iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069505

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01099737

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000001407.1	ENSNLET00000001896.1	ENSNLEP00000001793.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.20e-108	360.9	548	874

Active Site

Position(s)	Description	Evidence
843	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 548  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 631
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 632  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 718
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 719  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 807
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 808  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874
           *****************...8888866666**************************************97 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MEKLHQCYWK SGEPQSDDIE ASRMKRAAAK HLIERYYHQL TEGCGNEACT NEFCASCPTF 60
LRMDNNAAAI KALELYKINA KLCDPHPSKK GASSAYLENS KGAPNNSCSE IKMNKKGARI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAAGC TGCACCAGTG TTATTGGAAG TGAGCCACCA TTTGAATTTG CTAGCTCATG 60
CTGCAGTATT CAGATTAGTG GGCGTTTTGT GATCATATTT TCTGCGATTC AAATCAAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	98.24	0.00e+00	1612.00
IUUC-Atr-003144	Amborella trichopoda	45.80	8.00e-96	343.00
IUUC-Apl-003742	Anas platyrhynchos	91.32	0.00e+00	1587.00
IUUC-Aca-004873	Anolis carolinensis	93.30	0.00e+00	1600.00
IUUC-Ame-011166	Astyanax mexicanus	86.83	0.00e+00	1452.00
IUUC-Bta-013286	Bos taurus	97.13	0.00e+00	1583.00
IUUC-Cja-019707	Callithrix jacchus	99.54	0.00e+00	1684.00
IUUC-Cfa-020154	Canis familiaris	97.70	0.00e+00	1620.00
IUUC-Cpo-021292	Cavia porcellus	97.66	0.00e+00	1602.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	99.65	0.00e+00	1665.00
IUUC-Cho-025059	Choloepus hoffmanni	93.81	0.00e+00	1512.00
IUUC-Cin-025643	Ciona intestinalis	44.91	0.00e+00	714.00
IUUC-Csv-026282	Ciona savignyi	45.10	0.00e+00	673.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	4.00e-101	363.00
IUUC-Dre-027901	Danio rerio	86.23	0.00e+00	1437.00
IUUC-Dno-029320	Dasypus novemcinctus	97.37	0.00e+00	1625.00
IUUC-Dor-030756	Dipodomys ordii	95.41	0.00e+00	744.00
IUUC-Dme-032035	Drosophila melanogaster	42.86	1.00e-165	577.00
IUUC-Eca-033843	Equus caballus	98.01	0.00e+00	1574.00
IUUC-Eeu-035109	Erinaceus europaeus	96.36	0.00e+00	1561.00
IUUC-Fca-036344	Felis catus	95.99	0.00e+00	1618.00
IUUC-Fal-036747	Ficedula albicollis	91.32	0.00e+00	1588.00
IUUC-Gmo-038840	Gadus morhua	63.58	0.00e+00	1103.00
IUUC-Gga-040399	Gallus gallus	91.21	0.00e+00	1586.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.36	0.00e+00	1394.00
IUUC-Ggo-044804	Gorilla gorilla	100.00	0.00e+00	1692.00
IUUC-Hsa-045727	Homo sapiens	100.00	0.00e+00	1692.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	94.50	0.00e+00	1519.00
IUUC-Lch-050197	Latimeria chalumnae	91.01	0.00e+00	1548.00
IUUC-Loc-052743	Lepisosteus oculatus	88.63	0.00e+00	1521.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	4.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	96.08	0.00e+00	1607.00
IUUC-Mcc-054934	Macaca mulatta	99.20	0.00e+00	1666.00
IUUC-Meu-056061	Macropus eugenii	90.26	0.00e+00	1426.00
IUUC-Mga-059271	Meleagris gallopavo	90.71	0.00e+00	1561.00
IUUC-Mmr-061288	Microcebus murinus	98.40	0.00e+00	1659.00
IUUC-Mdo-062975	Monodelphis domestica	95.54	0.00e+00	1603.00
IUUC-Mmu-063674	Mus musculus	95.40	0.00e+00	1576.00
IUUC-Mpu-066568	Mustela putorius furo	98.05	0.00e+00	1646.00
IUUC-Mlu-067522	Myotis lucifugus	88.95	0.00e+00	1497.00
IUUC-Opr-070570	Ochotona princeps	89.77	0.00e+00	1461.00
IUUC-Ont-071527	Oreochromis niloticus	84.65	0.00e+00	1464.00
IUUC-Oan-073446	Ornithorhynchus anatinus	90.59	0.00e+00	1053.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.56	0.00e+00	1626.00
IUUC-Ola-086996	Oryzias latipes	85.51	0.00e+00	1466.00
IUUC-Oga-088261	Otolemur garnettii	98.94	0.00e+00	1629.00
IUUC-Oar-090024	Ovis aries	97.13	0.00e+00	1583.00
IUUC-Ptr-090455	Pan troglodytes	100.00	0.00e+00	1692.00
IUUC-Pan-092509	Papio anubis	98.37	0.00e+00	1522.00
IUUC-Psi-092974	Pelodiscus sinensis	91.43	0.00e+00	1555.00
IUUC-Pma-094643	Petromyzon marinus	71.72	0.00e+00	1259.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	8.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	85.35	0.00e+00	1461.00
IUUC-Pab-097840	Pongo abelii	97.54	0.00e+00	1597.00
IUUC-Pca-100869	Procavia capensis	96.84	0.00e+00	1590.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	667.00
IUUC-Rno-105453	Rattus norvegicus	95.63	0.00e+00	1581.00
IUUC-Sha-107651	Sarcophilus harrisii	95.54	0.00e+00	1603.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	6.00e-116	411.00
IUUC-Sar-113293	Sorex araneus	97.43	0.00e+00	1597.00
IUUC-Ssc-115979	Sus scrofa	97.54	0.00e+00	1598.00
IUUC-Tgu-116901	Taeniopygia guttata	91.32	0.00e+00	1587.00
IUUC-Tru-118368	Takifugu rubripes	86.01	0.00e+00	1462.00
IUUC-Tsy-119516	Tarsius syrichta	94.95	0.00e+00	1518.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.83	0.00e+00	1454.00
IUUC-Tbe-127484	Tupaia belangeri	92.76	0.00e+00	1108.00
IUUC-Ttr-129078	Tursiops truncatus	97.31	0.00e+00	1570.00
IUUC-Vpa-130312	Vicugna pacos	90.05	0.00e+00	1353.00
IUUC-Xtr-132881	Xenopus tropicalis	91.59	0.00e+00	1551.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence