iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049572

Ensembl Protein ID

ENSLACP00000002534.1

UniProt Accession

H2ZYR3; H2ZYR3_LATCH

Genbank Protein ID

ENSLACP00000002534

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01207453

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000002263.1	ENSLACT00000002554.1	ENSLACP00000002534.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-61	208.5	155	639

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+       ++l++++++ ++ +++++l++lf+ ++ sk+k+v+p++ +++lk++ ++ +
   Q: 155  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNyaspTSAQDLPRNQKERRNLPFMRELRHLFALMVGSKRKYVDPSRAVEILKEAFKS-N 242
           6******************************99999999999999999999*******************************99987.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + ++e+  +++k+ ++ +F+g l +  + +  +++ + +e f +++l
   Q: 243  DSQQQDVSEFTHKLLDWLEDAFHM------------------KAEDERILQRKKNAVVGIFGGGLLEAGVNK--GKQFENTELFGQYPL 311
           **********************33..................224578999***************999875..555667999****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki+ k+efp  L +++
   Q: 312  QVNGFK-----DLHECLEAAMVEGEIES---LHSENSAKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHHKLEFPPVLYMDS 389
           ******.....9**************96...899998754...589*****************************************98 PP
   S: 264  .fcts.................................................................................... 267
            ++ +                                                                                    
   Q: 390  rYMDKnreitrikrdeikrlkehltvlqqrlerylsygsgpkrfpladvlqyalefasskpvctspvedidtnapptaatasqatprcs 478
           68888777777777777777777777777777777777777777777777777777777777777666666666666666666666665 PP
   S: 268  .......peekqke........................................................................... 274
                  +     +                                                                           
   Q: 479  tieqqgpS-----Sstempstpplqrpiihkpftqsrippdlpmhpaprhiteeelrvlegclhrwrtevendtrdlqesitrihrtie 562
           55555550.....0555555555556666666666666666666666666666666666666666666666677777777778888888 PP
   S: 275  .........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                    ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 563  vmysdksmmQVPYRLHAVLVHEGQANAGHYWAYIFDHHQEsWMKYNDISVTKSTWEELERDSFggyrnASAYCLMYI 639
           888888888***************************77778*******************8779************6 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

QHHQTFLNQL REITGINDIQ VLQKALKDSN GNLELAVAFL TAKNAKIPQQ EEASYFQTAH 60
PGNDRYISVG SQADTNVIDL TGDDKDDLQR AIALSLEESN RAFRETGITD EEQAISRVLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCACCATC AGACATTCTT GAACCAGCTG AGAGAGATCA CTGGCATCAA TGACATCCAG 60
GTTTTACAGA AAGCCTTAAA GGTATGGTAC TTGTTATGAG TCGGGATTCT CATGCATTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	77.24	0.00e+00	1707.00
IUUC-Apl-004030	Anas platyrhynchos	81.62	0.00e+00	1837.00
IUUC-Aca-004753	Anolis carolinensis	64.69	0.00e+00	1051.00
IUUC-Ame-010624	Astyanax mexicanus	74.01	0.00e+00	1192.00
IUUC-Bta-013166	Bos taurus	79.50	0.00e+00	1193.00
IUUC-Cel-018346	Caenorhabditis elegans	28.29	3.00e-28	121.00
IUUC-Cja-019150	Callithrix jacchus	78.85	0.00e+00	1756.00
IUUC-Cfa-020649	Canis familiaris	79.39	0.00e+00	1768.00
IUUC-Cpo-021807	Cavia porcellus	77.06	0.00e+00	1763.00
IUUC-Csa-023388	Chlorocebus sabaeus	79.10	0.00e+00	1783.00
IUUC-Cin-025302	Ciona intestinalis	37.12	6.00e-93	334.00
IUUC-Dre-028016	Danio rerio	74.63	0.00e+00	1684.00
IUUC-Dno-029495	Dasypus novemcinctus	77.32	0.00e+00	1764.00
IUUC-Dor-030948	Dipodomys ordii	65.19	0.00e+00	1196.00
IUUC-Fca-035876	Felis catus	79.77	0.00e+00	1213.00
IUUC-Fal-036762	Ficedula albicollis	81.65	0.00e+00	1075.00
IUUC-Gmo-039490	Gadus morhua	71.94	0.00e+00	1589.00
IUUC-Gga-040817	Gallus gallus	84.05	0.00e+00	1904.00
IUUC-Gac-042473	Gasterosteus aculeatus	72.47	0.00e+00	1593.00
IUUC-Ggo-044939	Gorilla gorilla	75.36	0.00e+00	1652.00
IUUC-Hsa-046204	Homo sapiens	79.14	0.00e+00	1197.00
IUUC-Loc-052070	Lepisosteus oculatus	80.11	0.00e+00	1769.00
IUUC-Laf-054426	Loxodonta africana	78.79	0.00e+00	1095.00
IUUC-Mcc-055858	Macaca mulatta	79.12	0.00e+00	1787.00
IUUC-Mga-059808	Meleagris gallopavo	83.42	0.00e+00	1300.00
IUUC-Mmr-060987	Microcebus murinus	79.48	0.00e+00	1764.00
IUUC-Mmu-064245	Mus musculus	77.71	0.00e+00	1220.00
IUUC-Mpu-066304	Mustela putorius furo	79.19	0.00e+00	1768.00
IUUC-Mlu-067139	Myotis lucifugus	79.08	0.00e+00	1249.00
IUUC-Nle-069075	Nomascus leucogenys	79.27	0.00e+00	1200.00
IUUC-Ont-072150	Oreochromis niloticus	73.64	0.00e+00	1698.00
IUUC-Oan-073054	Ornithorhynchus anatinus	74.66	0.00e+00	1623.00
IUUC-Ocu-074102	Oryctolagus cuniculus	77.62	0.00e+00	1764.00
IUUC-Ola-086529	Oryzias latipes	69.85	0.00e+00	1533.00
IUUC-Oga-088939	Otolemur garnettii	79.79	0.00e+00	1214.00
IUUC-Oar-090266	Ovis aries	79.30	0.00e+00	1761.00
IUUC-Ptr-090546	Pan troglodytes	79.27	0.00e+00	1199.00
IUUC-Pan-092311	Papio anubis	79.03	0.00e+00	1785.00
IUUC-Psi-093459	Pelodiscus sinensis	87.30	0.00e+00	1133.00
IUUC-Pfo-096726	Poecilia formosa	73.59	0.00e+00	1679.00
IUUC-Pab-097608	Pongo abelii	76.95	0.00e+00	1695.00
IUUC-Pca-100718	Procavia capensis	67.86	0.00e+00	1202.00
IUUC-Pva-103150	Pteropus vampyrus	72.99	0.00e+00	1255.00
IUUC-Rno-105727	Rattus norvegicus	77.97	0.00e+00	1187.00
IUUC-Sha-107051	Sarcophilus harrisii	76.47	0.00e+00	1652.00
IUUC-Sar-113097	Sorex araneus	71.39	0.00e+00	1568.00
IUUC-Ssc-115877	Sus scrofa	77.66	0.00e+00	1200.00
IUUC-Tgu-117473	Taeniopygia guttata	75.00	0.00e+00	1661.00
IUUC-Tru-118135	Takifugu rubripes	66.40	0.00e+00	1389.00
IUUC-Tsy-119471	Tarsius syrichta	73.83	0.00e+00	1532.00
IUUC-Tni-120139	Tetraodon nigroviridis	72.04	0.00e+00	999.00
IUUC-Tbe-127549	Tupaia belangeri	71.75	0.00e+00	1563.00
IUUC-Ttr-128896	Tursiops truncatus	73.48	0.00e+00	1617.00
IUUC-Vpa-130500	Vicugna pacos	79.78	0.00e+00	1159.00
IUUC-Xtr-132896	Xenopus tropicalis	80.68	0.00e+00	1279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence