iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090413

Ensembl Protein ID

ENSOARP00000000981.1

UniProt Accession

W5NS41; W5NS41_SHEEP

Genbank Protein ID

ENSOARP00000000981

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01032317

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000944.1	ENSOART00000001014.1	ENSOARP00000000981.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.20e-08	33.7	15	77
E3 activity/RING/RING	6.30e-08	33.2	19	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  C+I l++M +P+ +++G+++ +++I +  ++gg+ cPv+r+++  ++l Pn  + ++++
   Q: 15   EEVTCSICLDPMVEPMSIECGHSFCQECISEVGKEGGSVCPVCRRHFLLQNLRPNRQVANMVD 77
           6889***************************99**********************99888776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++ + p++  CgH f+++C+  +      + +   CP+Cr
   Q: 19   CSICLDPMVE-PMSIECGHSFCQECISEV-----GKEGGSVCPVCR 58
           ********99.***************999.....6778888****8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

ITPMASAVPL TMMWEEVTCS ICLDPMVEPM SIECGHSFCQ ECISEVGKEG GSVCPVCRRH 60
FLLQNLRPNR QVANMVDNLR KISQGAKEGP HGELCVVHRE KIHLFCEADG KALCWVCSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTCCCCAG CACTACCGAA GAGGAGCATC ACCCCAATGG CTTCAGCCGT ACCCTTGACA 60
ATGATGTGGG AGGAGGTCAC GTGCTCTATC TGCCTGGATC CCATGGTGGA GCCTATGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	78.06	0.00e+00	775.00
IUUC-Bta-013083	Bos taurus	90.20	0.00e+00	837.00
IUUC-Cel-018124	Caenorhabditis elegans	22.27	3.00e-11	62.40
IUUC-Cja-019002	Callithrix jacchus	78.06	0.00e+00	753.00
IUUC-Cfa-020415	Canis familiaris	73.33	0.00e+00	729.00
IUUC-Cpo-021948	Cavia porcellus	67.45	0.00e+00	658.00
IUUC-Csa-023135	Chlorocebus sabaeus	79.35	0.00e+00	696.00
IUUC-Cho-024493	Choloepus hoffmanni	62.24	6.00e-91	327.00
IUUC-Dno-030061	Dasypus novemcinctus	69.18	0.00e+00	688.00
IUUC-Ete-033168	Echinops telfairi	66.91	4.00e-165	574.00
IUUC-Eca-033578	Equus caballus	77.99	0.00e+00	744.00
IUUC-Eeu-034749	Erinaceus europaeus	54.87	2.00e-128	452.00
IUUC-Fca-035468	Felis catus	72.86	0.00e+00	706.00
IUUC-Ggo-045190	Gorilla gorilla	77.63	0.00e+00	712.00
IUUC-Hsa-046583	Homo sapiens	77.63	0.00e+00	715.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	75.16	0.00e+00	687.00
IUUC-Lch-049548	Latimeria chalumnae	36.80	1.00e-79	290.00
IUUC-Laf-053455	Loxodonta africana	74.22	0.00e+00	676.00
IUUC-Mcc-054609	Macaca mulatta	79.14	0.00e+00	693.00
IUUC-Mmr-061369	Microcebus murinus	72.57	2.00e-179	622.00
IUUC-Mmu-063166	Mus musculus	67.90	0.00e+00	633.00
IUUC-Mpu-066889	Mustela putorius furo	75.70	0.00e+00	752.00
IUUC-Mlu-067647	Myotis lucifugus	77.63	0.00e+00	688.00
IUUC-Nle-069567	Nomascus leucogenys	77.63	0.00e+00	712.00
IUUC-Opr-071178	Ochotona princeps	62.80	6.00e-167	580.00
IUUC-Ont-072675	Oreochromis niloticus	32.77	2.00e-66	246.00
IUUC-Ptr-091187	Pan troglodytes	77.63	0.00e+00	715.00
IUUC-Pan-092231	Papio anubis	79.14	0.00e+00	694.00
IUUC-Pab-098079	Pongo abelii	72.52	2.00e-141	495.00
IUUC-Pca-100639	Procavia capensis	69.92	3.00e-140	491.00
IUUC-Pva-102476	Pteropus vampyrus	75.70	0.00e+00	713.00
IUUC-Rno-105054	Rattus norvegicus	68.32	1.00e-166	579.00
IUUC-Sar-113204	Sorex araneus	72.49	0.00e+00	644.00
IUUC-Ssc-116291	Sus scrofa	81.51	0.00e+00	761.00
IUUC-Tsy-118803	Tarsius syrichta	75.38	3.00e-136	478.00
IUUC-Tbe-127337	Tupaia belangeri	59.52	3.00e-104	371.00
IUUC-Ttr-128914	Tursiops truncatus	81.29	0.00e+00	711.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence