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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046958
UUCD1 version UUC-HoS-00429
Ensembl Protein ID ENSP00000318775.3
UniProt Accession Q9UJX5; A8K8H1; E9PCR4; Q6PCC6; Q9NSH6; APC4_HUMAN
Genbank Protein ID AAF05752.1; BAF85025.1; EAW92839.1; AAH59383.1; CAB89245.1
Protein Name Anaphase-promoting complex subunit 4; Cyclosome subunit 4
Genbank Nucleotide ID AF191338; AK292336; CH471069; BC059383; AL353932
Gene Name ANAPC4; APC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000053900.10 ENST00000315368.7 ENSP00000318775.3
ENSG00000053900.10 ENST00000510092.5 ENSP00000426654.1
ENSG00000053900.10 ENST00000505080.1 ENSP00000426512.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP 60
NENTGKEVTC LAWRPDGKLL AFALADTKKI VLCDVEKPES LHSFSVEAPV SCMHWMEVTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046958|E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCCGACGCCG GAAGTGCCTG GAGCGCGCGA CAGCGGCGGG GCGGGGCGGC CTGGAGGCTG 60
TGGCGCGCGG CCGGCAGAGG GAGGGGAGAG GCCACTGGGG CCGTGTTAGT CTGCCGGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046958|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR024789--APC4
IPR024790--APC4_long_dom
IPR017169--APC4_metazoa
IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
Pfam

PF12896--ANAPC4
PF12894--ANAPC4_WD40
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:29945
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002338 Ailuropoda melanoleuca 96.30 0.00e+00 1518.00
IUUC-Atr-003115 Amborella trichopoda 25.05 2.00e-34 141.00
IUUC-Apl-003682 Anas platyrhynchos 76.64 0.00e+00 1103.00
IUUC-Aca-005052 Anolis carolinensis 77.84 0.00e+00 1185.00
IUUC-Ath-007407 Arabidopsis thaliana 24.56 2.00e-37 151.00
IUUC-Acl-008322 Aspergillus clavatus 36.78 5.00e-04 40.00
IUUC-Afu-008986 Aspergillus fumigatus 22.41 2.00e-05 45.10
IUUC-Ani-009236 Aspergillus nidulans 22.01 9.00e-07 49.30
IUUC-Ang-009689 Aspergillus niger 20.98 1.10e-02 35.40
IUUC-Ate-010504 Aspergillus terreus 22.22 3.00e-11 63.90
IUUC-Ame-011676 Astyanax mexicanus 67.38 0.00e+00 983.00
IUUC-Bgr-012272 Blumeria graminis 21.10 7.00e-09 56.20
IUUC-Bta-013421 Bos taurus 97.15 0.00e+00 1534.00
IUUC-Bdi-014507 Brachypodium distachyon 23.73 5.00e-33 136.00
IUUC-Bol-015675 Brassica oleracea 24.23 5.00e-35 143.00
IUUC-Bra-017735 Brassica rapa 24.83 5.00e-35 143.00
IUUC-Cja-019695 Callithrix jacchus 98.52 0.00e+00 1540.00
IUUC-Cfa-020688 Canis familiaris 97.52 0.00e+00 1529.00
IUUC-Cpo-022263 Cavia porcellus 94.58 0.00e+00 1517.00
IUUC-Csa-023068 Chlorocebus sabaeus 99.38 0.00e+00 1599.00
IUUC-Cho-024289 Choloepus hoffmanni 87.98 3.00e-173 602.00
IUUC-Cin-025329 Ciona intestinalis 28.71 2.00e-50 193.00
IUUC-Dre-028148 Danio rerio 65.73 0.00e+00 932.00
IUUC-Dno-028901 Dasypus novemcinctus 96.63 0.00e+00 936.00
IUUC-Dor-030642 Dipodomys ordii 80.69 0.00e+00 1202.00
IUUC-Dse-031568 Dothistroma septosporum 21.64 8.00e-06 46.20
IUUC-Ete-032229 Echinops telfairi 66.97 2.00e-152 533.00
IUUC-Eca-033983 Equus caballus 97.52 0.00e+00 1566.00
IUUC-Eeu-035203 Erinaceus europaeus 89.85 0.00e+00 1415.00
IUUC-Fca-036269 Felis catus 96.53 0.00e+00 1534.00
IUUC-Fal-036650 Ficedula albicollis 80.00 0.00e+00 1217.00
IUUC-Fso-038390 Fusarium solani 21.50 6.00e-12 66.60
IUUC-Gmo-039161 Gadus morhua 68.05 0.00e+00 981.00
IUUC-Gga-041031 Gallus gallus 79.40 1.00e-89 322.00
IUUC-Gac-042424 Gasterosteus aculeatus 67.47 0.00e+00 991.00
IUUC-Gma-043402 Glycine max 25.00 1.00e-38 155.00
IUUC-Ggo-045199 Gorilla gorilla 87.20 0.00e+00 1273.00
IUUC-Itr-049044 Ictidomys tridecemlineatus 96.78 0.00e+00 1558.00
IUUC-Kpa-049219 Komagataella pastoris 23.50 7.00e-07 49.30
IUUC-Lpe-050838 Leersia perrieri 24.17 3.00e-37 150.00
IUUC-Loc-052502 Lepisosteus oculatus 69.50 0.00e+00 1003.00
IUUC-Laf-054361 Loxodonta africana 96.53 0.00e+00 1554.00
IUUC-Mcc-054893 Macaca mulatta 98.76 0.00e+00 1582.00
IUUC-Mor-056950 Magnaporthe oryzae 21.22 1.00e-13 72.00
IUUC-Mtr-058751 Medicago truncatula 24.09 5.00e-37 149.00
IUUC-Mga-059591 Meleagris gallopavo 76.92 0.00e+00 1092.00
IUUC-Mvi-060263 Microbotryum violaceum 23.27 1.00e-03 39.30
IUUC-Mmr-060603 Microcebus murinus 98.51 0.00e+00 1582.00
IUUC-Mdo-062137 Monodelphis domestica 81.43 0.00e+00 1219.00
IUUC-Mmu-064358 Mus musculus 93.44 0.00e+00 1476.00
IUUC-Mac-064679 Musa acuminata 24.49 2.00e-20 94.00
IUUC-Mpu-065751 Mustela putorius furo 97.40 0.00e+00 1562.00
IUUC-Mlu-067502 Myotis lucifugus 96.84 0.00e+00 1489.00
IUUC-Nfi-068257 Neosartorya fischeri 19.87 2.00e-06 48.50
IUUC-Nle-069134 Nomascus leucogenys 99.75 0.00e+00 1602.00
IUUC-Opr-071225 Ochotona princeps 86.17 0.00e+00 1336.00
IUUC-Ont-072232 Oreochromis niloticus 68.00 0.00e+00 993.00
IUUC-Oan-073358 Ornithorhynchus anatinus 80.16 0.00e+00 1208.00
IUUC-Oba-075232 Oryza barthii 23.67 7.00e-34 139.00
IUUC-Oin-079188 Oryza indica 23.57 5.00e-30 126.00
IUUC-Opu-083725 Oryza punctata 24.12 7.00e-36 145.00
IUUC-Osa-086145 Oryza sativa 30.58 2.00e-12 64.70
IUUC-Ola-086672 Oryzias latipes 66.85 0.00e+00 959.00
IUUC-Oga-088691 Otolemur garnettii 98.15 0.00e+00 1550.00
IUUC-Oar-089607 Ovis aries 97.66 0.00e+00 1497.00
IUUC-Ptr-090893 Pan troglodytes 99.88 0.00e+00 1560.00
IUUC-Pan-092793 Papio anubis 99.26 0.00e+00 1590.00
IUUC-Psi-093143 Pelodiscus sinensis 77.87 0.00e+00 1162.00
IUUC-Pma-094645 Petromyzon marinus 56.17 8.00e-154 536.00
IUUC-Pno-094772 Phaeosphaeria nodorum 18.43 3.00e-03 37.40
IUUC-Ppa-095509 Physcomitrella patens 24.81 8.00e-28 119.00
IUUC-Pfo-096716 Poecilia formosa 64.82 0.00e+00 931.00
IUUC-Pab-098772 Pongo abelii 99.53 0.00e+00 1273.00
IUUC-Pop-099247 Populus trichocarpa 25.38 9.00e-39 155.00
IUUC-Pca-101083 Procavia capensis 90.21 0.00e+00 1150.00
IUUC-Ppe-101619 Prunus persica 24.64 3.00e-22 100.00
IUUC-Pva-103168 Pteropus vampyrus 95.44 0.00e+00 1398.00
IUUC-Rno-105693 Rattus norvegicus 93.69 0.00e+00 1477.00
IUUC-Sha-106567 Sarcophilus harrisii 81.57 0.00e+00 1211.00
IUUC-Sja-107773 Schizosaccharomyces japonicus 22.33 3.00e-10 60.80
IUUC-Spo-108176 Schizosaccharomyces pombe 22.27 2.00e-05 45.10
IUUC-Ssl-108414 Sclerotinia sclerotiorum 23.70 1.00e-10 62.00
IUUC-Smo-108903 Selaginella moellendorffii 31.33 3.00e-10 59.70
IUUC-Sit-110467 Setaria italica 23.54 2.00e-30 127.00
IUUC-Sly-111734 Solanum lycopersicum 25.95 1.00e-37 151.00
IUUC-Sar-112993 Sorex araneus 77.45 0.00e+00 885.00
IUUC-Sbi-114693 Sorghum bicolor 23.82 3.00e-36 147.00
IUUC-Ssc-115237 Sus scrofa 96.91 0.00e+00 1518.00
IUUC-Tgu-116897 Taeniopygia guttata 79.49 0.00e+00 1221.00
IUUC-Tru-117802 Takifugu rubripes 64.62 0.00e+00 928.00
IUUC-Tsy-119583 Tarsius syrichta 94.38 0.00e+00 1416.00
IUUC-Tni-120268 Tetraodon nigroviridis 77.30 5.00e-136 478.00
IUUC-Tca-121296 Theobroma cacao 25.05 1.00e-37 151.00
IUUC-Tae-123786 Triticum aestivum 24.17 2.00e-32 134.00
IUUC-Tbe-127711 Tupaia belangeri 88.89 0.00e+00 1286.00
IUUC-Ttr-128537 Tursiops truncatus 94.06 0.00e+00 1487.00
IUUC-Uma-129395 Ustilago maydis 21.94 2.00e-03 38.90
IUUC-Vpa-130111 Vicugna pacos 83.66 0.00e+00 1241.00
IUUC-Vvi-131490 Vitis vinifera 24.47 6.00e-39 155.00
IUUC-Xtr-132380 Xenopus tropicalis 73.07 0.00e+00 1063.00
IUUC-Xma-133597 Xiphophorus maculatus 64.96 0.00e+00 931.00
IUUC-Yli-134609 Yarrowia lipolytica 22.04 2.00e-14 74.30
Created Date 25-Jun-2017

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