iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088700

Ensembl Protein ID

ENSOGAP00000000381.2

UniProt Accession

H0WGE2; H0WGE2_OTOGA

Genbank Protein ID

ENSOGAP00000000381

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03016000

Gene Name

EP300

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000000423.2	ENSOGAT00000000426.2	ENSOGAP00000000381.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	94.99	0.00e+00	3457.00	IUUC-Hsa-046884

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS SELGLTNGGD 60
ISQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQVMASQAQQ NSPGLSLINS 120

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Nucleotide Sequence
(Fasta)

ATGGCCGAGA ATGTGGTGGA ACCGGGGCCG CCTTCAGCCA AGCGGCCTAA ACTCTCATCT 60
CCGGCCCTTT CGGCATCGGC CAGCGATGGC ACAGGTTAGT TTCGGGAGCC CCTACCTTCC 120

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Sequence Source

Ensembl

Keyword

KW-0012--Acyltransferase
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ

Gene Ontology

GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005667--C:transcription factor complex
GO:0031490--F:chromatin DNA binding
GO:0003684--F:damaged DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0097157--F:pre-mRNA intronic binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0009887--P:animal organ morphogenesis
GO:0030183--P:B cell differentiation
GO:0034644--P:cellular response to UV
GO:0007623--P:circadian rhythm
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0043969--P:histone H2B acetylation
GO:0043967--P:histone H4 acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030324--P:lung development
GO:0010742--P:macrophage derived foam cell differentiation
GO:0035855--P:megakaryocyte development
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030220--P:platelet formation
GO:0043923--P:positive regulation by host of viral transcription
GO:0032092--P:positive regulation of protein binding
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0050821--P:protein stabilization
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0090043--P:regulation of tubulin deacetylation
GO:0043627--P:response to estrogen
GO:0001666--P:response to hypoxia
GO:0007519--P:skeletal muscle tissue development
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002027	Ailuropoda melanoleuca	96.85	0.00e+00	1937.00
IUUC-Aca-005040	Anolis carolinensis	81.61	0.00e+00	1855.00
IUUC-Ame-011395	Astyanax mexicanus	84.71	0.00e+00	1469.00
IUUC-Bta-012649	Bos taurus	94.72	0.00e+00	2024.00
IUUC-Cel-018691	Caenorhabditis elegans	51.00	0.00e+00	842.00
IUUC-Cja-019649	Callithrix jacchus	94.45	0.00e+00	2130.00
IUUC-Cfa-020764	Canis familiaris	97.84	0.00e+00	1811.00
IUUC-Cpo-022345	Cavia porcellus	90.77	0.00e+00	3344.00
IUUC-Cre-022852	Chlamydomonas reinhardtii	35.09	3.00e-65	243.00
IUUC-Csa-023866	Chlorocebus sabaeus	96.21	0.00e+00	2075.00
IUUC-Cho-024951	Choloepus hoffmanni	96.94	0.00e+00	1234.00
IUUC-Csv-026122	Ciona savignyi	65.08	0.00e+00	677.00
IUUC-Ete-032979	Echinops telfairi	91.25	0.00e+00	1923.00
IUUC-Eca-034048	Equus caballus	97.36	0.00e+00	2073.00
IUUC-Fca-035891	Felis catus	96.63	0.00e+00	2050.00
IUUC-Fal-037585	Ficedula albicollis	85.47	0.00e+00	1912.00
IUUC-Gmo-039348	Gadus morhua	87.23	0.00e+00	1442.00
IUUC-Gga-040916	Gallus gallus	85.08	0.00e+00	1925.00
IUUC-Gac-041642	Gasterosteus aculeatus	87.58	0.00e+00	1417.00
IUUC-Ggo-045189	Gorilla gorilla	95.93	0.00e+00	2075.00
IUUC-Hsa-046884	Homo sapiens	96.07	0.00e+00	2075.00
IUUC-Hvu-047619	Hordeum vulgare	37.40	1.00e-67	252.00
IUUC-Itr-048564	Ictidomys tridecemlineatus	98.09	0.00e+00	1885.00
IUUC-Laf-054423	Loxodonta africana	95.94	0.00e+00	2214.00
IUUC-Mcc-054847	Macaca mulatta	96.28	0.00e+00	2081.00
IUUC-Meu-056217	Macropus eugenii	84.39	0.00e+00	1947.00
IUUC-Mga-059250	Meleagris gallopavo	81.48	0.00e+00	1949.00
IUUC-Mmr-061496	Microcebus murinus	96.63	0.00e+00	2091.00
IUUC-Mdo-062478	Monodelphis domestica	85.76	0.00e+00	2086.00
IUUC-Mmu-063456	Mus musculus	96.06	0.00e+00	1912.00
IUUC-Mac-064767	Musa acuminata	39.60	3.00e-75	277.00
IUUC-Mpu-065963	Mustela putorius furo	94.60	0.00e+00	1891.00
IUUC-Mlu-067185	Myotis lucifugus	96.55	0.00e+00	1907.00
IUUC-Nle-069907	Nomascus leucogenys	96.17	0.00e+00	1873.00
IUUC-Opr-070324	Ochotona princeps	88.42	0.00e+00	1195.00
IUUC-Ont-072211	Oreochromis niloticus	78.55	0.00e+00	1458.00
IUUC-Oan-073723	Ornithorhynchus anatinus	89.37	0.00e+00	1870.00
IUUC-Ocu-074707	Oryctolagus cuniculus	96.70	0.00e+00	1898.00
IUUC-Oba-075590	Oryza barthii	33.52	7.00e-103	369.00
IUUC-Ogu-078580	Oryza glumaepatula	33.38	4.00e-103	370.00
IUUC-Ome-081615	Oryza meridionalis	33.52	7.00e-103	369.00
IUUC-Oni-082636	Oryza nivara	33.52	7.00e-103	369.00
IUUC-Opu-084073	Oryza punctata	32.97	1.00e-99	358.00
IUUC-Oru-084994	Oryza rufipogon	33.52	7.00e-103	369.00
IUUC-Olu-087701	Ostreococcus lucimarinus	35.19	1.00e-61	231.00
IUUC-Oar-089787	Ovis aries	92.12	0.00e+00	2017.00
IUUC-Ptr-091620	Pan troglodytes	95.24	0.00e+00	2076.00
IUUC-Pan-092166	Papio anubis	95.24	0.00e+00	2101.00
IUUC-Psi-093992	Pelodiscus sinensis	87.49	0.00e+00	1883.00
IUUC-Ppa-095569	Physcomitrella patens	37.97	1.00e-70	262.00
IUUC-Pfo-097342	Poecilia formosa	85.01	0.00e+00	1384.00
IUUC-Pab-098235	Pongo abelii	96.00	0.00e+00	2074.00
IUUC-Pop-098947	Populus trichocarpa	40.00	1.00e-73	272.00
IUUC-Pca-100780	Procavia capensis	89.21	0.00e+00	1459.00
IUUC-Pva-103071	Pteropus vampyrus	95.73	0.00e+00	2208.00
IUUC-Sha-106736	Sarcophilus harrisii	84.04	0.00e+00	2772.00
IUUC-Smo-109420	Selaginella moellendorffii	38.01	5.00e-71	263.00
IUUC-Sar-113162	Sorex araneus	94.38	0.00e+00	850.00
IUUC-Ssc-116077	Sus scrofa	95.93	0.00e+00	2114.00
IUUC-Tgu-116872	Taeniopygia guttata	85.76	0.00e+00	1938.00
IUUC-Tsy-119451	Tarsius syrichta	95.37	0.00e+00	1335.00
IUUC-Tca-121835	Theobroma cacao	39.14	4.00e-73	270.00
IUUC-Tur-126284	Triticum urartu	37.66	4.00e-68	253.00
IUUC-Tbe-127772	Tupaia belangeri	87.35	0.00e+00	1303.00
IUUC-Ttr-128325	Tursiops truncatus	96.61	0.00e+00	1460.00
IUUC-Vpa-130766	Vicugna pacos	93.86	0.00e+00	1334.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence