• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Eca-033949
UUCD1 version UUC-EqC-00861
Ensembl Protein ID ENSECAP00000005168.1
UniProt Accession F7DEE4; F7DEE4_HORSE
Genbank Protein ID AFK29263.1
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID JN712754
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSECAG00000006481.1 ENSECAT00000007141.1 ENSECAP00000005168.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 6.40e-136 453.3 537 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLSKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP
   
Organism Equus caballus
Protein Sequence
(Fasta)
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Eca-033949|E3,HECT|Equus caballus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGTCTTGCA GTTTCCTGGT GATGACATGG CATCTGCCAG CTCCAGCCGG GCAGGAGTGG 60
CCCTGCCTTT TGAGAAGTCT CAGCTCACTT TGAAAGGTGA GTGGCACAGT GAGAAGTGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Eca-033949|E3,HECT|Equus caballus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
KEGG ecb:100067291
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 97.25 0.00e+00 1658.00
IUUC-Apl-003912 Anas platyrhynchos 76.99 0.00e+00 1244.00
IUUC-Aca-004291 Anolis carolinensis 81.13 0.00e+00 1444.00
IUUC-Bta-013231 Bos taurus 96.44 0.00e+00 1621.00
IUUC-Cel-018299 Caenorhabditis elegans 67.01 0.00e+00 832.00
IUUC-Cja-019455 Callithrix jacchus 95.86 0.00e+00 1685.00
IUUC-Cfa-021017 Canis familiaris 97.70 0.00e+00 1653.00
IUUC-Cpo-021988 Cavia porcellus 95.52 0.00e+00 1664.00
IUUC-Csa-023549 Chlorocebus sabaeus 96.09 0.00e+00 1693.00
IUUC-Dre-028513 Danio rerio 91.59 0.00e+00 1136.00
IUUC-Dno-028976 Dasypus novemcinctus 96.79 0.00e+00 1689.00
IUUC-Dor-030176 Dipodomys ordii 92.44 0.00e+00 1503.00
IUUC-Eeu-034529 Erinaceus europaeus 88.86 0.00e+00 1385.00
IUUC-Fca-036236 Felis catus 97.36 0.00e+00 1700.00
IUUC-Fal-036948 Ficedula albicollis 78.55 0.00e+00 1338.00
IUUC-Gmo-038842 Gadus morhua 88.89 0.00e+00 1068.00
IUUC-Gga-040617 Gallus gallus 80.20 0.00e+00 1437.00
IUUC-Gac-041338 Gasterosteus aculeatus 70.04 0.00e+00 1253.00
IUUC-Ggo-045278 Gorilla gorilla 96.32 0.00e+00 1699.00
IUUC-Hsa-046148 Homo sapiens 96.32 0.00e+00 1699.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 97.76 0.00e+00 1119.00
IUUC-Lch-050663 Latimeria chalumnae 78.14 0.00e+00 1385.00
IUUC-Loc-052604 Lepisosteus oculatus 75.60 0.00e+00 1310.00
IUUC-Laf-053944 Loxodonta africana 96.78 0.00e+00 1684.00
IUUC-Mcc-055655 Macaca mulatta 95.98 0.00e+00 1695.00
IUUC-Meu-055953 Macropus eugenii 80.39 0.00e+00 1387.00
IUUC-Mga-060190 Meleagris gallopavo 80.70 0.00e+00 1439.00
IUUC-Mmr-060896 Microcebus murinus 96.30 0.00e+00 1637.00
IUUC-Mdo-062536 Monodelphis domestica 91.74 0.00e+00 1620.00
IUUC-Mmu-064017 Mus musculus 95.17 0.00e+00 1642.00
IUUC-Mpu-066608 Mustela putorius furo 94.38 0.00e+00 1600.00
IUUC-Mlu-067623 Myotis lucifugus 94.03 0.00e+00 1618.00
IUUC-Nle-069496 Nomascus leucogenys 94.03 0.00e+00 1644.00
IUUC-Opr-071054 Ochotona princeps 84.22 0.00e+00 1427.00
IUUC-Ont-071279 Oreochromis niloticus 74.22 0.00e+00 1282.00
IUUC-Oan-073512 Ornithorhynchus anatinus 88.06 0.00e+00 1500.00
IUUC-Ocu-074271 Oryctolagus cuniculus 95.45 0.00e+00 1623.00
IUUC-Ola-087237 Oryzias latipes 69.32 0.00e+00 1231.00
IUUC-Oga-088164 Otolemur garnettii 96.67 0.00e+00 1685.00
IUUC-Oar-089698 Ovis aries 96.78 0.00e+00 1630.00
IUUC-Ptr-091306 Pan troglodytes 95.06 0.00e+00 1665.00
IUUC-Pan-092814 Papio anubis 92.32 0.00e+00 1602.00
IUUC-Pfo-096709 Poecilia formosa 73.75 0.00e+00 1282.00
IUUC-Pab-098494 Pongo abelii 90.50 0.00e+00 1597.00
IUUC-Pca-100596 Procavia capensis 84.40 0.00e+00 1390.00
IUUC-Pva-103154 Pteropus vampyrus 91.80 0.00e+00 1573.00
IUUC-Rno-104954 Rattus norvegicus 94.72 0.00e+00 1414.00
IUUC-Sha-106781 Sarcophilus harrisii 91.63 0.00e+00 1655.00
IUUC-Ssc-116307 Sus scrofa 85.51 0.00e+00 1464.00
IUUC-Tgu-116530 Taeniopygia guttata 76.23 0.00e+00 1196.00
IUUC-Tru-118287 Takifugu rubripes 89.46 0.00e+00 1067.00
IUUC-Tsy-119097 Tarsius syrichta 83.23 0.00e+00 1228.00
IUUC-Tni-120801 Tetraodon nigroviridis 67.71 0.00e+00 1128.00
IUUC-Tbe-127793 Tupaia belangeri 84.25 0.00e+00 1439.00
IUUC-Ttr-128275 Tursiops truncatus 92.18 0.00e+00 1567.00
IUUC-Uma-129332 Ustilago maydis 46.53 2.00e-143 503.00
IUUC-Xtr-132866 Xenopus tropicalis 82.54 0.00e+00 1134.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved