iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089916

Ensembl Protein ID

ENSOARP00000017121.1

UniProt Accession

W5Q333; W5Q333_SHEEP

Genbank Protein ID

ENSOARP00000017121

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01031545

Gene Name

USP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015942.1	ENSOART00000017362.1	ENSOARP00000017121.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-98	329.9	269	598

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l+++  +  +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+
   Q: 269  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYLRDLSHS--SRAHTALMEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFVGYN 355
           9*****************************8888888887..57999**************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qqDaqEfl+flld+l++e+++ +  pk+++e+ d+   +++    ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dlsl
   Q: 356  QQDAQEFLRFLLDGLHNEVNRVTARPKSNTENLDHLPDDEKgrqMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 444
           *******************99888888777777744444447779******************************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls 262
           p+ ++    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k++  v+fpl+ Ldl+
   Q: 445  PITKRGYP-EVTLMDCMRLFTKEDVLDGDEKPTCCHCRARKRCIKKFSIQRFPKILVLHLKRF--SESRIRTSKLTAFVNFPLRdLDLR 530
           ****9976.779***************************************************..88899******************* PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +f +++++    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+V++++ ++v +   s+aY+lfY+
   Q: 531  EFASENTN----HAVYNLYAVSNHSGTTMGGHYTAYCRSpVTGEWHTFNDSSVSPMSSSQVRT---SDAYLLFYE 598
           ****9553....78*************************44666*******************...********8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSQLSSTLKR YTESARYTDA PFTKPSYGTY TPSSYGTNLA ASFLEKEKLG FKPSPPTSYL 60
TRPRTYGPPS ILDYDRGRPL LRPDIIGGGK RAESQTRGSE RPSGSGLSGG SGFPYGVTTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCATGAGGC TCCCAGTCCC CACCGAGTGC CGCCCTGAAG GATGTCCCAG CTCTCCTCCA 60
CTCTGAAGCG CTACACAGAA TCGGCCCGTT ATACAGATGC GCCTTTCACC AAACCGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005938--C:cell cortex
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101109478

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001988	Ailuropoda melanoleuca	93.73	0.00e+00	1075.00
IUUC-Aca-005132	Anolis carolinensis	61.00	0.00e+00	704.00
IUUC-Ame-011102	Astyanax mexicanus	74.93	8.00e-150	523.00
IUUC-Bta-012529	Bos taurus	98.35	0.00e+00	1094.00
IUUC-Cja-019016	Callithrix jacchus	88.20	0.00e+00	998.00
IUUC-Cfa-020714	Canis familiaris	93.23	0.00e+00	1092.00
IUUC-Cpo-021727	Cavia porcellus	88.61	0.00e+00	1009.00
IUUC-Csa-023071	Chlorocebus sabaeus	96.83	0.00e+00	655.00
IUUC-Cin-025797	Ciona intestinalis	50.43	8.00e-94	336.00
IUUC-Csv-026132	Ciona savignyi	51.48	1.00e-97	350.00
IUUC-Dre-027872	Danio rerio	74.48	3.00e-165	574.00
IUUC-Dno-029329	Dasypus novemcinctus	92.57	0.00e+00	1077.00
IUUC-Dor-030574	Dipodomys ordii	91.42	0.00e+00	1021.00
IUUC-Dme-032208	Drosophila melanogaster	47.31	7.00e-83	301.00
IUUC-Ete-032725	Echinops telfairi	81.60	3.00e-178	618.00
IUUC-Eca-033361	Equus caballus	94.22	0.00e+00	1082.00
IUUC-Eeu-035272	Erinaceus europaeus	76.74	0.00e+00	695.00
IUUC-Fca-036497	Felis catus	93.56	0.00e+00	1078.00
IUUC-Fal-036766	Ficedula albicollis	64.22	0.00e+00	676.00
IUUC-Gmo-039129	Gadus morhua	61.28	1.00e-127	449.00
IUUC-Gga-040889	Gallus gallus	81.13	3.00e-148	518.00
IUUC-Gac-042475	Gasterosteus aculeatus	69.54	3.00e-141	494.00
IUUC-Ggo-044814	Gorilla gorilla	91.09	2.00e-169	588.00
IUUC-Hsa-045937	Homo sapiens	89.77	0.00e+00	1003.00
IUUC-Itr-048171	Ictidomys tridecemlineatus	91.67	0.00e+00	1070.00
IUUC-Lch-050527	Latimeria chalumnae	61.52	0.00e+00	641.00
IUUC-Loc-052697	Lepisosteus oculatus	78.29	2.00e-162	565.00
IUUC-Laf-054167	Loxodonta africana	85.55	0.00e+00	1010.00
IUUC-Mcc-055584	Macaca mulatta	90.76	0.00e+00	1043.00
IUUC-Meu-056542	Macropus eugenii	86.49	0.00e+00	938.00
IUUC-Mga-060020	Meleagris gallopavo	60.32	2.00e-180	625.00
IUUC-Mmr-060989	Microcebus murinus	92.74	0.00e+00	1066.00
IUUC-Mdo-062761	Monodelphis domestica	86.00	0.00e+00	940.00
IUUC-Mmu-063710	Mus musculus	89.01	0.00e+00	1029.00
IUUC-Mpu-066573	Mustela putorius furo	94.06	0.00e+00	1082.00
IUUC-Nle-070013	Nomascus leucogenys	89.93	0.00e+00	992.00
IUUC-Opr-070907	Ochotona princeps	90.12	0.00e+00	994.00
IUUC-Ont-071944	Oreochromis niloticus	80.98	5.00e-165	573.00
IUUC-Oan-073105	Ornithorhynchus anatinus	78.70	8.00e-147	513.00
IUUC-Ocu-073941	Oryctolagus cuniculus	91.93	0.00e+00	1046.00
IUUC-Ola-087412	Oryzias latipes	74.73	6.00e-155	540.00
IUUC-Oga-088973	Otolemur garnettii	92.74	0.00e+00	1066.00
IUUC-Ptr-090998	Pan troglodytes	90.10	0.00e+00	1011.00
IUUC-Pan-092686	Papio anubis	90.92	0.00e+00	1045.00
IUUC-Psi-093284	Pelodiscus sinensis	69.09	1.00e-123	435.00
IUUC-Pma-094462	Petromyzon marinus	65.24	4.00e-75	273.00
IUUC-Pno-094986	Phaeosphaeria nodorum	31.82	2.00e-40	160.00
IUUC-Pfo-097352	Poecilia formosa	78.93	2.00e-170	592.00
IUUC-Pab-098688	Pongo abelii	83.00	0.00e+00	904.00
IUUC-Pca-100205	Procavia capensis	92.51	0.00e+00	642.00
IUUC-Pva-103188	Pteropus vampyrus	92.57	0.00e+00	1032.00
IUUC-Rno-105853	Rattus norvegicus	89.64	0.00e+00	1059.00
IUUC-Sha-107237	Sarcophilus harrisii	85.67	0.00e+00	936.00
IUUC-Sar-113103	Sorex araneus	89.91	4.00e-173	600.00
IUUC-Ssc-115955	Sus scrofa	94.55	0.00e+00	1088.00
IUUC-Tgu-116894	Taeniopygia guttata	69.92	1.00e-177	615.00
IUUC-Tru-117703	Takifugu rubripes	65.50	3.00e-128	451.00
IUUC-Tsy-118879	Tarsius syrichta	93.50	0.00e+00	800.00
IUUC-Tni-119866	Tetraodon nigroviridis	73.30	2.00e-159	555.00
IUUC-Tbe-127367	Tupaia belangeri	85.85	0.00e+00	677.00
IUUC-Ttr-128773	Tursiops truncatus	91.75	0.00e+00	1060.00
IUUC-Vpa-130402	Vicugna pacos	83.99	0.00e+00	806.00
IUUC-Xtr-132658	Xenopus tropicalis	56.94	6.00e-177	613.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence