iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027847

UUCD1 version

UUC-DaR-01265

Ensembl Protein ID

ENSDARP00000012386.7

UniProt Accession

Q6TEM9; Q1LUH7; Q6P0B8; Q6T628; Q7ZVI9; MYLIA_DANRE

Genbank Protein ID

AAQ98868.1; AAQ97996.1; CAK04866.1; AAH65679.1

Protein Name

E3 ubiquitin-protein ligase MYLIP-A; Myosin regulatory light chain-interacting protein A; RING-type E3 ubiquitin transferase MYLIP-A

Genbank Nucleotide ID

AY434450; AY423020; BX936330; BC065679

Gene Name

mylipa; mir; mylip; si:ch211-266j17.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000008859.7	ENSDART00000013497.7	ENSDARP00000012386.7

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	75.11	0.00e+00	666.00	IUUC-Hsa-046869

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway.

Protein Sequence
(Fasta)

MLCHVTRPDA VVMEIEVDAK ANGEDCLNKV CRKLGIIEVD YFGLQFSGSK GENLWLNLRN 60
RISQQMDNLT PCRLRLRVKF FVEPHLILQE QTRHLFFMHV KEDLHRGHLR MCSEQAQELS 120

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Nucleotide Sequence
(Fasta)

GACTGAGAGA AAACAGAAGG ATTGAGGAAA GTGAGCGAGG GCTGATGTAG GGTGTTAAAA 60
GAAGACAACA CTGAGAGCGG TTTGTAGTGT TTTTCGTACA GGACTGGTAG ACCAAAGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0306--Gastrulation
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR019749--Band_41_domain
IPR001370--BIR_rpt
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR000299--FERM_domain
IPR018979--FERM_N
IPR018980--FERM_PH-like_C
IPR011993--PH_dom-like
IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING

PROSITE

PS50057--FERM_3
PS50089--ZF_RING_2

Pfam

PF00373--FERM_M
PF09379--FERM_N

PRINTS

PR00935--BAND41

SMART

SM00295--B41
SM01196--FERM_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007369--P:gastrulation
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dre:335888

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001425	Ailuropoda melanoleuca	75.06	0.00e+00	667.00
IUUC-Apl-003704	Anas platyrhynchos	76.08	0.00e+00	655.00
IUUC-Aca-004645	Anolis carolinensis	75.11	0.00e+00	659.00
IUUC-Ame-011401	Astyanax mexicanus	91.31	0.00e+00	834.00
IUUC-Bta-012752	Bos taurus	72.56	3.00e-166	577.00
IUUC-Cja-019734	Callithrix jacchus	74.32	0.00e+00	699.00
IUUC-Cfa-020145	Canis familiaris	74.02	3.00e-172	597.00
IUUC-Cpo-021436	Cavia porcellus	73.61	6.00e-168	583.00
IUUC-Csa-024248	Chlorocebus sabaeus	75.00	0.00e+00	704.00
IUUC-Cho-024528	Choloepus hoffmanni	66.82	6.00e-164	570.00
IUUC-Cin-025748	Ciona intestinalis	38.95	3.00e-47	182.00
IUUC-Csv-025837	Ciona savignyi	39.96	5.00e-93	335.00
IUUC-Dno-029860	Dasypus novemcinctus	73.23	1.00e-159	555.00
IUUC-Dor-030664	Dipodomys ordii	65.70	1.00e-163	569.00
IUUC-Dse-031509	Dothistroma septosporum	45.28	2.00e-09	58.50
IUUC-Dme-031990	Drosophila melanogaster	31.69	1.00e-36	148.00
IUUC-Ete-032496	Echinops telfairi	63.72	2.00e-123	435.00
IUUC-Eca-033674	Equus caballus	74.67	0.00e+00	711.00
IUUC-Eeu-035048	Erinaceus europaeus	69.51	0.00e+00	640.00
IUUC-Fca-036547	Felis catus	75.30	0.00e+00	667.00
IUUC-Fal-037504	Ficedula albicollis	75.96	0.00e+00	643.00
IUUC-Gmo-038660	Gadus morhua	85.88	4.00e-174	604.00
IUUC-Gga-040123	Gallus gallus	77.03	0.00e+00	687.00
IUUC-Gac-042073	Gasterosteus aculeatus	84.53	0.00e+00	736.00
IUUC-Ggo-045387	Gorilla gorilla	75.00	0.00e+00	706.00
IUUC-Hsa-046869	Homo sapiens	75.23	0.00e+00	709.00
IUUC-Itr-047917	Ictidomys tridecemlineatus	73.20	0.00e+00	685.00
IUUC-Lch-049990	Latimeria chalumnae	76.80	0.00e+00	723.00
IUUC-Loc-051908	Lepisosteus oculatus	76.56	0.00e+00	725.00
IUUC-Lma-053223	Leptosphaeria maculans	41.54	3.00e-09	58.50
IUUC-Laf-053915	Loxodonta africana	74.55	0.00e+00	690.00
IUUC-Mcc-054865	Macaca mulatta	74.77	0.00e+00	703.00
IUUC-Meu-056826	Macropus eugenii	68.83	2.00e-59	223.00
IUUC-Mga-059827	Meleagris gallopavo	75.31	1.00e-176	612.00
IUUC-Mmr-060734	Microcebus murinus	75.34	0.00e+00	709.00
IUUC-Mdo-062988	Monodelphis domestica	74.22	0.00e+00	711.00
IUUC-Mmu-064415	Mus musculus	74.77	0.00e+00	674.00
IUUC-Mpu-066118	Mustela putorius furo	74.14	7.00e-169	586.00
IUUC-Mlu-067131	Myotis lucifugus	75.11	0.00e+00	687.00
IUUC-Nle-070112	Nomascus leucogenys	75.23	0.00e+00	705.00
IUUC-Opr-071193	Ochotona princeps	73.06	0.00e+00	657.00
IUUC-Ont-072635	Oreochromis niloticus	83.61	0.00e+00	773.00
IUUC-Oan-073266	Ornithorhynchus anatinus	73.38	0.00e+00	642.00
IUUC-Ocu-074903	Oryctolagus cuniculus	72.65	0.00e+00	677.00
IUUC-Ola-087533	Oryzias latipes	82.07	0.00e+00	723.00
IUUC-Oga-087979	Otolemur garnettii	76.01	0.00e+00	716.00
IUUC-Oar-089747	Ovis aries	73.73	0.00e+00	644.00
IUUC-Ptr-090732	Pan troglodytes	75.23	0.00e+00	707.00
IUUC-Pan-092032	Papio anubis	75.00	0.00e+00	704.00
IUUC-Psi-093296	Pelodiscus sinensis	74.52	0.00e+00	658.00
IUUC-Pma-094351	Petromyzon marinus	50.28	4.00e-37	147.00
IUUC-Pno-094968	Phaeosphaeria nodorum	34.72	1.00e-08	56.60
IUUC-Pfo-097183	Poecilia formosa	80.71	0.00e+00	717.00
IUUC-Pab-098177	Pongo abelii	75.00	0.00e+00	705.00
IUUC-Pca-100734	Procavia capensis	74.32	0.00e+00	692.00
IUUC-Pva-102778	Pteropus vampyrus	74.64	0.00e+00	672.00
IUUC-Pte-104027	Pyrenophora teres	38.46	9.00e-09	56.60
IUUC-Rno-106039	Rattus norvegicus	74.55	0.00e+00	700.00
IUUC-Sha-106869	Sarcophilus harrisii	74.34	0.00e+00	664.00
IUUC-Sar-113587	Sorex araneus	54.20	8.00e-121	427.00
IUUC-Ssc-116212	Sus scrofa	74.55	0.00e+00	696.00
IUUC-Tgu-116871	Taeniopygia guttata	75.72	0.00e+00	641.00
IUUC-Tru-117925	Takifugu rubripes	84.38	0.00e+00	776.00
IUUC-Tsy-118815	Tarsius syrichta	73.14	0.00e+00	637.00
IUUC-Tni-120007	Tetraodon nigroviridis	81.60	0.00e+00	740.00
IUUC-Tbe-127381	Tupaia belangeri	71.10	8.00e-152	529.00
IUUC-Ttr-129025	Tursiops truncatus	64.83	9.00e-152	530.00
IUUC-Uma-129528	Ustilago maydis	29.03	3.00e-03	37.40
IUUC-Vpa-130164	Vicugna pacos	59.42	1.00e-139	489.00
IUUC-Xtr-132800	Xenopus tropicalis	73.32	0.00e+00	667.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence