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Tag Content
UUCD2 ID IUUC-Mlu-067584
UUCD1 version UUC-MyL-00158
Ensembl Protein ID ENSMLUP00000002968.2
UniProt Accession G1NZR5; G1NZR5_MYOLU
Genbank Protein ID ENSMLUP00000002968
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPE02001222
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000003265.2 ENSMLUT00000003265.2 ENSMLUP00000002968.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.20e-127 425.2 421 756
Active Site
Position(s) Description Evidence
725 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 421  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 508
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 509  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLSDWKSNTRLKH-CAADSNIVRWFWQAVETFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekL++A+eet gF +
   Q: 682  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLRIAVEETCGFAV 756
           ******************************99999**************************************76 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
MMKTLSINAN PSIFCLFLVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-067584|E3,HECT|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGATGAAAA CCTTGTCCAT AAATGCTAAC CCTAGCATTT TTTGTTTGTT TTTAGTATTA 60
TGTGCCAAGA ACCTTGCAAA GAAAGACTTC TTCAGTAAGT AAACACCCAT TTTTGCTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-067584|E3,HECT|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 90.17 0.00e+00 1399.00
IUUC-Apl-004155 Anas platyrhynchos 93.87 0.00e+00 1444.00
IUUC-Aca-005238 Anolis carolinensis 91.78 0.00e+00 1402.00
IUUC-Ame-010901 Astyanax mexicanus 86.75 0.00e+00 1335.00
IUUC-Bta-013221 Bos taurus 89.29 0.00e+00 1343.00
IUUC-Cja-018985 Callithrix jacchus 98.12 0.00e+00 1525.00
IUUC-Cfa-020568 Canis familiaris 97.05 0.00e+00 1488.00
IUUC-Cpo-022531 Cavia porcellus 97.45 0.00e+00 1515.00
IUUC-Csa-024145 Chlorocebus sabaeus 94.24 0.00e+00 1448.00
IUUC-Cho-024963 Choloepus hoffmanni 80.52 0.00e+00 976.00
IUUC-Dre-028341 Danio rerio 87.17 0.00e+00 1345.00
IUUC-Dno-029705 Dasypus novemcinctus 96.56 0.00e+00 1492.00
IUUC-Dme-031740 Drosophila melanogaster 72.02 4.00e-174 605.00
IUUC-Eca-034125 Equus caballus 98.65 0.00e+00 1520.00
IUUC-Fca-035905 Felis catus 95.01 0.00e+00 1439.00
IUUC-Fal-037336 Ficedula albicollis 92.64 0.00e+00 1403.00
IUUC-Gmo-039486 Gadus morhua 76.17 0.00e+00 852.00
IUUC-Gga-040218 Gallus gallus 93.98 0.00e+00 1443.00
IUUC-Gac-041707 Gasterosteus aculeatus 80.90 0.00e+00 1236.00
IUUC-Ggo-045408 Gorilla gorilla 91.91 0.00e+00 1424.00
IUUC-Hsa-045878 Homo sapiens 97.72 0.00e+00 1519.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 97.56 0.00e+00 1499.00
IUUC-Loc-052628 Lepisosteus oculatus 82.07 0.00e+00 1322.00
IUUC-Laf-053644 Loxodonta africana 89.60 0.00e+00 1383.00
IUUC-Mcc-055479 Macaca mulatta 86.60 0.00e+00 1298.00
IUUC-Mga-059723 Meleagris gallopavo 89.66 0.00e+00 1383.00
IUUC-Mdo-063005 Monodelphis domestica 93.70 0.00e+00 1442.00
IUUC-Mmu-063634 Mus musculus 93.97 0.00e+00 1425.00
IUUC-Mpu-065898 Mustela putorius furo 95.14 0.00e+00 1442.00
IUUC-Nle-069033 Nomascus leucogenys 98.38 0.00e+00 1516.00
IUUC-Ont-072265 Oreochromis niloticus 83.47 0.00e+00 1286.00
IUUC-Oan-073621 Ornithorhynchus anatinus 89.19 0.00e+00 1412.00
IUUC-Ocu-073960 Oryctolagus cuniculus 97.03 0.00e+00 1484.00
IUUC-Oga-088579 Otolemur garnettii 97.99 0.00e+00 1523.00
IUUC-Oar-090396 Ovis aries 94.06 0.00e+00 1409.00
IUUC-Ptr-091624 Pan troglodytes 97.72 0.00e+00 1519.00
IUUC-Pan-092479 Papio anubis 97.61 0.00e+00 1533.00
IUUC-Pfo-097203 Poecilia formosa 81.06 0.00e+00 1250.00
IUUC-Pab-097540 Pongo abelii 97.76 0.00e+00 1452.00
IUUC-Pca-100379 Procavia capensis 72.73 0.00e+00 642.00
IUUC-Rno-105396 Rattus norvegicus 94.10 0.00e+00 1428.00
IUUC-Sha-107216 Sarcophilus harrisii 94.49 0.00e+00 1458.00
IUUC-Sar-113250 Sorex araneus 96.37 0.00e+00 828.00
IUUC-Ssc-116413 Sus scrofa 94.20 0.00e+00 1412.00
IUUC-Tgu-116723 Taeniopygia guttata 93.41 0.00e+00 1411.00
IUUC-Tru-117843 Takifugu rubripes 79.07 0.00e+00 1231.00
IUUC-Tsy-119455 Tarsius syrichta 98.30 0.00e+00 1425.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.31 0.00e+00 1206.00
IUUC-Tbe-127879 Tupaia belangeri 84.42 0.00e+00 1249.00
IUUC-Ttr-128423 Tursiops truncatus 96.88 0.00e+00 1434.00
IUUC-Xtr-132237 Xenopus tropicalis 85.96 0.00e+00 1358.00
Created Date 25-Jun-2017

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