iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.20e-06	27.6	12	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDVRCPWCR 55
           9*****8888555***************999....99**********8 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

Protein Sequence
(Fasta)

METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGITKL 60
PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER TLLPGDMGCR 120

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Nucleotide Sequence
(Fasta)

CAGTGCTTGG GTCTCTGGGG GTGGCACCAA AAGCTCCCGC TCAGTGTCCG GCGCCTGGCG 60
GCGGGTGTCC GAGCGTGGAC TCGGAGGGCA GCCAGGCAGG TGGAGGGCGC CGCCTGAAGC 120

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Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

rno:293561

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001569	Ailuropoda melanoleuca	97.04	3.00e-115	406.00
IUUC-Aca-004700	Anolis carolinensis	94.09	3.00e-111	393.00
IUUC-Ame-011661	Astyanax mexicanus	55.39	5.00e-50	190.00
IUUC-Cja-019799	Callithrix jacchus	96.55	4.00e-106	376.00
IUUC-Cfa-020144	Canis familiaris	95.07	9.00e-100	355.00
IUUC-Cpo-021632	Cavia porcellus	98.52	8.00e-116	409.00
IUUC-Csa-023858	Chlorocebus sabaeus	97.04	2.00e-106	377.00
IUUC-Cho-024669	Choloepus hoffmanni	95.20	9.00e-69	251.00
IUUC-Dre-027881	Danio rerio	58.33	8.00e-57	213.00
IUUC-Dno-029695	Dasypus novemcinctus	90.64	4.00e-98	350.00
IUUC-Dor-030795	Dipodomys ordii	97.54	1.00e-104	371.00
IUUC-Eca-033412	Equus caballus	97.04	5.00e-106	376.00
IUUC-Fca-036256	Felis catus	97.04	8.00e-106	375.00
IUUC-Fal-036943	Ficedula albicollis	93.10	1.00e-102	365.00
IUUC-Gga-040800	Gallus gallus	93.60	4.00e-111	393.00
IUUC-Ggo-045477	Gorilla gorilla	97.54	5.00e-115	406.00
IUUC-Hsa-046568	Homo sapiens	97.54	5.00e-115	406.00
IUUC-Itr-049081	Ictidomys tridecemlineatus	98.03	6.00e-115	405.00
IUUC-Lch-049770	Latimeria chalumnae	84.73	7.00e-96	342.00
IUUC-Loc-052353	Lepisosteus oculatus	86.09	1.00e-59	220.00
IUUC-Laf-054064	Loxodonta africana	96.55	3.00e-113	400.00
IUUC-Mcc-054875	Macaca mulatta	97.04	2.00e-106	377.00
IUUC-Meu-056370	Macropus eugenii	94.61	5.00e-111	392.00
IUUC-Mga-059847	Meleagris gallopavo	93.60	5.00e-111	392.00
IUUC-Mmr-061042	Microcebus murinus	96.55	3.00e-113	400.00
IUUC-Mdo-063047	Monodelphis domestica	94.61	3.00e-111	393.00
IUUC-Mmu-064228	Mus musculus	99.01	1.00e-109	388.00
IUUC-Mlu-067736	Myotis lucifugus	96.06	9.00e-100	355.00
IUUC-Nle-069697	Nomascus leucogenys	97.04	2.00e-106	377.00
IUUC-Ont-072208	Oreochromis niloticus	74.65	3.00e-86	310.00
IUUC-Oan-073566	Ornithorhynchus anatinus	82.76	1.00e-88	318.00
IUUC-Ocu-074089	Oryctolagus cuniculus	95.57	6.00e-101	359.00
IUUC-Ola-087210	Oryzias latipes	69.90	3.00e-75	274.00
IUUC-Oga-088395	Otolemur garnettii	96.55	1.00e-103	368.00
IUUC-Oar-090382	Ovis aries	97.92	6.00e-22	95.10
IUUC-Ptr-091480	Pan troglodytes	97.54	5.00e-115	406.00
IUUC-Pan-091715	Papio anubis	97.04	2.00e-106	377.00
IUUC-Psi-093465	Pelodiscus sinensis	93.10	4.00e-110	390.00
IUUC-Pfo-097259	Poecilia formosa	75.94	4.00e-90	323.00
IUUC-Pab-097769	Pongo abelii	97.54	5.00e-115	406.00
IUUC-Pca-100657	Procavia capensis	96.06	3.00e-112	397.00
IUUC-Pva-102521	Pteropus vampyrus	96.55	4.00e-114	403.00
IUUC-Sha-107197	Sarcophilus harrisii	95.10	3.00e-111	394.00
IUUC-Ssc-116239	Sus scrofa	95.57	8.00e-113	399.00
IUUC-Tru-118315	Takifugu rubripes	74.41	5.00e-82	296.00
IUUC-Tsy-119645	Tarsius syrichta	98.03	4.00e-115	406.00
IUUC-Tni-119835	Tetraodon nigroviridis	73.93	2.00e-86	311.00
IUUC-Tbe-127264	Tupaia belangeri	97.54	4.00e-109	386.00
IUUC-Ttr-128749	Tursiops truncatus	97.04	8.00e-108	382.00
IUUC-Vpa-130808	Vicugna pacos	98.03	1.00e-108	385.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence