iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093618

Ensembl Protein ID

ENSPSIP00000017433.1

UniProt Accession

K7GAX2; K7GAX2_PELSI

Genbank Protein ID

ENSPSIP00000017433

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01015229

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000015343.1	ENSPSIT00000017512.1	ENSPSIP00000017433.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-132	441.3	971	1300

Active Site

Position(s)	Description	Evidence
1270	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 971  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1057
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd e+y+sl +i+en   d +e  ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv
   Q: 1058 FFIRPFYKMMLQKPITLHDMESVDGEYYNSLRWILEN---DPTE--LDLRFVVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLV 1139
           ***********************************99...6666..79*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k  tkyk+gy+ ++++iqwFw+++ +++se+r ++
   Q: 1140 IQWRFVSRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLYTKYKNGYSINHQVIQWFWKAVLMMDSEKRIRL 1226
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 1227 LQFVTGTSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLLIAIENTQGFD 1300
           *************************************************************************8 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MARRLRLHFA ARRSNTDPLS ETSGDGLDSN IHVYFQRPSQ NSAPDIIEMK LTPRQAGFPT 60
TMQEIINQQQ HSTVSSLQKN NKKSTSLQIS LQSRRYSECF QSDAVVASED PFISVGNEGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACGAC GGTTAAGATT GCATTTTGCA GCCCGAAGAA GCAACACTGA TCCGTTATCA 60
GAAACCTCTG GCGATGGTTT GGATAGTAAC ATTCATGTGT ATTTCCAAAG ACCTTCACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	68.44	0.00e+00	1720.00
IUUC-Apl-003886	Anas platyrhynchos	81.95	0.00e+00	1359.00
IUUC-Ame-011138	Astyanax mexicanus	83.92	0.00e+00	853.00
IUUC-Bta-012453	Bos taurus	68.19	0.00e+00	1678.00
IUUC-Cja-019034	Callithrix jacchus	82.30	0.00e+00	1256.00
IUUC-Cfa-020258	Canis familiaris	68.82	0.00e+00	1691.00
IUUC-Cpo-021648	Cavia porcellus	79.75	0.00e+00	1321.00
IUUC-Csa-023334	Chlorocebus sabaeus	83.48	0.00e+00	1362.00
IUUC-Cin-025157	Ciona intestinalis	57.07	0.00e+00	874.00
IUUC-Dre-027924	Danio rerio	68.31	0.00e+00	919.00
IUUC-Dno-029159	Dasypus novemcinctus	79.76	0.00e+00	1201.00
IUUC-Dme-032166	Drosophila melanogaster	67.84	0.00e+00	720.00
IUUC-Ete-032409	Echinops telfairi	76.94	0.00e+00	1090.00
IUUC-Eca-033441	Equus caballus	82.73	0.00e+00	1318.00
IUUC-Eeu-034546	Erinaceus europaeus	68.46	0.00e+00	1061.00
IUUC-Fca-036384	Felis catus	68.34	0.00e+00	1705.00
IUUC-Fal-037547	Ficedula albicollis	89.19	0.00e+00	1411.00
IUUC-Gmo-039679	Gadus morhua	68.15	0.00e+00	1090.00
IUUC-Gga-040524	Gallus gallus	90.93	0.00e+00	1416.00
IUUC-Hsa-046479	Homo sapiens	68.47	0.00e+00	1713.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	73.34	0.00e+00	1092.00
IUUC-Lch-050445	Latimeria chalumnae	60.18	0.00e+00	1479.00
IUUC-Loc-052645	Lepisosteus oculatus	74.20	0.00e+00	1201.00
IUUC-Laf-053638	Loxodonta africana	76.12	0.00e+00	1259.00
IUUC-Mcc-055585	Macaca mulatta	68.97	0.00e+00	1718.00
IUUC-Meu-056897	Macropus eugenii	92.68	2.00e-167	582.00
IUUC-Mga-059362	Meleagris gallopavo	83.72	0.00e+00	1392.00
IUUC-Mmr-061061	Microcebus murinus	69.47	0.00e+00	1728.00
IUUC-Mmu-063318	Mus musculus	72.76	0.00e+00	1167.00
IUUC-Mpu-066567	Mustela putorius furo	82.92	0.00e+00	1382.00
IUUC-Mlu-068148	Myotis lucifugus	67.54	0.00e+00	1679.00
IUUC-Nle-069225	Nomascus leucogenys	68.37	0.00e+00	1708.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.22	0.00e+00	1350.00
IUUC-Ocu-074409	Oryctolagus cuniculus	67.24	0.00e+00	1677.00
IUUC-Oga-088241	Otolemur garnettii	64.44	0.00e+00	1523.00
IUUC-Oar-089797	Ovis aries	83.98	0.00e+00	1381.00
IUUC-Ptr-091629	Pan troglodytes	82.57	0.00e+00	1247.00
IUUC-Pfo-097145	Poecilia formosa	68.94	0.00e+00	1081.00
IUUC-Pab-098394	Pongo abelii	82.61	0.00e+00	1355.00
IUUC-Pca-100568	Procavia capensis	71.76	0.00e+00	1059.00
IUUC-Rno-106095	Rattus norvegicus	72.76	0.00e+00	1169.00
IUUC-Sha-107370	Sarcophilus harrisii	63.18	0.00e+00	1538.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	49.28	2.00e-153	535.00
IUUC-Tgu-117474	Taeniopygia guttata	90.19	0.00e+00	1425.00
IUUC-Tru-117675	Takifugu rubripes	65.87	0.00e+00	1066.00
IUUC-Tbe-127408	Tupaia belangeri	77.54	0.00e+00	1046.00
IUUC-Ttr-128437	Tursiops truncatus	74.96	0.00e+00	1074.00
IUUC-Uma-129332	Ustilago maydis	52.38	5.00e-142	498.00
IUUC-Vpa-130503	Vicugna pacos	78.33	0.00e+00	1176.00
IUUC-Xtr-132431	Xenopus tropicalis	71.08	0.00e+00	1221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence