAGCG GCGGGGCCGG TGGCAGGTGG GTTGGGAGGT GATCGGGTGG CCGTGGTGTT 60
GCGGAGGAGC CCCTTGCGGA GGGCGCGAGC GTGGAGCGCC CCAGCAGGCG CCGTGTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	87.54	0.00e+00	1853.00
IUUC-Apl-003535	Anas platyrhynchos	98.10	0.00e+00	2062.00
IUUC-Aca-005223	Anolis carolinensis	88.20	0.00e+00	1867.00
IUUC-Ame-010816	Astyanax mexicanus	65.60	0.00e+00	1158.00
IUUC-Bta-013373	Bos taurus	87.44	0.00e+00	1857.00
IUUC-Cel-018150	Caenorhabditis elegans	34.23	2.00e-155	543.00
IUUC-Cja-019609	Callithrix jacchus	87.06	0.00e+00	1846.00
IUUC-Cfa-021071	Canis familiaris	87.35	0.00e+00	1848.00
IUUC-Cpo-021548	Cavia porcellus	86.39	0.00e+00	1837.00
IUUC-Csa-023987	Chlorocebus sabaeus	87.44	0.00e+00	1852.00
IUUC-Cho-024325	Choloepus hoffmanni	88.94	0.00e+00	1089.00
IUUC-Dre-027472	Danio rerio	66.86	0.00e+00	1399.00
IUUC-Dno-029241	Dasypus novemcinctus	86.70	0.00e+00	1836.00
IUUC-Dor-030672	Dipodomys ordii	80.85	0.00e+00	986.00
IUUC-Ete-032642	Echinops telfairi	82.87	0.00e+00	1694.00
IUUC-Eca-033646	Equus caballus	87.63	0.00e+00	1853.00
IUUC-Eeu-035098	Erinaceus europaeus	76.40	0.00e+00	1223.00
IUUC-Fal-036952	Ficedula albicollis	97.43	0.00e+00	2052.00
IUUC-Gmo-039297	Gadus morhua	65.65	0.00e+00	1334.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.65	0.00e+00	1380.00
IUUC-Ggo-044769	Gorilla gorilla	86.98	0.00e+00	1844.00
IUUC-Hsa-046066	Homo sapiens	87.25	0.00e+00	1848.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	87.07	0.00e+00	1847.00
IUUC-Lch-050301	Latimeria chalumnae	73.55	0.00e+00	1600.00
IUUC-Loc-052803	Lepisosteus oculatus	67.47	0.00e+00	1439.00
IUUC-Laf-053364	Loxodonta africana	87.25	0.00e+00	1846.00
IUUC-Mcc-054930	Macaca mulatta	87.35	0.00e+00	1851.00
IUUC-Meu-056274	Macropus eugenii	75.23	0.00e+00	820.00
IUUC-Mtr-058277	Medicago truncatula	38.89	6.00e-53	201.00
IUUC-Mga-059563	Meleagris gallopavo	99.24	0.00e+00	2083.00
IUUC-Mmr-060792	Microcebus murinus	86.77	0.00e+00	1828.00
IUUC-Mdo-062195	Monodelphis domestica	88.59	0.00e+00	1878.00
IUUC-Mmu-063855	Mus musculus	85.63	0.00e+00	1824.00
IUUC-Mpu-066308	Mustela putorius furo	87.63	0.00e+00	1853.00
IUUC-Mlu-066927	Myotis lucifugus	87.35	0.00e+00	1847.00
IUUC-Nle-070090	Nomascus leucogenys	87.25	0.00e+00	1851.00
IUUC-Opr-070891	Ochotona princeps	76.59	0.00e+00	1571.00
IUUC-Ont-072201	Oreochromis niloticus	64.09	0.00e+00	1330.00
IUUC-Ocu-074770	Oryctolagus cuniculus	87.35	0.00e+00	1853.00
IUUC-Ola-086550	Oryzias latipes	65.09	0.00e+00	1382.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.13	2.00e-42	166.00
IUUC-Oga-088831	Otolemur garnettii	87.06	0.00e+00	1847.00
IUUC-Oar-090449	Ovis aries	87.54	0.00e+00	1849.00
IUUC-Pan-092135	Papio anubis	87.36	0.00e+00	1847.00
IUUC-Psi-093832	Pelodiscus sinensis	89.15	0.00e+00	1921.00
IUUC-Pfo-097268	Poecilia formosa	65.56	0.00e+00	1373.00
IUUC-Pab-098249	Pongo abelii	86.96	0.00e+00	1843.00
IUUC-Pca-100855	Procavia capensis	83.49	0.00e+00	1267.00
IUUC-Pva-102506	Pteropus vampyrus	79.85	0.00e+00	1620.00
IUUC-Rno-105242	Rattus norvegicus	85.82	0.00e+00	1860.00
IUUC-Sha-107186	Sarcophilus harrisii	86.15	0.00e+00	1163.00
IUUC-Sar-113612	Sorex araneus	88.27	0.00e+00	683.00
IUUC-Ssc-115473	Sus scrofa	86.96	0.00e+00	1837.00
IUUC-Tgu-116974	Taeniopygia guttata	96.96	0.00e+00	2020.00
IUUC-Tru-118077	Takifugu rubripes	64.21	0.00e+00	1308.00
IUUC-Tsy-119619	Tarsius syrichta	76.69	0.00e+00	1626.00
IUUC-Tni-120807	Tetraodon nigroviridis	64.72	0.00e+00	1333.00
IUUC-Tbe-127640	Tupaia belangeri	83.25	0.00e+00	1718.00
IUUC-Ttr-129172	Tursiops truncatus	86.58	0.00e+00	1830.00
IUUC-Vpa-130442	Vicugna pacos	73.19	0.00e+00	1485.00
IUUC-Xtr-132194	Xenopus tropicalis	70.85	0.00e+00	1407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence