iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120196

UUCD1 version

UUC-TeN-00791

Ensembl Protein ID

ENSTNIP00000022824.1

UniProt Accession

H3DQM5; H3DQM5_TETNG

Protein Name

Histone deacetylase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000008890.1	ENSTNIT00000023065.1	ENSTNIP00000022824.1
ENSTNIG00000008890.1	ENSTNIT00000011931.1	ENSTNIP00000011743.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	69.74	0.00e+00	1273.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
801	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Tetraodon nigroviridis

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

VGAQIHPDGV PVCREAPCLK LSQARLPHLA VDVSTAALPM QVPPAATAIL PMDLRVDHHH 60
NHQQQPNHQE QQLQQELVAL KHKQQLQRQL LIAEFQRQHE QLSRQHEIQL QEHIKHQQDL 120

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Nucleotide Sequence
(Fasta)

GTTGGTGCAC AGATTCACCC TGATGGAGTA CCAGTGTGTA GAGAGGCACC ATGTCTCAAG 60
TGCGCTGACC CAACAGAGAA TTTTGTTTGC TTGACCTTGT TGTTTCCTGC TTATTAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	72.97	0.00e+00	1244.00
IUUC-Apl-003250	Anas platyrhynchos	69.11	0.00e+00	1195.00
IUUC-Aca-004668	Anolis carolinensis	79.57	0.00e+00	833.00
IUUC-Bta-013215	Bos taurus	71.01	0.00e+00	1246.00
IUUC-Cja-019816	Callithrix jacchus	70.39	0.00e+00	1274.00
IUUC-Cfa-020861	Canis familiaris	70.82	0.00e+00	1238.00
IUUC-Cpo-021562	Cavia porcellus	69.78	0.00e+00	1266.00
IUUC-Csa-023612	Chlorocebus sabaeus	69.77	0.00e+00	1248.00
IUUC-Csv-026359	Ciona savignyi	53.72	5.00e-92	330.00
IUUC-Dre-028284	Danio rerio	85.53	0.00e+00	850.00
IUUC-Dno-029951	Dasypus novemcinctus	68.87	0.00e+00	1159.00
IUUC-Dor-030362	Dipodomys ordii	61.69	0.00e+00	1023.00
IUUC-Dme-031766	Drosophila melanogaster	57.52	1.00e-150	527.00
IUUC-Fca-036187	Felis catus	73.88	0.00e+00	1286.00
IUUC-Gmo-038473	Gadus morhua	76.09	0.00e+00	751.00
IUUC-Gga-040501	Gallus gallus	70.28	0.00e+00	1238.00
IUUC-Gac-042335	Gasterosteus aculeatus	82.25	0.00e+00	1493.00
IUUC-Ggo-045380	Gorilla gorilla	69.94	0.00e+00	1247.00
IUUC-Hsa-046925	Homo sapiens	70.12	0.00e+00	1267.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	71.42	0.00e+00	1238.00
IUUC-Lch-050325	Latimeria chalumnae	76.85	0.00e+00	791.00
IUUC-Loc-052231	Lepisosteus oculatus	83.67	0.00e+00	819.00
IUUC-Laf-054490	Loxodonta africana	68.42	0.00e+00	1208.00
IUUC-Mcc-055265	Macaca mulatta	69.57	0.00e+00	1252.00
IUUC-Meu-056676	Macropus eugenii	77.27	4.00e-178	618.00
IUUC-Mmr-061633	Microcebus murinus	65.58	0.00e+00	1105.00
IUUC-Mmu-063089	Mus musculus	70.99	0.00e+00	1247.00
IUUC-Mpu-065887	Mustela putorius furo	73.19	0.00e+00	1252.00
IUUC-Mlu-067470	Myotis lucifugus	71.72	0.00e+00	1277.00
IUUC-Nle-069099	Nomascus leucogenys	64.03	0.00e+00	739.00
IUUC-Ont-071613	Oreochromis niloticus	86.75	0.00e+00	872.00
IUUC-Oan-073275	Ornithorhynchus anatinus	69.83	0.00e+00	1245.00
IUUC-Ola-087031	Oryzias latipes	81.45	0.00e+00	1424.00
IUUC-Oga-088201	Otolemur garnettii	67.09	0.00e+00	1147.00
IUUC-Oar-089997	Ovis aries	68.13	0.00e+00	1068.00
IUUC-Ptr-091116	Pan troglodytes	70.30	0.00e+00	1285.00
IUUC-Pan-092132	Papio anubis	70.71	0.00e+00	855.00
IUUC-Psi-093734	Pelodiscus sinensis	80.53	0.00e+00	791.00
IUUC-Pma-094347	Petromyzon marinus	67.89	0.00e+00	667.00
IUUC-Pfo-096293	Poecilia formosa	79.56	0.00e+00	1435.00
IUUC-Pab-098491	Pongo abelii	67.74	0.00e+00	1184.00
IUUC-Pca-101004	Procavia capensis	61.80	2.00e-174	606.00
IUUC-Pva-102961	Pteropus vampyrus	54.81	9.00e-174	603.00
IUUC-Rno-105005	Rattus norvegicus	70.57	0.00e+00	1223.00
IUUC-Sha-107646	Sarcophilus harrisii	82.45	1.00e-161	563.00
IUUC-Ssc-115428	Sus scrofa	71.36	0.00e+00	1239.00
IUUC-Tgu-116776	Taeniopygia guttata	81.97	0.00e+00	825.00
IUUC-Tru-118180	Takifugu rubripes	89.91	0.00e+00	1621.00
IUUC-Tsy-119468	Tarsius syrichta	61.54	3.00e-146	512.00
IUUC-Ttr-128360	Tursiops truncatus	66.04	0.00e+00	750.00
IUUC-Xtr-132956	Xenopus tropicalis	67.19	0.00e+00	1144.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence