iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054609

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase TRIM21

Genbank Nucleotide ID

JSUE03012850

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000004974.3	ENSMMUT00000007012.3	ENSMMUP00000006591.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.80e-09	36.7	16	55
E3 activity/RING/U-box	9.90e-10	39.5	12	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f + p++  CgH f+++C+ ++      + +   CP+Cr
   Q: 16   CPICLDPFVE-PVSIECGHSFCQECISQV-----GKDGGSVCPVCR 55
           **********.***************999.....7899999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ee  CpI l+++ +Pv +++G+++ +++I +  ++gg+ cPv+rq++  ++l Pn  l +++++
   Q: 12   EEVTCPICLDPFVEPVSIECGHSFCQECISQVGKDGGSVCPVCRQHFLLRNLRPNRQLANMVDN 75
           6889***************************99************************9999875 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKDGGSV CPVCRQHFLL 60
RNLRPNRQLA NMVDNLREIS QEAREGAQEE QCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGGGTG ATGACCAGTG TCAAAGAAAG TAGCCCGGAC TCCCCCGTCA TGTAGATATT 60
TTACCAAACC GGATAATGAA GACATGGGAG GGAGCGCGCA CCCAGGACCA CGGGCTACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

KEGG

mcc:717826

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	79.06	0.00e+00	771.00
IUUC-Aca-004891	Anolis carolinensis	43.90	2.00e-97	349.00
IUUC-Ame-011271	Astyanax mexicanus	32.91	2.00e-62	233.00
IUUC-Bta-013083	Bos taurus	74.20	0.00e+00	686.00
IUUC-Cja-019002	Callithrix jacchus	92.21	0.00e+00	888.00
IUUC-Cfa-020415	Canis familiaris	76.33	0.00e+00	743.00
IUUC-Cpo-021948	Cavia porcellus	72.65	0.00e+00	689.00
IUUC-Csa-023135	Chlorocebus sabaeus	99.16	0.00e+00	870.00
IUUC-Cho-024493	Choloepus hoffmanni	66.78	7.00e-98	350.00
IUUC-Dno-030061	Dasypus novemcinctus	72.40	0.00e+00	710.00
IUUC-Ete-033168	Echinops telfairi	70.37	2.00e-169	588.00
IUUC-Eca-033578	Equus caballus	81.37	0.00e+00	773.00
IUUC-Eeu-034749	Erinaceus europaeus	57.84	2.00e-131	462.00
IUUC-Fca-035468	Felis catus	75.10	0.00e+00	724.00
IUUC-Gac-041647	Gasterosteus aculeatus	34.73	7.00e-62	231.00
IUUC-Ggo-045190	Gorilla gorilla	96.00	0.00e+00	882.00
IUUC-Hsa-046583	Homo sapiens	95.79	0.00e+00	880.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	79.04	0.00e+00	738.00
IUUC-Kpa-049137	Komagataella pastoris	30.53	2.00e-09	56.60
IUUC-Laf-053455	Loxodonta africana	76.68	0.00e+00	686.00
IUUC-Mor-057034	Magnaporthe oryzae	41.07	3.00e-08	53.10
IUUC-Mmr-061369	Microcebus murinus	77.05	0.00e+00	663.00
IUUC-Mdo-062418	Monodelphis domestica	41.28	2.00e-91	329.00
IUUC-Mmu-063166	Mus musculus	71.58	0.00e+00	669.00
IUUC-Mpu-066889	Mustela putorius furo	76.28	0.00e+00	752.00
IUUC-Mlu-067647	Myotis lucifugus	80.09	0.00e+00	707.00
IUUC-Nle-069567	Nomascus leucogenys	96.21	0.00e+00	882.00
IUUC-Opr-071178	Ochotona princeps	64.00	2.00e-171	595.00
IUUC-Olu-087666	Ostreococcus lucimarinus	33.71	8.00e-11	62.00
IUUC-Oar-090413	Ovis aries	79.14	0.00e+00	716.00
IUUC-Ptr-091187	Pan troglodytes	95.79	0.00e+00	880.00
IUUC-Pan-092231	Papio anubis	99.57	0.00e+00	859.00
IUUC-Pab-098079	Pongo abelii	91.22	2.00e-175	607.00
IUUC-Pca-100639	Procavia capensis	74.37	5.00e-150	524.00
IUUC-Pva-102476	Pteropus vampyrus	79.16	0.00e+00	751.00
IUUC-Rno-105054	Rattus norvegicus	72.10	2.00e-177	615.00
IUUC-Sar-113204	Sorex araneus	74.84	0.00e+00	663.00
IUUC-Ssc-116291	Sus scrofa	78.42	0.00e+00	734.00
IUUC-Tru-117950	Takifugu rubripes	31.98	4.00e-47	182.00
IUUC-Tsy-118803	Tarsius syrichta	67.31	1.00e-161	562.00
IUUC-Tbe-127337	Tupaia belangeri	63.24	3.00e-113	401.00
IUUC-Ttr-128914	Tursiops truncatus	76.71	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence